| E3 UniProt | Gene / protein | Relation type | Ligand role | Direct | Functional | Docking | Source | Evidence |
|---|---|---|---|---|---|---|---|---|
| P40337 | VHL von Hippel-Lindau disease tumor suppressor |
reported_binder | bindingdb_reported | Yes | No | low | BindingDB:BDBM581972 | medium ; target=Cullin-2 |
| P62877 | RBX1;RNF75;ROC1 E3 ubiquitin-protein ligase RBX1 |
reported_binder | bindingdb_reported | Yes | No | low | BindingDB:BDBM581972 | medium ; target=Cullin-2 |
| Q13617 | CUL2 Cullin-2 |
reported_binder | bindingdb_reported | Yes | No | low | BindingDB:BDBM581972 | medium ; target=Cullin-2 |
| Kind | Format | Status | Docking use | File / link | Preparation note |
|---|---|---|---|---|---|
| canonical_2d | SMILES | raw | Docking-ready | Cc1cc([C@@H](C)C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)on1 | keep_bindingdb_unique |
| generated_3d | SDF | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB028874/BDB028874.sdf | Generated from canonical SMILES |
| generated_3d | MOL2 | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB028874/BDB028874.mol2 | Generated from canonical SMILES |
| docking_ready | PDBQT | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB028874/BDB028874.pdbqt | Generated from canonical SMILES |
| image | PNG | prepared | Reference | public/e3_file/ligand_db/generated/BDB028874/BDB028874.png | Generated from canonical SMILES |
| image | SVG | prepared | Reference | public/e3_file/ligand_db/generated/BDB028874/BDB028874.svg | Generated from canonical SMILES |
| Target | Source | Assay | Result | Potency | Literature | Records |
|---|---|---|---|---|---|---|
|
Cullin-2 P62877 E3 ligase component |
BindingDB:BDBM581972 | IC50 | 2380 nM | Low | DOI: 10.7270/Q20K2DC4 | 1 |
|
Cullin-2 P40337 E3 ligase component |
BindingDB:BDBM581972 | IC50 | 2380 nM | Low | DOI: 10.7270/Q20K2DC4 | 1 |
|
Cullin-2 Q13617 E3 ligase component |
BindingDB:BDBM581972 | IC50 | 2380 nM | Low | DOI: 10.7270/Q20K2DC4 | 1 |