| E3 UniProt | Gene / protein | Relation type | Ligand role | Direct | Functional | Docking | Source | Evidence |
|---|---|---|---|---|---|---|---|---|
| O95835 | LATS1;WARTS Serine/threonine-protein kinase LATS1 |
reported_binder | bindingdb_reported | Yes | No | low | BindingDB:BDBM701005 | medium ; target=Serine/threonine-protein kinase LATS1 |
| Source | Source ID | Source URL | Download URL | DOI / PMID |
|---|---|---|---|---|
| BindingDB | BDBM701005 | Open | - | 10.7270/Q2H136HZ |
| Kind | Format | Status | Docking use | File / link | Preparation note |
|---|---|---|---|---|---|
| canonical_2d | SMILES | raw | Docking-ready | CCc1ccccc1N1CCS/C1=N/C(=O)c1c[nH]c2ncccc12 | keep_bindingdb_unique |
| generated_3d | SDF | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB034843/BDB034843.sdf | Generated from canonical SMILES |
| generated_3d | MOL2 | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB034843/BDB034843.mol2 | Generated from canonical SMILES |
| docking_ready | PDBQT | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB034843/BDB034843.pdbqt | Generated from canonical SMILES |
| image | PNG | prepared | Reference | public/e3_file/ligand_db/generated/BDB034843/BDB034843.png | Generated from canonical SMILES |
| image | SVG | prepared | Reference | public/e3_file/ligand_db/generated/BDB034843/BDB034843.svg | Generated from canonical SMILES |
| Target | Source | Assay | Result | Potency | Literature | Records |
|---|---|---|---|---|---|---|
|
Serine/threonine-protein kinase LATS1 O95835 E3 ligase component |
BindingDB:BDBM701005 | IC50 | 4.2 nM | Very high | DOI: 10.7270/Q2H136HZ | 1 |