00410001.cdx
     RDKit          2D

 12 13  0  0  0  0  0  0  0  0999 V2000
   -1.3404    0.2727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7671   -0.3006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0018    0.0210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0018   -0.8040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0960    0.8319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9070    1.0137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7010    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7149    1.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7289   -1.2095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4140   -0.7899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4420    0.0070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1691   -1.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  1  6  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  3  7  1  0
  4  9  1  0
  5  6  1  0
  7  8  2  0
  7 11  1  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
M  END
>  <From>  (1) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (1) 
1260302

>  <Ligand InChI>  (1) 
InChI=1S/C8H12N2O2/c11-6-1-2-8(7(12)10-6)3-4-9-5-8/h9H,1-5H2,(H,10,11,12)

>  <Ligand InChI Key>  (1) 
UKJXZGPIUGDZMZ-UHFFFAOYSA-N

>  <BindingDB MonomerID>  (1) 
594634

>  <BindingDB Ligand Name>  (1) 
2,7-Diazaspiro[4.5]decane-6,8-dione::US11584748, Example 1

>  <Target Name>  (1) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (1) 


>  <Ki (nM)>  (1) 


>  <IC50 (nM)>  (1) 


>  <Kd (nM)>  (1) 
 84.0

>  <EC50 (nM)>  (1) 


>  <kon (M-1-s-1)>  (1) 


>  <koff (s-1)>  (1) 


>  <pH>  (1) 


>  <Temp C>  (1) 


>  <Curation/DataSource>  (1) 
US Patent

>  <Article DOI>  (1) 


>  <BindingDB Entry DOI>  (1) 
10.7270/Q2TH8RMF

>  <PMID>  (1) 


>  <PubChem AID>  (1) 


>  <Patent Number>  (1) 
US11584748

>  <Authors>  (1) 
Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P

>  <Institution>  (1) 
C4 Therapeutics, Inc.

>  <Link to Ligand in BindingDB>  (1) 
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=594634

>  <Link to Ligand-Target Pair in BindingDB>  (1) 
http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=594634&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search

>  <Ligand HET ID in PDB>  (1) 


>  <PDB ID(s) for Ligand-Target Complex>  (1) 


>  <PubChem CID of Ligand>  (1) 
146198232

>  <PubChem SID of Ligand>  (1) 
479272587

>  <ChEBI ID of Ligand>  (1) 


>  <ChEMBL ID of Ligand>  (1) 


>  <DrugBank ID of Ligand>  (1) 


>  <IUPHAR_GRAC ID of Ligand>  (1) 


>  <KEGG ID of Ligand>  (1) 


>  <ZINC ID of Ligand>  (1) 


>  <Number of Protein Chains in Target (bigger than 1 implies a multichain complex)>  (1) 
1

>  <BindingDB Target Chain Sequence>  (1) 
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

>  <PDB ID(s) of Target Chain>  (1) 
4TZ4,5HXB,5V3O,6UML,6XK9,7LPS,7U8F,8CVP,8D7U,8D7V,8D7W,8D7X,8D7Y,8D7Z,8D80,8D81,8DEY,8OIZ,8OJH

>  <UniProt (SwissProt) Recommended Name of Target Chain>  (1) 
Protein cereblon

>  <UniProt (SwissProt) Entry Name of Target Chain>  (1) 
CRBN_HUMAN

>  <UniProt (SwissProt) Primary ID of Target Chain>  (1) 
Q96SW2

>  <UniProt (SwissProt) Secondary ID(s) of Target Chain>  (1) 
B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

>  <UniProt (SwissProt) Alternative ID(s) of Target Chain>  (1) 


>  <UniProt (TrEMBL) Submitted Name of Target Chain>  (1) 


>  <UniProt (TrEMBL) Entry Name of Target Chain>  (1) 


>  <UniProt (TrEMBL) Primary ID of Target Chain>  (1) 


>  <UniProt (TrEMBL) Secondary ID(s) of Target Chain>  (1) 


>  <UniProt (TrEMBL) Alternative ID(s) of Target Chain>  (1) 


$$$$
00414001.cdx
     RDKit          2D

 23 25  0  0  0  0  0  0  0  0999 V2000
   -1.1637   -1.0270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3668   -0.8134    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2039   -1.3842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9696   -1.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9696   -1.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8721   -0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0647   -0.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6656   -0.6742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6796    0.1471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6935   -2.2891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3756   -1.8714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4034   -1.0779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1273   -2.3169    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7471   -0.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3772   -1.8239    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5336    0.3533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1092    0.9653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9138    0.7231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1273   -0.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5440   -0.6571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8957    1.7622    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4790    2.3455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0988    1.9757    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  7  1  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  4  8  1  0
  5 10  1  0
  6  7  1  0
  8  9  2  0
  8 12  1  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
  1 14  1  0
  1 15  2  0
 14 16  2  0
 16 17  1  0
 17 18  2  0
 18 19  1  0
 19 20  2  0
 20 14  1  0
 17 21  1  0
 21 22  2  0
 21 23  1  0
M  CHG  2  21   1  23  -1
M  END
>  <From>  (2) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (2) 
1260306

>  <Ligand InChI>  (2) 
InChI=1S/C15H15N3O5/c19-12-4-5-15(14(21)16-12)6-7-17(9-15)13(20)10-2-1-3-11(8-10)18(22)23/h1-3,8H,4-7,9H2,(H,16,19,21)

>  <Ligand InChI Key>  (2) 
GWZKPDNVILXNJL-UHFFFAOYSA-N

>  <BindingDB MonomerID>  (2) 
594638

>  <BindingDB Ligand Name>  (2) 
2-(3-Nitrobenzoyl)-2,7-diazaspiro[4.5]decane-6,8-dione::US11584748, Example 5

>  <Target Name>  (2) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (2) 


>  <Ki (nM)>  (2) 


>  <IC50 (nM)>  (2) 


>  <Kd (nM)>  (2) 
 23.0

>  <EC50 (nM)>  (2) 


>  <kon (M-1-s-1)>  (2) 


>  <koff (s-1)>  (2) 


>  <pH>  (2) 


>  <Temp C>  (2) 


>  <Curation/DataSource>  (2) 
US Patent

>  <Article DOI>  (2) 


>  <BindingDB Entry DOI>  (2) 
10.7270/Q2TH8RMF

>  <PMID>  (2) 


>  <PubChem AID>  (2) 


>  <Patent Number>  (2) 
US11584748

>  <Authors>  (2) 
Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P

>  <Institution>  (2) 
C4 Therapeutics, Inc.

>  <Link to Ligand in BindingDB>  (2) 
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=594638

>  <Link to Ligand-Target Pair in BindingDB>  (2) 
http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=594638&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search

>  <Ligand HET ID in PDB>  (2) 


>  <PDB ID(s) for Ligand-Target Complex>  (2) 


>  <PubChem CID of Ligand>  (2) 
146198311

>  <PubChem SID of Ligand>  (2) 
479272591

>  <ChEBI ID of Ligand>  (2) 


>  <ChEMBL ID of Ligand>  (2) 


>  <DrugBank ID of Ligand>  (2) 


>  <IUPHAR_GRAC ID of Ligand>  (2) 


>  <KEGG ID of Ligand>  (2) 


>  <ZINC ID of Ligand>  (2) 


>  <Number of Protein Chains in Target (bigger than 1 implies a multichain complex)>  (2) 
1

>  <BindingDB Target Chain Sequence>  (2) 
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

>  <PDB ID(s) of Target Chain>  (2) 
4TZ4,5HXB,5V3O,6UML,6XK9,7LPS,7U8F,8CVP,8D7U,8D7V,8D7W,8D7X,8D7Y,8D7Z,8D80,8D81,8DEY,8OIZ,8OJH

>  <UniProt (SwissProt) Recommended Name of Target Chain>  (2) 
Protein cereblon

>  <UniProt (SwissProt) Entry Name of Target Chain>  (2) 
CRBN_HUMAN

>  <UniProt (SwissProt) Primary ID of Target Chain>  (2) 
Q96SW2

>  <UniProt (SwissProt) Secondary ID(s) of Target Chain>  (2) 
B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

>  <UniProt (SwissProt) Alternative ID(s) of Target Chain>  (2) 


>  <UniProt (TrEMBL) Submitted Name of Target Chain>  (2) 


>  <UniProt (TrEMBL) Entry Name of Target Chain>  (2) 


>  <UniProt (TrEMBL) Primary ID of Target Chain>  (2) 


>  <UniProt (TrEMBL) Secondary ID(s) of Target Chain>  (2) 


>  <UniProt (TrEMBL) Alternative ID(s) of Target Chain>  (2) 


$$$$
00415001.cdx
     RDKit          2D

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.6585    0.4234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1384    0.6369    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7091    0.0661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4748    0.3863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4748   -0.4350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3773    1.1937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5699    1.3747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1708    0.7761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1848    1.5974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1987   -0.8387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8808   -0.4211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9086    0.3724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6325   -0.8666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2419    1.0067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0388    0.7932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2523   -0.0037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6689   -0.5870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8720   -0.3735    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0492   -0.2172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6325    0.3662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2627   -1.0141    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6793   -1.5974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  7  1  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  4  8  1  0
  5 10  1  0
  6  7  1  0
  8  9  2  0
  8 12  1  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
  1 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18  1  1  0
 16 19  1  0
 19 20  2  0
 19 21  1  0
 21 22  1  0
M  END
>  <From>  (3) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (3) 
1260307

>  <Ligand InChI>  (3) 
InChI=1S/C15H17N3O4/c1-22-13(20)10-2-3-11(16-8-10)18-7-6-15(9-18)5-4-12(19)17-14(15)21/h2-3,8H,4-7,9H2,1H3,(H,17,19,21)

>  <Ligand InChI Key>  (3) 
RPHRAKWJWNEBDE-UHFFFAOYSA-N

>  <BindingDB MonomerID>  (3) 
594639

>  <BindingDB Ligand Name>  (3) 
Methyl 6-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2-yl)nicotinate::US11584748, Example 6

>  <Target Name>  (3) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (3) 


>  <Ki (nM)>  (3) 


>  <IC50 (nM)>  (3) 


>  <Kd (nM)>  (3) 
<1.000

>  <EC50 (nM)>  (3) 


>  <kon (M-1-s-1)>  (3) 


>  <koff (s-1)>  (3) 


>  <pH>  (3) 


>  <Temp C>  (3) 


>  <Curation/DataSource>  (3) 
US Patent

>  <Article DOI>  (3) 


>  <BindingDB Entry DOI>  (3) 
10.7270/Q2TH8RMF

>  <PMID>  (3) 


>  <PubChem AID>  (3) 


>  <Patent Number>  (3) 
US11584748

>  <Authors>  (3) 
Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P

>  <Institution>  (3) 
C4 Therapeutics, Inc.

>  <Link to Ligand in BindingDB>  (3) 
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=594639

>  <Link to Ligand-Target Pair in BindingDB>  (3) 
http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=594639&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search

>  <Ligand HET ID in PDB>  (3) 


>  <PDB ID(s) for Ligand-Target Complex>  (3) 


>  <PubChem CID of Ligand>  (3) 
146198277

>  <PubChem SID of Ligand>  (3) 
479272592

>  <ChEBI ID of Ligand>  (3) 


>  <ChEMBL ID of Ligand>  (3) 


>  <DrugBank ID of Ligand>  (3) 


>  <IUPHAR_GRAC ID of Ligand>  (3) 


>  <KEGG ID of Ligand>  (3) 


>  <ZINC ID of Ligand>  (3) 


>  <Number of Protein Chains in Target (bigger than 1 implies a multichain complex)>  (3) 
1

>  <BindingDB Target Chain Sequence>  (3) 
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

>  <PDB ID(s) of Target Chain>  (3) 
4TZ4,5HXB,5V3O,6UML,6XK9,7LPS,7U8F,8CVP,8D7U,8D7V,8D7W,8D7X,8D7Y,8D7Z,8D80,8D81,8DEY,8OIZ,8OJH

>  <UniProt (SwissProt) Recommended Name of Target Chain>  (3) 
Protein cereblon

>  <UniProt (SwissProt) Entry Name of Target Chain>  (3) 
CRBN_HUMAN

>  <UniProt (SwissProt) Primary ID of Target Chain>  (3) 
Q96SW2

>  <UniProt (SwissProt) Secondary ID(s) of Target Chain>  (3) 
B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

>  <UniProt (SwissProt) Alternative ID(s) of Target Chain>  (3) 


>  <UniProt (TrEMBL) Submitted Name of Target Chain>  (3) 


>  <UniProt (TrEMBL) Entry Name of Target Chain>  (3) 


>  <UniProt (TrEMBL) Primary ID of Target Chain>  (3) 


>  <UniProt (TrEMBL) Secondary ID(s) of Target Chain>  (3) 


>  <UniProt (TrEMBL) Alternative ID(s) of Target Chain>  (3) 


$$$$
00416001.cdx
     RDKit          2D

 21 24  0  0  0  0  0  0  0  0999 V2000
    0.0080    0.2817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5788   -0.2891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3444    0.0311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3444   -0.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2470    0.8385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4396    1.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0405    0.4209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0544    1.2422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0683   -1.1939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7504   -0.7763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7783    0.0172    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5022   -1.2218    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9084   -0.6589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1219    0.1380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9188    0.3515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5022   -0.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2886   -1.0287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4918   -1.2422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0845   -0.7020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7889    0.0682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4300    0.5873    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
 20  1  1  0
  1  2  1  0
  1  6  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  3  7  1  0
  4  9  1  0
  5  6  1  0
  7  8  2  0
  7 11  1  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 13  2  0
 13 19  1  0
 19 20  2  0
 20 21  1  0
 21 14  1  0
M  END
>  <From>  (4) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (4) 
1260308

>  <Ligand InChI>  (4) 
InChI=1S/C14H14N4O2S/c19-10-3-4-14(12(20)16-10)5-7-18(8-14)13-17-11-9(21-13)2-1-6-15-11/h1-2,6H,3-5,7-8H2,(H,16,19,20)

>  <Ligand InChI Key>  (4) 
JAMNHMJDAVFPED-UHFFFAOYSA-N

>  <BindingDB MonomerID>  (4) 
594640

>  <BindingDB Ligand Name>  (4) 
2-(Thiazolo[4,5-b]pyridin-2-yl)-2,7-diazaspiro[4.5]decane-6,8-dione::US11584748, Example 7

>  <Target Name>  (4) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (4) 


>  <Ki (nM)>  (4) 


>  <IC50 (nM)>  (4) 


>  <Kd (nM)>  (4) 
<1.000

>  <EC50 (nM)>  (4) 


>  <kon (M-1-s-1)>  (4) 


>  <koff (s-1)>  (4) 


>  <pH>  (4) 


>  <Temp C>  (4) 


>  <Curation/DataSource>  (4) 
US Patent

>  <Article DOI>  (4) 


>  <BindingDB Entry DOI>  (4) 
10.7270/Q2TH8RMF

>  <PMID>  (4) 


>  <PubChem AID>  (4) 


>  <Patent Number>  (4) 
US11584748

>  <Authors>  (4) 
Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P

>  <Institution>  (4) 
C4 Therapeutics, Inc.

>  <Link to Ligand in BindingDB>  (4) 
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=594640

>  <Link to Ligand-Target Pair in BindingDB>  (4) 
http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=594640&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search

>  <Ligand HET ID in PDB>  (4) 


>  <PDB ID(s) for Ligand-Target Complex>  (4) 


>  <PubChem CID of Ligand>  (4) 
146198297

>  <PubChem SID of Ligand>  (4) 
479272593

>  <ChEBI ID of Ligand>  (4) 


>  <ChEMBL ID of Ligand>  (4) 


>  <DrugBank ID of Ligand>  (4) 


>  <IUPHAR_GRAC ID of Ligand>  (4) 


>  <KEGG ID of Ligand>  (4) 


>  <ZINC ID of Ligand>  (4) 


>  <Number of Protein Chains in Target (bigger than 1 implies a multichain complex)>  (4) 
1

>  <BindingDB Target Chain Sequence>  (4) 
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

>  <PDB ID(s) of Target Chain>  (4) 
4TZ4,5HXB,5V3O,6UML,6XK9,7LPS,7U8F,8CVP,8D7U,8D7V,8D7W,8D7X,8D7Y,8D7Z,8D80,8D81,8DEY,8OIZ,8OJH

>  <UniProt (SwissProt) Recommended Name of Target Chain>  (4) 
Protein cereblon

>  <UniProt (SwissProt) Entry Name of Target Chain>  (4) 
CRBN_HUMAN

>  <UniProt (SwissProt) Primary ID of Target Chain>  (4) 
Q96SW2

>  <UniProt (SwissProt) Secondary ID(s) of Target Chain>  (4) 
B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

>  <UniProt (SwissProt) Alternative ID(s) of Target Chain>  (4) 


>  <UniProt (TrEMBL) Submitted Name of Target Chain>  (4) 


>  <UniProt (TrEMBL) Entry Name of Target Chain>  (4) 


>  <UniProt (TrEMBL) Primary ID of Target Chain>  (4) 


>  <UniProt (TrEMBL) Secondary ID(s) of Target Chain>  (4) 


>  <UniProt (TrEMBL) Alternative ID(s) of Target Chain>  (4) 


$$$$
00417001.cdx
     RDKit          2D

 21 23  0  0  0  0  0  0  0  0999 V2000
   -0.6585    0.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1384    0.3452    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7091   -0.2255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4748    0.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4748   -0.7267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3773    0.9021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5699    1.0830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1708    0.4844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1848    1.3058    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1987   -1.1304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8808   -0.7128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9086    0.0807    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6325   -1.1582    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2419    0.7151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0388    0.5015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2523   -0.2954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6689   -0.8787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8720   -0.6652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0492   -0.5089    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2627   -1.3058    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6325    0.0744    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  7  1  0
  3  4  1  0
  4  5  1  0
  4  6  1  0
  4  8  1  0
  5 10  1  0
  6  7  1  0
  8  9  2  0
  8 12  1  0
 10 11  1  0
 11 12  1  0
 11 13  2  0
  1 14  2  0
 14 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  2  0
 18  1  1  0
 16 19  1  0
 19 20  2  0
 19 21  1  0
M  CHG  2  19   1  21  -1
M  END
>  <From>  (5) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (5) 
1260309

>  <Ligand InChI>  (5) 
InChI=1S/C14H15N3O4/c18-12-5-6-14(13(19)15-12)7-8-16(9-14)10-1-3-11(4-2-10)17(20)21/h1-4H,5-9H2,(H,15,18,19)

>  <Ligand InChI Key>  (5) 
KVFAGCXJJHBNRS-UHFFFAOYSA-N

>  <BindingDB MonomerID>  (5) 
594641

>  <BindingDB Ligand Name>  (5) 
2-(4-Nitrophenyl)-2,7-diazaspiro[4.5]decane-6,8-dione::US11584748, Example 8

>  <Target Name>  (5) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (5) 


>  <Ki (nM)>  (5) 


>  <IC50 (nM)>  (5) 


>  <Kd (nM)>  (5) 
 14.0

>  <EC50 (nM)>  (5) 


>  <kon (M-1-s-1)>  (5) 


>  <koff (s-1)>  (5) 


>  <pH>  (5) 


>  <Temp C>  (5) 


>  <Curation/DataSource>  (5) 
US Patent

>  <Article DOI>  (5) 


>  <BindingDB Entry DOI>  (5) 
10.7270/Q2TH8RMF

>  <PMID>  (5) 


>  <PubChem AID>  (5) 


>  <Patent Number>  (5) 
US11584748

>  <Authors>  (5) 
Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P

>  <Institution>  (5) 
C4 Therapeutics, Inc.

>  <Link to Ligand in BindingDB>  (5) 
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=594641

>  <Link to Ligand-Target Pair in BindingDB>  (5) 
http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=594641&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search

>  <Ligand HET ID in PDB>  (5) 


>  <PDB ID(s) for Ligand-Target Complex>  (5) 


>  <PubChem CID of Ligand>  (5) 
146198268

>  <PubChem SID of Ligand>  (5) 
479272594

>  <ChEBI ID of Ligand>  (5) 


>  <ChEMBL ID of Ligand>  (5) 


>  <DrugBank ID of Ligand>  (5) 


>  <IUPHAR_GRAC ID of Ligand>  (5) 


>  <KEGG ID of Ligand>  (5) 


>  <ZINC ID of Ligand>  (5) 


>  <Number of Protein Chains in Target (bigger than 1 implies a multichain complex)>  (5) 
1

>  <BindingDB Target Chain Sequence>  (5) 
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

>  <PDB ID(s) of Target Chain>  (5) 
4TZ4,5HXB,5V3O,6UML,6XK9,7LPS,7U8F,8CVP,8D7U,8D7V,8D7W,8D7X,8D7Y,8D7Z,8D80,8D81,8DEY,8OIZ,8OJH

>  <UniProt (SwissProt) Recommended Name of Target Chain>  (5) 
Protein cereblon

>  <UniProt (SwissProt) Entry Name of Target Chain>  (5) 
CRBN_HUMAN

>  <UniProt (SwissProt) Primary ID of Target Chain>  (5) 
Q96SW2

>  <UniProt (SwissProt) Secondary ID(s) of Target Chain>  (5) 
B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

>  <UniProt (SwissProt) Alternative ID(s) of Target Chain>  (5) 


>  <UniProt (TrEMBL) Submitted Name of Target Chain>  (5) 


>  <UniProt (TrEMBL) Entry Name of Target Chain>  (5) 


>  <UniProt (TrEMBL) Primary ID of Target Chain>  (5) 


>  <UniProt (TrEMBL) Secondary ID(s) of Target Chain>  (5) 


>  <UniProt (TrEMBL) Alternative ID(s) of Target Chain>  (5) 


$$$$
00418001.cdx
     RDKit          2D

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.6981    0.2817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2689   -0.2891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0346    0.0311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0346   -0.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9371    0.8385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1297    1.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7306    0.4209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7445    1.2422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7584   -1.1939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4406   -0.7763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4684    0.0172    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1923   -1.2218    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2183   -0.6589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4318    0.1380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2287    0.3515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8121   -0.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5986   -1.0287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8017   -1.2422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3944   -0.7020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0987    0.0682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7399    0.5873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6089   -0.0182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1923   -0.6016    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8224    0.7787    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 20  1  1  0
  1  2  1  0
  1  6  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  3  7  1  0
  4  9  1  0
  5  6  1  0
  7  8  2  0
  7 11  1  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 13  2  0
 13 19  1  0
 19 20  1  0
 20 21  2  0
 21 14  1  0
 16 22  1  0
 22 23  2  0
 22 24  1  0
M  CHG  2  22   1  24  -1
M  END
>  <From>  (6) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (6) 
1260310

>  <Ligand InChI>  (6) 


>  <Ligand InChI Key>  (6) 


>  <BindingDB MonomerID>  (6) 
594642

>  <BindingDB Ligand Name>  (6) 
2-(5-Nitro-1H-benzo[d]imidazol-2-yl)-2,7-diazaspiro[4.5]decane-6,8-dione::US11584748, Example 9

>  <Target Name>  (6) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (6) 


>  <Ki (nM)>  (6) 


>  <IC50 (nM)>  (6) 


>  <Kd (nM)>  (6) 
 8.00

>  <EC50 (nM)>  (6) 


>  <kon (M-1-s-1)>  (6) 


>  <koff (s-1)>  (6) 


>  <pH>  (6) 


>  <Temp C>  (6) 


>  <Curation/DataSource>  (6) 
US Patent

>  <Article DOI>  (6) 


>  <BindingDB Entry DOI>  (6) 
10.7270/Q2TH8RMF

>  <PMID>  (6) 


>  <PubChem AID>  (6) 


>  <Patent Number>  (6) 
US11584748

>  <Authors>  (6) 
Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P

>  <Institution>  (6) 
C4 Therapeutics, Inc.

>  <Link to Ligand in BindingDB>  (6) 
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=594642

>  <Link to Ligand-Target Pair in BindingDB>  (6) 
http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=594642&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search

>  <Ligand HET ID in PDB>  (6) 


>  <PDB ID(s) for Ligand-Target Complex>  (6) 


>  <PubChem CID of Ligand>  (6) 
146198296

>  <PubChem SID of Ligand>  (6) 
479272595

>  <ChEBI ID of Ligand>  (6) 


>  <ChEMBL ID of Ligand>  (6) 


>  <DrugBank ID of Ligand>  (6) 


>  <IUPHAR_GRAC ID of Ligand>  (6) 


>  <KEGG ID of Ligand>  (6) 


>  <ZINC ID of Ligand>  (6) 


>  <Number of Protein Chains in Target (bigger than 1 implies a multichain complex)>  (6) 
1

>  <BindingDB Target Chain Sequence>  (6) 
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

>  <PDB ID(s) of Target Chain>  (6) 
4TZ4,5HXB,5V3O,6UML,6XK9,7LPS,7U8F,8CVP,8D7U,8D7V,8D7W,8D7X,8D7Y,8D7Z,8D80,8D81,8DEY,8OIZ,8OJH

>  <UniProt (SwissProt) Recommended Name of Target Chain>  (6) 
Protein cereblon

>  <UniProt (SwissProt) Entry Name of Target Chain>  (6) 
CRBN_HUMAN

>  <UniProt (SwissProt) Primary ID of Target Chain>  (6) 
Q96SW2

>  <UniProt (SwissProt) Secondary ID(s) of Target Chain>  (6) 
B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

>  <UniProt (SwissProt) Alternative ID(s) of Target Chain>  (6) 


>  <UniProt (TrEMBL) Submitted Name of Target Chain>  (6) 


>  <UniProt (TrEMBL) Entry Name of Target Chain>  (6) 


>  <UniProt (TrEMBL) Primary ID of Target Chain>  (6) 


>  <UniProt (TrEMBL) Secondary ID(s) of Target Chain>  (6) 


>  <UniProt (TrEMBL) Alternative ID(s) of Target Chain>  (6) 


$$$$
00419001.cdx
     RDKit          2D

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.6981    0.2817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2689   -0.2891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0346    0.0311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0346   -0.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9371    0.8385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1297    1.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7306    0.4209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7445    1.2422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7584   -1.1939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4406   -0.7763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4684    0.0172    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1923   -1.2218    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2183   -0.6589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4318    0.1380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2287    0.3515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8121   -0.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5986   -1.0287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8017   -1.2422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3944   -0.7020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0987    0.0682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7399    0.5873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6089   -0.0182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1923   -0.6016    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8224    0.7787    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 20  1  1  0
  1  2  1  0
  1  6  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  3  7  1  0
  4  9  1  0
  5  6  1  0
  7  8  2  0
  7 11  1  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 13  2  0
 13 19  1  0
 19 20  1  0
 20 21  2  0
 21 14  1  0
 16 22  1  0
 22 23  2  0
 22 24  1  0
M  CHG  2  22   1  24  -1
M  END
>  <From>  (7) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (7) 
1260311

>  <Ligand InChI>  (7) 


>  <Ligand InChI Key>  (7) 


>  <BindingDB MonomerID>  (7) 
594643

>  <BindingDB Ligand Name>  (7) 
(+)-2-(4-Nitrophenyl)-2,7-diazaspiro[4.5]decane-6,8-dione (Enantiomer 1)::US11584748, Example 10

>  <Target Name>  (7) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (7) 


>  <Ki (nM)>  (7) 


>  <IC50 (nM)>  (7) 


>  <Kd (nM)>  (7) 
 1.000

>  <EC50 (nM)>  (7) 


>  <kon (M-1-s-1)>  (7) 


>  <koff (s-1)>  (7) 


>  <pH>  (7) 


>  <Temp C>  (7) 


>  <Curation/DataSource>  (7) 
US Patent

>  <Article DOI>  (7) 


>  <BindingDB Entry DOI>  (7) 
10.7270/Q2TH8RMF

>  <PMID>  (7) 


>  <PubChem AID>  (7) 


>  <Patent Number>  (7) 
US11584748

>  <Authors>  (7) 
Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P

>  <Institution>  (7) 
C4 Therapeutics, Inc.

>  <Link to Ligand in BindingDB>  (7) 
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=594643

>  <Link to Ligand-Target Pair in BindingDB>  (7) 
http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=594643&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search

>  <Ligand HET ID in PDB>  (7) 


>  <PDB ID(s) for Ligand-Target Complex>  (7) 


>  <PubChem CID of Ligand>  (7) 
146198296

>  <PubChem SID of Ligand>  (7) 
479272596

>  <ChEBI ID of Ligand>  (7) 


>  <ChEMBL ID of Ligand>  (7) 


>  <DrugBank ID of Ligand>  (7) 


>  <IUPHAR_GRAC ID of Ligand>  (7) 


>  <KEGG ID of Ligand>  (7) 


>  <ZINC ID of Ligand>  (7) 


>  <Number of Protein Chains in Target (bigger than 1 implies a multichain complex)>  (7) 
1

>  <BindingDB Target Chain Sequence>  (7) 
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

>  <PDB ID(s) of Target Chain>  (7) 
4TZ4,5HXB,5V3O,6UML,6XK9,7LPS,7U8F,8CVP,8D7U,8D7V,8D7W,8D7X,8D7Y,8D7Z,8D80,8D81,8DEY,8OIZ,8OJH

>  <UniProt (SwissProt) Recommended Name of Target Chain>  (7) 
Protein cereblon

>  <UniProt (SwissProt) Entry Name of Target Chain>  (7) 
CRBN_HUMAN

>  <UniProt (SwissProt) Primary ID of Target Chain>  (7) 
Q96SW2

>  <UniProt (SwissProt) Secondary ID(s) of Target Chain>  (7) 
B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

>  <UniProt (SwissProt) Alternative ID(s) of Target Chain>  (7) 


>  <UniProt (TrEMBL) Submitted Name of Target Chain>  (7) 


>  <UniProt (TrEMBL) Entry Name of Target Chain>  (7) 


>  <UniProt (TrEMBL) Primary ID of Target Chain>  (7) 


>  <UniProt (TrEMBL) Secondary ID(s) of Target Chain>  (7) 


>  <UniProt (TrEMBL) Alternative ID(s) of Target Chain>  (7) 


$$$$
00420001.cdx
     RDKit          2D

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.6981    0.2817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2689   -0.2891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0346    0.0311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0346   -0.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9371    0.8385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1297    1.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7306    0.4209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7445    1.2422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7584   -1.1939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4406   -0.7763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4684    0.0172    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1923   -1.2218    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2183   -0.6589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4318    0.1380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2287    0.3515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8121   -0.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5986   -1.0287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8017   -1.2422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3944   -0.7020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0987    0.0682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7399    0.5873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6089   -0.0182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1923   -0.6016    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8224    0.7787    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 20  1  1  0
  1  2  1  0
  1  6  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  3  7  1  0
  4  9  1  0
  5  6  1  0
  7  8  2  0
  7 11  1  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 13  2  0
 13 19  1  0
 19 20  1  0
 20 21  2  0
 21 14  1  0
 16 22  1  0
 22 23  2  0
 22 24  1  0
M  CHG  2  22   1  24  -1
M  END
>  <From>  (8) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (8) 
1260312

>  <Ligand InChI>  (8) 


>  <Ligand InChI Key>  (8) 


>  <BindingDB MonomerID>  (8) 
594644

>  <BindingDB Ligand Name>  (8) 
(+2-(4-Nitrophenyl)-2,7-diazaspiro[4.5]decane-6,8-dione (Enantiomer 2)::US11584748, Example 11

>  <Target Name>  (8) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (8) 


>  <Ki (nM)>  (8) 


>  <IC50 (nM)>  (8) 


>  <Kd (nM)>  (8) 
 5.00

>  <EC50 (nM)>  (8) 


>  <kon (M-1-s-1)>  (8) 


>  <koff (s-1)>  (8) 


>  <pH>  (8) 


>  <Temp C>  (8) 


>  <Curation/DataSource>  (8) 
US Patent

>  <Article DOI>  (8) 


>  <BindingDB Entry DOI>  (8) 
10.7270/Q2TH8RMF

>  <PMID>  (8) 


>  <PubChem AID>  (8) 


>  <Patent Number>  (8) 
US11584748

>  <Authors>  (8) 
Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P

>  <Institution>  (8) 
C4 Therapeutics, Inc.

>  <Link to Ligand in BindingDB>  (8) 
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=594644

>  <Link to Ligand-Target Pair in BindingDB>  (8) 
http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=594644&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search

>  <Ligand HET ID in PDB>  (8) 


>  <PDB ID(s) for Ligand-Target Complex>  (8) 


>  <PubChem CID of Ligand>  (8) 
146198296

>  <PubChem SID of Ligand>  (8) 
479272597

>  <ChEBI ID of Ligand>  (8) 


>  <ChEMBL ID of Ligand>  (8) 


>  <DrugBank ID of Ligand>  (8) 


>  <IUPHAR_GRAC ID of Ligand>  (8) 


>  <KEGG ID of Ligand>  (8) 


>  <ZINC ID of Ligand>  (8) 


>  <Number of Protein Chains in Target (bigger than 1 implies a multichain complex)>  (8) 
1

>  <BindingDB Target Chain Sequence>  (8) 
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

>  <PDB ID(s) of Target Chain>  (8) 
4TZ4,5HXB,5V3O,6UML,6XK9,7LPS,7U8F,8CVP,8D7U,8D7V,8D7W,8D7X,8D7Y,8D7Z,8D80,8D81,8DEY,8OIZ,8OJH

>  <UniProt (SwissProt) Recommended Name of Target Chain>  (8) 
Protein cereblon

>  <UniProt (SwissProt) Entry Name of Target Chain>  (8) 
CRBN_HUMAN

>  <UniProt (SwissProt) Primary ID of Target Chain>  (8) 
Q96SW2

>  <UniProt (SwissProt) Secondary ID(s) of Target Chain>  (8) 
B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

>  <UniProt (SwissProt) Alternative ID(s) of Target Chain>  (8) 


>  <UniProt (TrEMBL) Submitted Name of Target Chain>  (8) 


>  <UniProt (TrEMBL) Entry Name of Target Chain>  (8) 


>  <UniProt (TrEMBL) Primary ID of Target Chain>  (8) 


>  <UniProt (TrEMBL) Secondary ID(s) of Target Chain>  (8) 


>  <UniProt (TrEMBL) Alternative ID(s) of Target Chain>  (8) 


$$$$
00421001.cdx
     RDKit          2D

 21 24  0  0  0  0  0  0  0  0999 V2000
    0.0080    0.2817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5788   -0.2891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3444    0.0311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3444   -0.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2470    0.8385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4396    1.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0405    0.4209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0544    1.2422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0683   -1.1939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7504   -0.7763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7783    0.0172    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5022   -1.2218    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9084   -0.6589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1219    0.1380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9188    0.3515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5022   -0.2318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2886   -1.0287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4918   -1.2422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0845   -0.7020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7889    0.0682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4300    0.5873    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
 20  1  1  0
  1  2  1  0
  1  6  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  3  7  1  0
  4  9  1  0
  5  6  1  0
  7  8  2  0
  7 11  1  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 13  2  0
 13 19  1  0
 19 20  2  0
 20 21  1  0
 21 14  1  0
M  END
>  <From>  (9) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (9) 
1260313

>  <Ligand InChI>  (9) 
InChI=1S/C15H15N3O2S/c19-12-5-6-15(13(20)17-12)7-8-18(9-15)14-16-10-3-1-2-4-11(10)21-14/h1-4H,5-9H2,(H,17,19,20)

>  <Ligand InChI Key>  (9) 
YVQKTFGXZGHQOQ-UHFFFAOYSA-N

>  <BindingDB MonomerID>  (9) 
594645

>  <BindingDB Ligand Name>  (9) 
2-(Benzo[d]thiazol-2-yl)-2,7-diazaspiro[4.5]decane-6,8-dione::US11584748, Example 12

>  <Target Name>  (9) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (9) 


>  <Ki (nM)>  (9) 


>  <IC50 (nM)>  (9) 


>  <Kd (nM)>  (9) 
 1.000

>  <EC50 (nM)>  (9) 


>  <kon (M-1-s-1)>  (9) 


>  <koff (s-1)>  (9) 


>  <pH>  (9) 


>  <Temp C>  (9) 


>  <Curation/DataSource>  (9) 
US Patent

>  <Article DOI>  (9) 


>  <BindingDB Entry DOI>  (9) 
10.7270/Q2TH8RMF

>  <PMID>  (9) 


>  <PubChem AID>  (9) 


>  <Patent Number>  (9) 
US11584748

>  <Authors>  (9) 
Nasveschuk, CG; Dey, F; Goergler, A; Kuhn, B; Norcross, R; Roever, S; Schmid, P

>  <Institution>  (9) 
C4 Therapeutics, Inc.

>  <Link to Ligand in BindingDB>  (9) 
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=594645

>  <Link to Ligand-Target Pair in BindingDB>  (9) 
http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=594645&enzyme=Protein+cereblon&column=ki&startPg=0&Increment=50&submit=Search

>  <Ligand HET ID in PDB>  (9) 


>  <PDB ID(s) for Ligand-Target Complex>  (9) 


>  <PubChem CID of Ligand>  (9) 
146198274

>  <PubChem SID of Ligand>  (9) 
479272598

>  <ChEBI ID of Ligand>  (9) 


>  <ChEMBL ID of Ligand>  (9) 


>  <DrugBank ID of Ligand>  (9) 


>  <IUPHAR_GRAC ID of Ligand>  (9) 


>  <KEGG ID of Ligand>  (9) 


>  <ZINC ID of Ligand>  (9) 


>  <Number of Protein Chains in Target (bigger than 1 implies a multichain complex)>  (9) 
1

>  <BindingDB Target Chain Sequence>  (9) 
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL

>  <PDB ID(s) of Target Chain>  (9) 
4TZ4,5HXB,5V3O,6UML,6XK9,7LPS,7U8F,8CVP,8D7U,8D7V,8D7W,8D7X,8D7Y,8D7Z,8D80,8D81,8DEY,8OIZ,8OJH

>  <UniProt (SwissProt) Recommended Name of Target Chain>  (9) 
Protein cereblon

>  <UniProt (SwissProt) Entry Name of Target Chain>  (9) 
CRBN_HUMAN

>  <UniProt (SwissProt) Primary ID of Target Chain>  (9) 
Q96SW2

>  <UniProt (SwissProt) Secondary ID(s) of Target Chain>  (9) 
B2R6H4 C9IZA9 C9JAH6 Q6AI62 Q6NVZ0 Q9UHW4

>  <UniProt (SwissProt) Alternative ID(s) of Target Chain>  (9) 


>  <UniProt (TrEMBL) Submitted Name of Target Chain>  (9) 


>  <UniProt (TrEMBL) Entry Name of Target Chain>  (9) 


>  <UniProt (TrEMBL) Primary ID of Target Chain>  (9) 


>  <UniProt (TrEMBL) Secondary ID(s) of Target Chain>  (9) 


>  <UniProt (TrEMBL) Alternative ID(s) of Target Chain>  (9) 


$$$$
00422001.cdx
     RDKit          2D

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.0080    1.3703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5788    0.7995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3444    1.1197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3444    0.2983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2470    1.9271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4396    2.1081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0405    1.5095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0544    2.3308    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0683   -0.1054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7504    0.3123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7783    1.1058    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5022   -0.1332    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9084    0.4297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1219    1.2266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9188    1.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5022    0.8568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2886    0.0599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4918   -0.1537    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0845    0.3865    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7889    1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4300    1.6759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2782   -0.9505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8616   -1.5339    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4813   -1.1641    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6481   -2.3308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 20  1  1  0
  1  2  1  0
  1  6  1  0
  2  3  1  0
  3  4  1  0
  3  5  1  0
  3  7  1  0
  4  9  1  0
  5  6  1  0
  7  8  2  0
  7 11  1  0
  9 10  1  0
 10 11  1  0
 10 12  2  0
 13 14  1  0
 14 15  2  0
 15 16  1  0
 16 17  2  0
 17 18  1  0
 18 13  2  0
 13 19  1  0
 19 20  1  0
 20 21  2  0
 21 14  1  0
 18 22  1  0
 22 23  1  0
 22 24  2  0
 23 25  1  0
M  END
>  <From>  (10) 
www.bindingDB.org

>  <BindingDB Reactant_set_id>  (10) 
1260314

>  <Ligand InChI>  (10) 


>  <Ligand InChI Key>  (10) 


>  <BindingDB MonomerID>  (10) 
594646

>  <BindingDB Ligand Name>  (10) 
Methyl 2-(6,8-dioxo-2,7-diazaspiro[4.5]decan-2-yl)-1H-benzo[d]imidazole-7-carboxylate::US11584748, Example 13

>  <Target Name>  (10) 
Protein cereblon

>  <Target Source Organism According to Curator or DataSource>  (10) 


>  <Ki (nM)>  (10) 


>  <IC50 (nM)>  (10) 


>  <Kd (nM)>  (10) 
 96.0

>  <EC50 (nM)>  (10) 


>  <kon (M-1-s-1)>  (10) 

