| E3 UniProt | Gene / protein | Relation type | Ligand role | Direct | Functional | Docking | Source | Evidence |
|---|---|---|---|---|---|---|---|---|
| Q6GQQ9 | OTUD7B;ZA20D1 OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne) |
reported_binder | bindingdb_reported | Yes | No | low | BindingDB:BDBM436098 | medium ; target=OTU domain-containing protein 7B |
| Kind | Format | Status | Docking use | File / link | Preparation note |
|---|---|---|---|---|---|
| canonical_2d | SMILES | raw | Docking-ready | CNC(=O)c1cccc(-c2ccc3nc(NC(=O)C4(F)CCN(C#N)C4)sc3c2)c1 | keep_bindingdb_unique |
| generated_3d | SDF | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB018199/BDB018199.sdf | Generated from canonical SMILES |
| generated_3d | MOL2 | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB018199/BDB018199.mol2 | Generated from canonical SMILES |
| docking_ready | PDBQT | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB018199/BDB018199.pdbqt | Generated from canonical SMILES |
| image | PNG | prepared | Reference | public/e3_file/ligand_db/generated/BDB018199/BDB018199.png | Generated from canonical SMILES |
| image | SVG | prepared | Reference | public/e3_file/ligand_db/generated/BDB018199/BDB018199.svg | Generated from canonical SMILES |
| Target | Source | Assay | Result | Potency | Literature | Records |
|---|---|---|---|---|---|---|
|
OTU domain-containing protein 7B Q6GQQ9 E3 ligase component |
BindingDB:BDBM436098 | IC50 | 5500 nM | Low | DOI: 10.7270/Q2280BNN | 1 |