| E3 UniProt | Gene / protein | Relation type | Ligand role | Direct | Functional | Docking | Source | Evidence |
|---|---|---|---|---|---|---|---|---|
| Q8TAF3 | WDR48;KIAA1449;UAF1 WD repeat-containing protein 48 |
reported_binder | bindingdb_reported | Yes | No | low | BindingDB:BDBM771990 | medium ; target=Ubiquitin carboxyl-terminal hydrolase 1 |
| Kind | Format | Status | Docking use | File / link | Preparation note |
|---|---|---|---|---|---|
| canonical_2d | SMILES | raw | Docking-ready | Cc1ncn(C(C)C)c1-c1nc(NCC23CCC(c4ccc(C(F)(F)F)cn4)(CC2)CC3)c2occc2n1 | keep_bindingdb_unique |
| generated_3d | SDF | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB041189/BDB041189.sdf | Generated from canonical SMILES |
| generated_3d | MOL2 | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB041189/BDB041189.mol2 | Generated from canonical SMILES |
| docking_ready | PDBQT | prepared | Docking-ready | public/e3_file/ligand_db/generated/BDB041189/BDB041189.pdbqt | Generated from canonical SMILES |
| image | PNG | prepared | Reference | public/e3_file/ligand_db/generated/BDB041189/BDB041189.png | Generated from canonical SMILES |
| image | SVG | prepared | Reference | public/e3_file/ligand_db/generated/BDB041189/BDB041189.svg | Generated from canonical SMILES |
| Target | Source | Assay | Result | Potency | Literature | Records |
|---|---|---|---|---|---|---|
|
Ubiquitin carboxyl-terminal hydrolase 1 Q8TAF3 E3 ligase component |
BindingDB:BDBM771990 | IC50 | 431 nM | Moderate | DOI: 10.7270/Q2KS6X99 | 1 |