E3 Ligase Ligand Database

MGD and E3 ligand related compounds for browsing and docking.
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Structure similarity search Input SMILES or upload SDF/MOL/MOL2/PDB/PDBQT; results use Morgan fingerprint Tanimoto.
67228 compounds match the current filters. 123739 source records are linked to them.
Compound ID Name Formula / MW InChIKey E3 Target Source Docking structure
E3L058261
BDB058261
 BDBM50506387
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C2CC2)C1=O
 C28H30N4O5
502.571000		 XULAAAMSGNSTKH-NEKDWFFYSA-N Q09472 Histone acetyltransferase p300
BindingDB, PubChem
BindingDB:BDBM50506387; PubChem:CID146205184
 Local ready
Direct docking supported
E3L058262
BDB058262
 BDBM50506388
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3C[C@H]2C)C1=O
 C25H26N4O5
462.506000		 BLKBFXXCUQRTSO-SGANQWHYSA-N Q09472 Histone acetyltransferase p300
BindingDB, PubChem
BindingDB:BDBM50506388; PubChem:CID155512196
 Local ready
Direct docking supported
E3L058263
BDB058263
 BDBM50506389
CNC(=O)Nc1ccc2c(c1)CC[C@]21NC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O
 C27H28FN5O5
521.549000		 SZDFQTQSZKMHLZ-IDISGSTGSA-N Q09472 Histone acetyltransferase p300
BindingDB
BindingDB:BDBM50506389
 Local ready
Direct docking supported
E3L058264
BDB058264
 BDBM50506390
CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C(F)(F)F)C1=O
 C26H25F3N4O5
530.503000		 IBPGRSASCGUKNK-CPJSRVTESA-N Q09472 Histone acetyltransferase p300
BindingDB
BindingDB:BDBM50506390
 Local ready
Direct docking supported
E3L058265
BDB058265
 BDBM50506484
CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(N)=O)[C@@H](C)O
 C81H121N19O25
1760.967000		 MHJMWGHHTJSALQ-HKCFROBDSA-N O15151, Q00987 E3 ubiquitin-protein ligase Mdm2, Protein Mdm4
BindingDB, PubChem
BindingDB:BDBM50506484; PubChem:CID155546101
 Local ready
Direct docking supported
E3L058266
BDB058266
 BDBM50506485
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC1CCCCC1)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(=O)(=O)c1ccc(Cl)cc1
 C80H130ClN17O24S7
1973.937000		 OUQCUNMLUOHMCL-BEXZXKHESA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB
BindingDB:BDBM50506485
 Local ready
Direct docking supported
E3L058267
BDB058267
 BDBM50506486
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)CN(S(C)(=O)=O)CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(=O)(=O)CCCC/C=C/CCCCS1(=O)=O)S(C)(=O)=O)S(=O)(=O)c1ccc(Cl)cc1
 C85H138ClN17O24S7
2042.056000		 RPRWHESIZCGUBR-NEMOMTKUSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB
BindingDB:BDBM50506486
 Local ready
Direct docking supported
E3L058268
BDB058268
 BDBM50506487
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC1CCC1)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(=O)(=O)c1ccc(Cl)cc1
 C78H126ClN17O24S7
1945.883000		 FEPGCCQAGSSWRN-FBVSLTPNSA-N O15151, Q00987 E3 ubiquitin-protein ligase Mdm2, Protein Mdm4
BindingDB
BindingDB:BDBM50506487
 Local ready
Direct docking supported
E3L058269
BDB058269
 BDBM50506488
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)CN(S(C)(=O)=O)CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(=O)(=O)CC/C=C/CCCCS1(=O)=O)S(C)(=O)=O)S(=O)(=O)c1ccc(Cl)cc1
 C83H134ClN17O24S7
2014.002000		 KBUFEZZQKFCQEP-SGNBYVAPSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB
BindingDB:BDBM50506488
 Local ready
Direct docking supported
E3L058270
BDB058270
 BDBM50506489
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O
 C74H127N17O26S7
1895.392000		 LZRRVSVOYBXONM-UTRSQHICSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB
BindingDB:BDBM50506489
 Local ready
Direct docking supported
E3L058271
BDB058271
 BDBM50506490
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O
 C72H125N17O24S7
1837.356000		 UOKUFCYHTGHLQT-BOYGMGBESA-N O15151, Q00987 E3 ubiquitin-protein ligase Mdm2, Protein Mdm4
BindingDB
BindingDB:BDBM50506490
 Local ready
Direct docking supported
E3L058272
BDB058272
 BDBM50506491
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(=O)(=O)c1ccc(Cl)cc1
 C77H126ClN17O24S7
1933.872000		 HLACHACEIOQHPF-JFPIBWRESA-N O15151, Q00987 E3 ubiquitin-protein ligase Mdm2, Protein Mdm4
BindingDB
BindingDB:BDBM50506491
 Local ready
Direct docking supported
E3L058273
BDB058273
 BDBM50506492
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(=O)(=O)c1ccc(Cl)cc1)S(C)(=O)=O)S(C)(=O)=O
 C77H126ClN17O24S7
1933.872000		 PQXZUIONIKLWJT-JFPIBWRESA-N Q00987 E3 ubiquitin-protein ligase Mdm2
BindingDB
BindingDB:BDBM50506492
 Local ready
Direct docking supported
E3L058274
BDB058274
 BDBM50506493
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](C)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(=O)(=O)c1ccc(Cl)cc1
 C69H121ClN16O24S7
1818.737000		 VOAWXEAFJWXBIH-VTCHJHGHSA-N Q00987 E3 ubiquitin-protein ligase Mdm2
BindingDB
BindingDB:BDBM50506493
 Local ready
Direct docking supported
E3L058275
BDB058275
 BDBM50506494
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](C)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O
 C75H131N17O24S7
1879.437000		 RNEQXJKWOPHHAT-QZFUHSARSA-N Q00987 E3 ubiquitin-protein ligase Mdm2
BindingDB
BindingDB:BDBM50506494
 Local ready
Direct docking supported
E3L058276
BDB058276
 BDBM50506495
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](CO)CN(CC(N)=O)S(C)(=O)=O)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O
 C72H125N17O25S7
1853.355000		 SURHUULKDKWNMB-HTDFSDFJSA-N Q00987 E3 ubiquitin-protein ligase Mdm2
BindingDB
BindingDB:BDBM50506495
 Local ready
Direct docking supported
E3L058277
BDB058277
 BDBM50506496
CC(=O)N[C@@H](CC(C)C)CN(CC(=O)N[C@@H](Cc1ccccc1)CN(CC(=O)N[C@@H](CCC(=O)O)CN(CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)CN(CC(=O)N[C@@H](CCCCN)CN(CC(=O)N[C@@H](CC(C)C)CN(CC(N)=O)S(=O)(=O)CC(C)C)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O)S(C)(=O)=O
 C66H113N15O21S6
1645.116000		 SJSCVONYWXSWQT-VICXIOLRSA-N Q00987 E3 ubiquitin-protein ligase Mdm2
BindingDB
BindingDB:BDBM50506496
 Local ready
Direct docking supported
E3L058278
BDB058278
 BDBM50506637
CC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(N4Cc5cccc(N(C)S(C)(=O)=O)c5C4)n3)cc2)CC1
 C27H30F3N7O3S
589.644000		 OIXHMSMLJCOUJT-UHFFFAOYSA-N O14965 Aurora kinase A
BindingDB, PubChem
BindingDB:BDBM50506637; PubChem:CID155538441
 Local ready
Direct docking supported
E3L058279
BDB058279
 BDBM50506700
O=C(Cc1ccc(-c2ccccc2)cc1)Nc1cc(C2CCC2)[nH]n1
 C21H21N3O
331.419000		 DTNFOGMAASDEQI-UHFFFAOYSA-N O14965 Aurora kinase A
BindingDB, PubChem
BindingDB:BDBM50506700; PubChem:CID69762142
 Local ready
Direct docking supported
E3L058280
BDB058280
 PRMT5-IN-4b14
N#Cc1c(Br)cccc1NC(=O)CCN1CCc2ccccc2C1
 C19H18BrN3O
384.277000		 RFPVZTZIBYRPGW-UHFFFAOYSA-N Q9BQA1 Protein arginine N-methyltransferase 5
BindingDB, PubChem
BindingDB:BDBM50506814; PubChem:CID155538900
 Local ready
Direct docking supported