| E3 UniProt | Gene / protein | Relation type | Ligand role | Direct | Functional | Docking | Source | Evidence |
|---|---|---|---|---|---|---|---|---|
| P09936 | UCHL1 Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
reported_binder | bindingdb_reported | Yes | No | low | BindingDB:BDBM445140 | medium ; target=Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| Kind | Format | Status | Docking use | File / link | Preparation note |
|---|---|---|---|---|---|
| canonical_2d | SMILES | raw | Docking-ready | COc1cccc(-c2csc(N(C)C(=O)[C@@H]3CCCN3C#N)n2)n1 | keep_bindingdb_unique |
| generated_3d | SDF | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB018869/BDB018869.sdf | Generated from canonical SMILES |
| generated_3d | MOL2 | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB018869/BDB018869.mol2 | Generated from canonical SMILES |
| docking_ready | PDBQT | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB018869/BDB018869.pdbqt | Generated from canonical SMILES |
| image | PNG | prepared | Reference | public/e3_file/ligand_db/generated/BDB018869/BDB018869.png | Generated from canonical SMILES |
| image | SVG | prepared | Reference | public/e3_file/ligand_db/generated/BDB018869/BDB018869.svg | Generated from canonical SMILES |
| Target | Source | Assay | Result | Potency | Literature | Records |
|---|---|---|---|---|---|---|
|
Ubiquitin carboxyl-terminal hydrolase isozyme L1 P09936 E3 ligase component |
BindingDB:BDBM445140 | IC50 | 550 nM | Moderate | DOI: 10.7270/Q2CN774X | 1 |
|
Ubiquitin carboxyl-terminal hydrolase isozyme L1 P09936 E3 ligase component |
BindingDB:BDBM445140 | IC50 | 550 nM | Moderate | DOI: 10.7270/Q22N559S | 1 |