E3Docker 2.0

NVP-BHG712 isomer

E3L065426

Internal ID: BDB065426

Activity data available Local docking-ready structure

Dock with O14965 Dock with O15143 Dock with O43684 Dock with O75083 Dock with O75592 Dock with O94822 Dock with O94874 Dock with O95835 Dock with P09874 Dock with P09936 Dock with P31146 Dock with P35606 Dock with P35637 Dock with P49792 Dock with P51617 Dock with P51948 Dock with P53621 Dock with P55735 Dock with P61962 Dock with P61964 Dock with P62873 Dock with P63151 Dock with P78406 Dock with Q01518 Dock with Q09028 Dock with Q12873 Dock with Q12933 Dock with Q13042 Dock with Q13064 Dock with Q13233 Dock with Q13263 Dock with Q13309 Dock with Q13347 Dock with Q13409 Dock with Q13501 Dock with Q13616 Dock with Q13617 Dock with Q13618 Dock with Q14139 Dock with Q14258 Dock with Q14839 Dock with Q15257 Dock with Q15369 Dock with Q15370 Dock with Q15386 Dock with Q15843 Dock with Q16531 Dock with Q16576 Dock with Q5T4S7 Dock with Q63HN8 Dock with Q6UXN9 Dock with Q6ZNB6 Dock with Q7Z5L9 Dock with Q7Z6Z7 Dock with Q86TM6 Dock with Q8IWR1 Dock with Q8N5U6 Dock with Q8NI36 Dock with Q8TEQ6 Dock with Q8WUA4 Dock with Q92844 Dock with Q92900 Dock with Q96J02 Dock with Q9BVC4 Dock with Q9BZK7 Dock with Q9C037 Dock with Q9C0J8 Dock with Q9H0A0 Dock with Q9NRL2

Structure

/e3_file/ligand_db/generated/BDB065426/BDB065426.sdf

Basic Properties

Compound ID

E3L065426

Internal ID

BDB065426

Molecular formula

C26H20F3N7O

Molecular weight

503.488000

Exact mass

503.168143

XLogP

5.7484

TPSA

97.6200

HBA / HBD

6 / 2

Rotatable bonds

Heavy atoms / rings

37 / 5

Activity summary

Kd unknown 2.40000000 nM
69 activity record(s) imported

InChIKey

MWKSRKSEWLRPBL-UHFFFAOYSA-N

SMILES

Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12

Aliases

BDBM50652793 (preferred) NVP-BHG712 isomer (source_name) BDBM50652793 (source_id)

E3 Relation

E3 UniProt	Gene / protein	Relation type	Ligand role	Direct	Functional	Docking	Source	Evidence
O14965	AURKA;AIK;AIRK1;ARK1;AURA;AYK1;BTAK;IAK1;STK15;STK6 Aurora kinase A	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Aurora kinase A
O15143	ARPC1B;ARC41 Actin-related protein 2/3 complex subunit 1B	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Actin-related protein 2/3 complex subunit 1B
O43684	BUB3 Mitotic checkpoint protein BUB3	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Mitotic checkpoint protein BUB3
O75083	WDR1 WD repeat-containing protein 1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=WD repeat-containing protein 1
O75592	MYCBP2;KIAA0916;PAM E3 ubiquitin-protein ligase MYCBP2	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase MYCBP2
O94822	LTN1;C21orf10;C21orf98;KIAA0714;RNF160;ZNF294;HSPC087 E3 ubiquitin-protein ligase listerin	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase listerin
O94874	UFL1;KIAA0776;MAXER;NLBP;RCAD E3 UFM1-protein ligase 1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 UFM1-protein ligase 1
O95835	LATS1;WARTS Serine/threonine-protein kinase LATS1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Serine/threonine-protein kinase LATS1
P09874	PARP1;ADPRT;PPOL Poly [ADP-ribose] polymerase 1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Poly [ADP-ribose] polymerase 1
P09936	UCHL1 Ubiquitin carboxyl-terminal hydrolase isozyme L1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Ubiquitin carboxyl-terminal hydrolase isozyme L1
P31146	CORO1A;CORO1 Coronin-1A	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Coronin-1A
P35606	COPB2 Coatomer subunit beta'	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Coatomer subunit beta'
P35637	FUS;TLS RNA-binding protein FUS	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=RNA-binding protein FUS
P49792	RANBP2;NUP358 E3 SUMO-protein ligase RanBP2	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 SUMO-protein ligase RanBP2
P51617	IRAK1;IRAK Interleukin-1 receptor-associated kinase 1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Interleukin-1 receptor-associated kinase 1
P51948	MNAT1;CAP35;MAT1;RNF66 CDK-activating kinase assembly factor MAT1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=CDK-activating kinase assembly factor MAT1
P53621	COPA Coatomer subunit alpha	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Coatomer subunit alpha
P55735	SEC13;D3S1231E;SEC13A;SEC13L1;SEC13R Protein SEC13 homolog	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Protein SEC13 homolog
P61962	DCAF7;HAN11;WDR68 DDB1- and CUL4-associated factor 7	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=DDB1- and CUL4-associated factor 7
P61964	WDR5;BIG3 WD repeat-containing protein 5	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=WD repeat-containing protein 5
P62873	GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
P63151	PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
P78406	RAE1;MRNP41 mRNA export factor RAE1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=mRNA export factor RAE1
Q01518	CAP1;CAP Adenylyl cyclase-associated protein 1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Adenylyl cyclase-associated protein 1
Q09028	RBBP4;RBAP48 Histone-binding protein RBBP4	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Histone-binding protein RBBP4
Q12873	CHD3 Chromodomain-helicase-DNA-binding protein 3	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Chromodomain-helicase-DNA-binding protein 3
Q12933	TRAF2;TRAP3 TNF receptor-associated factor 2	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=TNF receptor-associated factor 2
Q13042	CDC16;ANAPC6 Cell division cycle protein 16 homolog	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Cell division cycle protein 16 homolog
Q13064	MKRN3;D15S9;RNF63;ZNF127 Probable E3 ubiquitin-protein ligase makorin-3	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase makorin-3
Q13233	MAP3K1;MAPKKK1;MEKK;MEKK1 Mitogen-activated protein kinase kinase kinase 1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Mitogen-activated protein kinase kinase kinase 1
Q13263	TRIM28;KAP1;RNF96;TIF1B Transcription intermediary factor 1-beta	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Transcription intermediary factor 1-beta
Q13309	SKP2;FBXL1 S-phase kinase-associated protein 2	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=S-phase kinase-associated protein 2
Q13347	EIF3I;EIF3S2;TRIP1 Eukaryotic translation initiation factor 3 subunit I	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Eukaryotic translation initiation factor 3 subunit I
Q13409	DYNC1I2;DNCI2;DNCIC2 Cytoplasmic dynein 1 intermediate chain 2	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Cytoplasmic dynein 1 intermediate chain 2
Q13501	SQSTM1;ORCA;OSIL Sequestosome-1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Sequestosome-1
Q13616	CUL1 Cullin-1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Cullin-1
Q13617	CUL2 Cullin-2	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Cullin-2
Q13618	CUL3;KIAA0617 Cullin-3	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Cullin-3
Q14139	UBE4A;KIAA0126 Ubiquitin conjugation factor E4 A	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Ubiquitin conjugation factor E4 A
Q14258	TRIM25;EFP;RNF147;ZNF147 E3 ubiquitin/ISG15 ligase TRIM25	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin/ISG15 ligase TRIM25
Q14839	CHD4 Chromodomain-helicase-DNA-binding protein 4	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Chromodomain-helicase-DNA-binding protein 4
Q15257	PTPA;PPP2R4 Serine/threonine-protein phosphatase 2A activator	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Serine/threonine-protein phosphatase 2A activator
Q15369	ELOC;TCEB1 Elongin-C	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Elongin-C
Q15370	ELOB;TCEB2 Elongin-B	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Elongin-B
Q15386	UBE3C;KIAA0010;KIAA10 Ubiquitin-protein ligase E3C	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Ubiquitin-protein ligase E3C
Q15843	NEDD8 NEDD8	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Ubiquitin-like protein NEDD8
Q16531	DDB1;XAP1 DNA damage-binding protein 1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=DNA damage-binding protein 1
Q16576	RBBP7;RBAP46 Histone-binding protein RBBP7	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Histone-binding protein RBBP7
Q5T4S7	UBR4;KIAA0462;KIAA1307;RBAF600;ZUBR1 E3 ubiquitin-protein ligase UBR4	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase UBR4
Q63HN8	RNF213;ALO17;C17orf27;KIAA1554;KIAA1618;MYSTR E3 ubiquitin-protein ligase RNF213	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase RNF213
Q6UXN9	WDR82;SWD2;TMEM113;WDR82A;UNQ9342/PRO34047 WD repeat-containing protein 82	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=WD repeat-containing protein 82
Q6ZNB6	NFXL1;OZFP NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP)	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=NF-X1-type zinc finger protein NFXL1
Q7Z5L9	IRF2BP2 Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Interferon regulatory factor 2-binding protein 2
Q7Z6Z7	HUWE1;KIAA0312;KIAA1578;UREB1;HSPC272 E3 ubiquitin-protein ligase HUWE1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase HUWE1
Q86TM6	SYVN1;HRD1;KIAA1810 E3 ubiquitin-protein ligase synoviolin	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase synoviolin
Q8IWR1	TRIM59;RNF104;TRIM57;TSBF1 Tripartite motif-containing protein 59	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Tripartite motif-containing protein 59
Q8N5U6	RNF10;KIAA0262;RIE2 E3 ubiquitin-protein ligase RNF10	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase RNF10
Q8NI36	WDR36 WD repeat-containing protein 36	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=WD repeat-containing protein 36
Q8TEQ6	GEMIN5 Gem-associated protein 5	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Gem-associated protein 5
Q8WUA4	GTF3C2;KIAA0011 General transcription factor 3C polypeptide 2	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=General transcription factor 3C polypeptide 2
Q92844	TANK;ITRAF;TRAF2 TRAF family member-associated NF-kappa-B activator	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=TRAF family member-associated NF-kappa-B activator
Q92900	UPF1;KIAA0221;RENT1 Regulator of nonsense transcripts 1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Regulator of nonsense transcripts 1
Q96J02	ITCH E3 ubiquitin-protein ligase Itchy homolog	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase Itchy homolog
Q9BVC4	MLST8;GBL;LST8 Target of rapamycin complex subunit LST8	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Target of rapamycin complex subunit LST8
Q9BZK7	TBL1XR1;IRA1;TBLR1 F-box-like/WD repeat-containing protein TBL1XR1	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=F-box-like/WD repeat-containing protein TBL1XR1
Q9C037	TRIM4;RNF87 E3 ubiquitin-protein ligase TRIM4	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=E3 ubiquitin-protein ligase TRIM4
Q9C0J8	WDR33;WDC146 pre-mRNA 3' end processing protein WDR33	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=pre-mRNA 3' end processing protein WDR33
Q9H0A0	NAT10;ALP;KIAA1709 RNA cytidine acetyltransferase	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=RNA cytidine acetyltransferase
Q9NRL2	BAZ1A;ACF1;WCRF180;HSPC317 Bromodomain adjacent to zinc finger domain protein 1A	reported_binder	bindingdb_reported	Yes	No	low	BindingDB:BDBM50652793	medium ; target=Bromodomain adjacent to zinc finger domain protein 1A

Sources and Literature

Source	Source ID	Source URL	Download URL	DOI / PMID
BindingDB	BDBM50652793	Open	-	10.7270/Q22N5711 PMID: 29928781
PubChem	CID117602383	Open	-

Structure Files

Kind	Format	Status	Docking use	File / link	Preparation note
canonical_2d	SMILES	raw	Docking-ready	Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12	keep_bindingdb_unique
generated_3d	SDF	prepared	Docking-ready	public/e3_file/ligand_db/generated/BDB065426/BDB065426.sdf	Generated from canonical SMILES
generated_3d	MOL2	prepared	Docking-ready	public/e3_file/ligand_db/generated/BDB065426/BDB065426.mol2	Generated from canonical SMILES
docking_ready	PDBQT	prepared	Docking-ready	public/e3_file/ligand_db/generated/BDB065426/BDB065426.pdbqt	Generated from canonical SMILES
image	PNG	prepared	Reference	public/e3_file/ligand_db/generated/BDB065426/BDB065426.png	Generated from canonical SMILES
image	SVG	prepared	Reference	public/e3_file/ligand_db/generated/BDB065426/BDB065426.svg	Generated from canonical SMILES

Activity

Target	Source	Assay	Result	Potency	Literature	Records
Actin-related protein 2/3 complex subunit 1B O15143 E3 ligase component	BindingDB:BDBM50652793	Kd	51 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Adenylyl cyclase-associated protein 1 Q01518 E3 ligase component	BindingDB:BDBM50652793	Kd	62002 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Aurora kinase A O14965 E3 ligase component	BindingDB:BDBM50652793	Kd	3297 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Bromodomain adjacent to zinc finger domain protein 1A Q9NRL2 E3 ligase component	BindingDB:BDBM50652793	Kd	19 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
CDK-activating kinase assembly factor MAT1 P51948 E3 ligase component	BindingDB:BDBM50652793	Kd	2985 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Cell division cycle protein 16 homolog Q13042 E3 ligase component	BindingDB:BDBM50652793	Kd	68 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Chromodomain-helicase-DNA-binding protein 3 Q12873 E3 ligase component	BindingDB:BDBM50652793	Kd	1347 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Chromodomain-helicase-DNA-binding protein 4 Q14839 E3 ligase component	BindingDB:BDBM50652793	Kd	615 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Coatomer subunit alpha P53621 E3 ligase component	BindingDB:BDBM50652793	Kd	652 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Coatomer subunit beta' P35606 E3 ligase component	BindingDB:BDBM50652793	Kd	291 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Coronin-1A P31146 E3 ligase component	BindingDB:BDBM50652793	Kd	51 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Cullin-1 Q13616 E3 ligase component	BindingDB:BDBM50652793	Kd	5.1 nM	Very high	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Cullin-2 Q13617 E3 ligase component	BindingDB:BDBM50652793	Kd	2512 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Cullin-3 Q13618 E3 ligase component	BindingDB:BDBM50652793	Kd	861 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Cytoplasmic dynein 1 intermediate chain 2 Q13409 E3 ligase component	BindingDB:BDBM50652793	Kd	2.4 nM	Very high	DOI: 10.7270/Q22N5711 PMID: 29928781	1
DDB1- and CUL4-associated factor 7 P61962 E3 ligase component	BindingDB:BDBM50652793	Kd	165 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
DNA damage-binding protein 1 Q16531 E3 ligase component	BindingDB:BDBM50652793	Kd	139 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 SUMO-protein ligase RanBP2 P49792 E3 ligase component	BindingDB:BDBM50652793	Kd	38797 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase HUWE1 Q7Z6Z7 E3 ligase component	BindingDB:BDBM50652793	Kd	3186 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase Itchy homolog Q96J02 E3 ligase component	BindingDB:BDBM50652793	Kd	6517 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase listerin O94822 E3 ligase component	BindingDB:BDBM50652793	Kd	753 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase makorin-3 Q13064 E3 ligase component	BindingDB:BDBM50652793	Kd	206284 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase MYCBP2 O75592 E3 ligase component	BindingDB:BDBM50652793	Kd	6.2 nM	Very high	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase RNF10 Q8N5U6 E3 ligase component	BindingDB:BDBM50652793	Kd	16662 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase RNF213 Q63HN8 E3 ligase component	BindingDB:BDBM50652793	Kd	595 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase synoviolin Q86TM6 E3 ligase component	BindingDB:BDBM50652793	Kd	7.3 nM	Very high	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase TRIM4 Q9C037 E3 ligase component	BindingDB:BDBM50652793	Kd	141 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin-protein ligase UBR4 Q5T4S7 E3 ligase component	BindingDB:BDBM50652793	Kd	593 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 ubiquitin/ISG15 ligase TRIM25 Q14258 E3 ligase component	BindingDB:BDBM50652793	Kd	53 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
E3 UFM1-protein ligase 1 O94874 E3 ligase component	BindingDB:BDBM50652793	Kd	16 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Elongin-B Q15370 E3 ligase component	BindingDB:BDBM50652793	Kd	25529 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Elongin-C Q15369 E3 ligase component	BindingDB:BDBM50652793	Kd	682 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Eukaryotic translation initiation factor 3 subunit I Q13347 E3 ligase component	BindingDB:BDBM50652793	Kd	35486 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
F-box-like/WD repeat-containing protein TBL1XR1 Q9BZK7 E3 ligase component	BindingDB:BDBM50652793	Kd	5.3 nM	Very high	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Gem-associated protein 5 Q8TEQ6 E3 ligase component	BindingDB:BDBM50652793	Kd	232 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
General transcription factor 3C polypeptide 2 Q8WUA4 E3 ligase component	BindingDB:BDBM50652793	Kd	14 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 P62873 E3 ligase component	BindingDB:BDBM50652793	Kd	2553 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Histone-binding protein RBBP4 Q09028 E3 ligase component	BindingDB:BDBM50652793	Kd	458 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Histone-binding protein RBBP7 Q16576 E3 ligase component	BindingDB:BDBM50652793	Kd	44399 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Interferon regulatory factor 2-binding protein 2 Q7Z5L9 E3 ligase component	BindingDB:BDBM50652793	Kd	84 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Interleukin-1 receptor-associated kinase 1 P51617 E3 ligase component	BindingDB:BDBM50652793	Kd	29 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Mitogen-activated protein kinase kinase kinase 1 Q13233 E3 ligase component	BindingDB:BDBM50652793	Kd	1925 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Mitotic checkpoint protein BUB3 O43684 E3 ligase component	BindingDB:BDBM50652793	Kd	68 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
mRNA export factor RAE1 P78406 E3 ligase component	BindingDB:BDBM50652793	Kd	7 nM	Very high	DOI: 10.7270/Q22N5711 PMID: 29928781	1
NF-X1-type zinc finger protein NFXL1 Q6ZNB6 E3 ligase component	BindingDB:BDBM50652793	Kd	3185 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Poly [ADP-ribose] polymerase 1 P09874 E3 ligase component	BindingDB:BDBM50652793	Kd	83 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
pre-mRNA 3' end processing protein WDR33 Q9C0J8 E3 ligase component	BindingDB:BDBM50652793	Kd	34 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Protein SEC13 homolog P55735 E3 ligase component	BindingDB:BDBM50652793	Kd	4.9 nM	Very high	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Regulator of nonsense transcripts 1 Q92900 E3 ligase component	BindingDB:BDBM50652793	Kd	24 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
RNA cytidine acetyltransferase Q9H0A0 E3 ligase component	BindingDB:BDBM50652793	Kd	235 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
RNA-binding protein FUS P35637 E3 ligase component	BindingDB:BDBM50652793	Kd	37 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
S-phase kinase-associated protein 2 Q13309 E3 ligase component	BindingDB:BDBM50652793	Kd	2.4 nM	Very high	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Sequestosome-1 Q13501 E3 ligase component	BindingDB:BDBM50652793	Kd	242 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Serine/threonine-protein kinase LATS1 O95835 E3 ligase component	BindingDB:BDBM50652793	Kd	69 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform P63151 E3 ligase component	BindingDB:BDBM50652793	Kd	377 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Serine/threonine-protein phosphatase 2A activator Q15257 E3 ligase component	BindingDB:BDBM50652793	Kd	136516 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Target of rapamycin complex subunit LST8 Q9BVC4 E3 ligase component	BindingDB:BDBM50652793	Kd	2144 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
TNF receptor-associated factor 2 Q12933 E3 ligase component	BindingDB:BDBM50652793	Kd	566 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
TRAF family member-associated NF-kappa-B activator Q92844 E3 ligase component	BindingDB:BDBM50652793	Kd	32 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Transcription intermediary factor 1-beta Q13263 E3 ligase component	BindingDB:BDBM50652793	Kd	79 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Tripartite motif-containing protein 59 Q8IWR1 E3 ligase component	BindingDB:BDBM50652793	Kd	5.8 nM	Very high	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Ubiquitin carboxyl-terminal hydrolase isozyme L1 P09936 E3 ligase component	BindingDB:BDBM50652793	Kd	106 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Ubiquitin conjugation factor E4 A Q14139 E3 ligase component	BindingDB:BDBM50652793	Kd	322 nM	Moderate	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Ubiquitin-like protein NEDD8 Q15843 E3 ligase component	BindingDB:BDBM50652793	Kd	27968 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
Ubiquitin-protein ligase E3C Q15386 E3 ligase component	BindingDB:BDBM50652793	Kd	83 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
WD repeat-containing protein 1 O75083 E3 ligase component	BindingDB:BDBM50652793	Kd	82 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
WD repeat-containing protein 36 Q8NI36 E3 ligase component	BindingDB:BDBM50652793	Kd	1127 nM	Low	DOI: 10.7270/Q22N5711 PMID: 29928781	1
WD repeat-containing protein 5 P61964 E3 ligase component	BindingDB:BDBM50652793	Kd	36 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1
WD repeat-containing protein 82 Q6UXN9 E3 ligase component	BindingDB:BDBM50652793	Kd	47 nM	High	DOI: 10.7270/Q22N5711 PMID: 29928781	1