| E3 UniProt | Gene / protein | Relation type | Ligand role | Direct | Functional | Docking | Source | Evidence |
|---|---|---|---|---|---|---|---|---|
| Q96SW2 | CRBN;AD-006 Protein cereblon |
recruiter | full_protac | Yes | Yes | exclude | PubChem:CID166077922 | high ARV-393 recruits CRBN to induce BCL6 ubiquitination and degradation. Docking is disabled until authoritative complete stereochemistry is available. |
| Kind | Format | Status | Docking use | File / link | Preparation note |
|---|---|---|---|---|---|
| canonical_2d | SMILES | not_needed | Reference | CNC(=O)COc1cc2cc(Nc3nc(N4CCC(OC5CC(N6CCC(c7ccc8c(c7F)CN(C7CCC(=O)NC7=O)C8=O)CC6)C5)CC4)ncc3Cl)ccc2n(C(C)C)c1=O | Canonical structure; PubChem does not specify stereochemistry for all possible centers. |
| generated_3d | SDF | prepared | Local 3D input | public/compound_structures/ligand_db/generated/LIG002009/LIG002009.sdf | Representative 3D visualization generated from PubChem connectivity; public stereochemistry is incomplete, so docking is disabled. |
| Target | Source | Assay | Result | Potency | Literature | Records |
|---|---|---|---|---|---|---|
|
BCL6 P41182 Neo-substrate |
PubChem:CID166077922 | other | - | - | 1 |