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Olaparib

E3L001072

Internal ID: BDB001072

Activity data available Local docking-ready structure

Dock with P09874

Structure

/e3_file/ligand_db/generated/BDB001072/BDB001072.sdf

Basic Properties

Compound ID

E3L001072

Internal ID

BDB001072

Molecular formula

C24H23FN4O3

Molecular weight

434.471000

Exact mass

434.175419

XLogP

2.3474

TPSA

86.3700

HBA / HBD

4 / 1

Rotatable bonds

Heavy atoms / rings

32 / 5

Activity summary

IC50 unknown 0.10000000 nM
100 activity record(s) imported

InChIKey

FDLYAMZZIXQODN-UHFFFAOYSA-N

SMILES

O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1

Aliases

BDBM27566 (preferred) Olaparib (source_name) BDBM27566 (source_id)

E3 Relation

E3 UniProt	Gene / protein	Relation type	Ligand role	Direct	Functional	Docking	Source	Evidence
P09874	PARP1;ADPRT;PPOL Poly [ADP-ribose] polymerase 1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM27566	medium ; target=Poly [ADP-ribose] polymerase 1

Sources and Literature

Source	Source ID	Source URL	Download URL	DOI / PMID
BindingDB	BDBM27566	Open	-	10.1021/jm8001263; 10.7270/Q22F7M7Z; 10.7270/Q2610Z5N; 10.1016/j.chembiol.2016.10.011; 10.7270/Q26T0PRW; 10.7270/Q2TM7F43; 10.1021/jm401550d; 10.1016/j.bmcl.2014.04.061; 10.1021/jm5002502; 10.7270/Q2BP07DW; 10.1016/j.bmcl.2014.07.001; 10.1021/jm5018237; 10.1021/acs.jmedchem.5b01498; 10.1021/acs.jmedchem.6b00990; 10.1016/j.ejmech.2017.03.013; 10.1016/j.bmc.2017.05.058; 10.1016/j.bmc.2017.05.052; 10.1016/j.ejmech.2017.06.053; 10.1016/j.ejmech.2017.07.050; 10.7270/Q2FB5754; 10.1021/acs.jmedchem.8b00576; 10.1021/jm301825t; 10.1016/j.bmcl.2013.06.055; 10.1016/j.bmcl.2013.12.048; 10.1016/j.bmc.2013.12.031; 10.1016/j.ejmech.2018.01.018; 10.1021/acs.jmedchem.5b01324; 10.1016/j.bmcl.2015.10.079; 10.1021/acs.jmedchem.8b01709; 10.1016/j.bmc.2019.07.050; 10.1016/j.ejmech.2019.111621; 10.1021/acs.jmedchem.9b00622; 10.1016/j.bmcl.2019.05.055; 10.1016/j.bmcl.2016.06.045; 10.1016/j.bmcl.2020.127036; 10.1016/j.bmc.2020.115819; 10.1016/j.bmcl.2020.127710; 10.1021/acs.jmedchem.0c01346; 10.1021/acs.jmedch PMID: 18800822; 27866910; 24521039; 24815508; 24922587; 37948954; 25086680; 25761096; 26652717; 28001384; 28340412; 28601509; 28622906; 28692916; 28763648; 33650861; 29856625; 23473053; 23850199; 24388690; 24398383; 29335205; 26469301; 26546219; 31042381; 31401008; 31442685; 31846325; 31153806; 27353531; 32088129; 33120078; 33246105; 33264017; 32924477; 30844273; 33740547; 34091044; 34404206; 34748333; 34813314; 33129590; 35643262; 35780655; 35785724; 35504210; 35531606; 35051747; 35091172; 34998039; 34570508; 36343904; 35430559; 35442700; 36512711; 35694689; 37616488; 37484567; 36155354; 38516606; 36921527; 36183505; 36989813; 37605459; 37752013; 37843892; 38554475; 38776379; 38134746; 38183777; 38375763; 38477575; 38678823; 38039793; 38911148; 38776806; 38838546; 39229909; 37478560; 37567056; 37832229; 26222319; 34038131
PubChem	CID23725625	Open	-

Structure Files

Kind	Format	Status	Docking use	File / link	Preparation note
canonical_2d	SMILES	raw	Docking-ready	O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1	keep_bindingdb_unique
generated_3d	SDF	prepared	Docking-ready	public/e3_file/ligand_db/generated/BDB001072/BDB001072.sdf	Generated from canonical SMILES
generated_3d	MOL2	prepared	Docking-ready	public/e3_file/ligand_db/generated/BDB001072/BDB001072.mol2	Generated from canonical SMILES
docking_ready	PDBQT	prepared	Docking-ready	public/e3_file/ligand_db/generated/BDB001072/BDB001072.pdbqt	Generated from canonical SMILES
image	PNG	prepared	Reference	public/e3_file/ligand_db/generated/BDB001072/BDB001072.png	Generated from canonical SMILES
image	SVG	prepared	Reference	public/e3_file/ligand_db/generated/BDB001072/BDB001072.svg	Generated from canonical SMILES

Activity

Target	Source	Assay	Result	Potency	Literature	Records
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	6 nM	Very high	DOI: 10.1016/j.bmcl.2014.04.061 PMID: 24815508	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	6 nM	Very high	DOI: 10.1021/acs.jmedchem.8b00576 PMID: 29856625	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	8.4 nM	Very high	DOI: 10.1016/j.bmc.2019.07.050 PMID: 31401008	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	3.4 nM	Very high	DOI: 10.1021/acs.jmedchem.0c00821 PMID: 32924477	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	86 nM	High	DOI: 10.7270/Q2610Z5N	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	10 nM	Very high	DOI: 10.1016/j.bmcl.2013.12.048 PMID: 24388690	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4.8 nM	Very high	DOI: 10.1021/acs.jmedchem.0c01346 PMID: 33264017	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	7 nM	Very high	DOI: 10.1021/jm5002502 PMID: 24922587	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.6 nM	Very high	DOI: 10.1021/acs.jmedchem.1c01535 PMID: 34813314	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	85 nM	High	DOI: 10.1016/j.bmcl.2014.07.001 PMID: 25086680	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1260 nM	Low	DOI: 10.7270/Q29P35PG PMID: 34998039	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	3600 nM	Low	DOI: 10.7270/Q2QC086X PMID: 38838546	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	6.7 nM	Very high	DOI: 10.1021/acs.jmedchem.3c00821 PMID: 37605459	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	8 nM	Very high	DOI: 10.7270/Q26T0PRW	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	12 nM	High	DOI: 10.1021/acs.jmedchem.5b01324 PMID: 26469301	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.4 nM	Very high	DOI: 10.1016/j.ejmech.2023.115300 PMID: 36989813	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.6 nM	Very high	DOI: 10.7270/Q2930Z6Q PMID: 35091172	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1 nM	Very high	DOI: 10.7270/Q2RB78MX PMID: 35504210	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5770 nM	Low	DOI: 10.7270/Q2DV1Q3C PMID: 35694689	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	11 nM	High	DOI: 10.7270/Q2FJ2MSP PMID: 35785724	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	139 nM	Moderate	DOI: 10.1016/j.bmc.2019.07.050 PMID: 31401008	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.9 nM	Very high	DOI: 10.1016/j.bmc.2020.115819 PMID: 33120078	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	20 nM	High	DOI: 10.1016/j.ejmech.2017.07.050 PMID: 28763648	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.1021/jm8001263 PMID: 18800822	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.5 nM	Very high	DOI: 10.7270/Q2ZK5N8H PMID: 38039793	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	8.1 nM	Very high	DOI: 10.1016/j.ejmech.2022.114790 PMID: 36183505	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4 nM	Very high	DOI: 10.7270/Q2K93CJV PMID: 35780655	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.8 nM	Very high	DOI: 10.1016/j.ejmech.2019.111621 PMID: 31442685	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.51 nM	Very high	DOI: 10.1021/acs.jmedchem.3c01194 PMID: 37752013	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.7270/Q2TM7GRK PMID: 38776379	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	69 nM	High	DOI: 10.1021/acs.jmedchem.6b00990 PMID: 28001384	2 source records
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	16 nM	High	DOI: 10.1021/jm401550d PMID: 24521039	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	36 nM	High	DOI: 10.1016/j.bmcl.2019.05.055 PMID: 31153806	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	<50 nM	High	DOI: 10.7270/Q2TM7F43	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4 nM	Very high	DOI: 10.1021/jm301825t PMID: 23473053	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.7270/Q2P55T62 PMID: 39229909	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.4 nM	Very high	DOI: 10.7270/Q2XK8KKJ PMID: 35051747	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.83 nM	Very high	DOI: 10.1021/acs.jmedchem.3c01152 PMID: 37843892	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.6 nM	Very high	DOI: 10.1021/acs.jmedchem.5b01324 PMID: 26469301	2 source records
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5.2 nM	Very high	DOI: 10.1016/j.bmcl.2020.127710 PMID: 33246105	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.73 nM	Very high	DOI: 10.7270/Q2V41095 PMID: 36343904	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4.2 nM	Very high	DOI: 10.7270/Q2TM7GRK PMID: 38776379	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4.2 nM	Very high	DOI: 10.1016/j.chembiol.2016.10.011 PMID: 27866910	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.1021/jm5018237 PMID: 25761096	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4.4 nM	Very high	DOI: 10.1016/j.ejmech.2023.115300 PMID: 36989813	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	2.8 nM	Very high	DOI: 10.7270/Q21N85RF PMID: 38678823	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.7270/Q2FB5754 PMID: 33650861	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.4 nM	Very high	DOI: 10.7270/Q2W66RDH PMID: 38375763	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.1016/j.ejmech.2022.114742 PMID: 36155354	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.5 nM	Very high	DOI: 10.7270/Q2Z60T8W PMID: 36512711	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	8.7 nM	Very high	DOI: 10.7270/Q2KW5MNQ PMID: 38134746	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	19 nM	High	DOI: 10.1021/acs.jmedchem.6b00990 PMID: 28001384	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	20 nM	High	DOI: 10.7270/Q2XD168K PMID: 38554475	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	43 nM	High	DOI: 10.7270/Q2610Z5N	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	6 nM	Very high	DOI: 10.1016/j.bmcl.2013.06.055 PMID: 23850199	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4.1 nM	Very high	DOI: 10.7270/Q2445S6B PMID: 37567056	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.6 nM	Very high	DOI: 10.7270/Q2RB78MX PMID: 35504210	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.7270/Q29G5SFG PMID: 38183777	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4.3 nM	Very high	DOI: 10.7270/Q2Z3248B PMID: 38477575	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	8 nM	Very high	DOI: 10.7270/Q2X06C52 PMID: 35442700	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.2 nM	Very high	DOI: 10.1021/acs.jmedchem.8b01709 PMID: 31042381	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	2.5 nM	Very high	DOI: 10.7270/Q2WW7NNP PMID: 33129590	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.9 nM	Very high	DOI: 10.7270/Q20006RZ PMID: 38911148	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.9 nM	Very high	DOI: 10.1021/acs.jmedchem.5b01498 PMID: 26652717	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5.1 nM	Very high	DOI: 10.1021/acs.jmedchem.1c00735 PMID: 34404206	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.63 nM	Very high	DOI: 10.7270/Q22F7SD8 PMID: 35643262	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	34 nM	High	DOI: 10.7270/Q2WW7NNP PMID: 33129590	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4.5 nM	Very high	DOI: 10.1016/j.bmc.2013.12.031 PMID: 24398383	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.9 nM	Very high	DOI: 10.7270/Q2610Z5N	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	6 nM	Very high	DOI: 10.1039/d3md00751k PMID: 38516606	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.1021/acs.jmedchem.3c01152 PMID: 37843892	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	139 nM	Moderate	DOI: 10.7270/Q2Z60T8W PMID: 36512711	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.4 nM	Very high	DOI: 10.1021/acs.jmedchem.6b00990 PMID: 28001384	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.7270/Q2BP07DW PMID: 37948954	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.3 nM	Very high	DOI: 10.1016/j.ejmech.2021.113357 PMID: 33740547	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	<50 nM	High	DOI: 10.7270/Q2610Z5N	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.1021/acs.jmedchem.9b00622 PMID: 31846325	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.1 nM	Very high	DOI: 10.7270/Q2MK6JJ4 PMID: 38776806	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	2.1 nM	Very high	DOI: 10.1021/acs.jmedchem.1c01522 PMID: 34748333	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1 nM	Very high	DOI: 10.1016/j.bmcl.2015.10.079 PMID: 26546219	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	2.1 nM	Very high	DOI: 10.1021/acs.jmedchem.3c01152 PMID: 37843892	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4 nM	Very high	DOI: 10.7270/Q2T72NJ8 PMID: 35430559	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	7090 nM	Low	DOI: 10.7270/Q27D3059 PMID: 35531606	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	4.2 nM	Very high	DOI: 10.1016/j.bmcl.2020.127036 PMID: 32088129	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	0.411 nM	Very high	DOI: 10.1039/d3md00117b PMID: 37484567	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	7.5 nM	Very high	DOI: 10.7270/Q2HX1JCH PMID: 37832229	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	1.1 nM	Very high	DOI: 10.1016/j.bmcl.2021.128169 PMID: 34091044	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	3.6 nM	Very high	DOI: 10.1016/j.bmc.2019.07.050 PMID: 31401008	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	11 nM	High	DOI: 10.1016/j.ejmech.2018.01.018 PMID: 29335205	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	11 nM	High	DOI: 10.7270/Q2V41095 PMID: 36343904	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	5 nM	Very high	DOI: 10.7270/Q2Z3248B PMID: 38477575	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	12 nM	High	DOI: 10.7270/Q22F7M7Z	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	3.6 nM	Very high	DOI: 10.1016/j.bmc.2017.05.058 PMID: 28601509	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	8 nM	Very high	DOI: 10.7270/Q2Q2450D PMID: 37478560	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	7 nM	Very high	DOI: 10.7270/Q2Z03D7J PMID: 34570508	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	20 nM	High	DOI: 10.1021/acs.jmedchem.3c00640 PMID: 37616488	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	8.1 nM	Very high	DOI: 10.1016/j.bmc.2017.05.052 PMID: 28622906	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM27566	IC50	19 nM	High	DOI: 10.1016/j.ejmech.2017.06.053 PMID: 28692916	1