| E3 UniProt | Gene / protein | Relation type | Ligand role | Direct | Functional | Docking | Source | Evidence |
|---|---|---|---|---|---|---|---|---|
| P40337 | VHL von Hippel-Lindau disease tumor suppressor |
reported_binder | bindingdb_reported | Yes | No | low | BindingDB:BDBM622006 | medium ; target=von Hippel-Lindau disease tumor suppressor |
| Kind | Format | Status | Docking use | File / link | Preparation note |
|---|---|---|---|---|---|
| canonical_2d | SMILES | raw | Docking-ready | COc1ccc(-c2[nH]c([C@@H]3C[C@@H](O)CN3C(=O)C(c3cc(OC)no3)C(C)C)nc2C(F)(F)F)cc1 | keep_bindingdb_unique |
| generated_3d | SDF | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB031164/BDB031164.sdf | Generated from canonical SMILES |
| generated_3d | MOL2 | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB031164/BDB031164.mol2 | Generated from canonical SMILES |
| docking_ready | PDBQT | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB031164/BDB031164.pdbqt | Generated from canonical SMILES |
| image | PNG | prepared | Reference | public/e3_file/ligand_db/generated/BDB031164/BDB031164.png | Generated from canonical SMILES |
| image | SVG | prepared | Reference | public/e3_file/ligand_db/generated/BDB031164/BDB031164.svg | Generated from canonical SMILES |
| Target | Source | Assay | Result | Potency | Literature | Records |
|---|---|---|---|---|---|---|
|
von Hippel-Lindau disease tumor suppressor P40337 E3 ligase component |
BindingDB:BDBM622006 | Kd | 5500 nM | Low | DOI: 10.7270/Q25H7MF8 | 1 |