| E3 UniProt | Gene / protein | Relation type | Ligand role | Direct | Functional | Docking | Source | Evidence |
|---|---|---|---|---|---|---|---|---|
| Q8TAF3 | WDR48;KIAA1449;UAF1 WD repeat-containing protein 48 |
reported_binder | bindingdb_reported | Yes | No | low | BindingDB:BDBM771969 | medium ; target=Ubiquitin carboxyl-terminal hydrolase 1 |
| Kind | Format | Status | Docking use | File / link | Preparation note |
|---|---|---|---|---|---|
| canonical_2d | SMILES | raw | Docking-ready | [2H]C([2H])([2H])N(Cc1ccc(-c2nc(C(F)(F)F)cn2C(C)C)cc1)c1nc(-c2c(OC)ncnc2C2CC2)ncc1F | keep_bindingdb_unique |
| generated_3d | SDF | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB041168/BDB041168.sdf | Generated from canonical SMILES |
| generated_3d | MOL2 | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB041168/BDB041168.mol2 | Generated from canonical SMILES |
| docking_ready | PDBQT | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB041168/BDB041168.pdbqt | Generated from canonical SMILES |
| image | PNG | prepared | Reference | public/e3_file/ligand_db/generated/BDB041168/BDB041168.png | Generated from canonical SMILES |
| image | SVG | prepared | Reference | public/e3_file/ligand_db/generated/BDB041168/BDB041168.svg | Generated from canonical SMILES |
| Target | Source | Assay | Result | Potency | Literature | Records |
|---|---|---|---|---|---|---|
|
Ubiquitin carboxyl-terminal hydrolase 1 Q8TAF3 E3 ligase component |
BindingDB:BDBM771969 | IC50 | 9 nM | Very high | DOI: 10.7270/Q2KS6X99 | 1 |