E3 Ligase Ligand Database

MGD and E3 ligand related compounds for browsing and docking.
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Structure similarity search Input SMILES or upload SDF/MOL/MOL2/PDB/PDBQT; results use Morgan fingerprint Tanimoto.
67228 compounds match the current filters. 123739 source records are linked to them.
Compound ID Name Formula / MW InChIKey E3 Target Source Docking structure
E3L064801
BDB064801
 BDBM50639195
CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCCNC(=O)C[C@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC1=O
 C63H102N16O20
1403.601000		 SBEDHSKHWZKIJE-KUUIKYMGSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639195; PubChem:CID177376397
 Local ready
Direct docking supported
E3L064802
BDB064802
 H-Lys(1)-Trp-Asp-Glu-Glu-Thr-Gly-Glu-Gln-(1)
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O
 C47H66N12O19
1103.110000		 OJIXCTWYAARPLN-MLZIFKSBSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639196; PubChem:CID177376398
 Local ready
Direct docking supported
E3L064803
BDB064803
 BDBM50639197
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCCNC1=O)C(N)=O
 C57H87N13O21
1290.393000		 OIVYZCPDIQLCJS-IFDADTEJSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639197; PubChem:CID177376399
 Local ready
Direct docking supported
E3L064804
BDB064804
 BDBM50639198
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCCNC1=O)C(N)=O
 C56H85N13O21
1276.366000		 OUVHQIQBYQZDJD-ASIUHSGJSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639198; PubChem:CID177376400
 Local ready
Direct docking supported
E3L064805
BDB064805
 BDBM50639199
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)CCCCNC1=O)C(N)=O
 C55H83N13O21
1262.339000		 ANKQCHLQGGKNBJ-FDTYECOMSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639199; PubChem:CID177376401
 Local ready
Direct docking supported
E3L064806
BDB064806
 BDBM50639200
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCCNC1=O)C(N)=O
 C56H85N13O22
1292.365000		 RCAGOLNKZCTEPZ-UOEWMARJSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639200; PubChem:CID177376402
 Local ready
Direct docking supported
E3L064807
BDB064807
 H-Lys(1)-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Glu-(1)
CC(C)C[C@@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O
 C42H66N10O20
1031.040000		 KVBYBXKGCDSJNR-LHAREUDBSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639201; PubChem:CID177376403
 Local ready
Direct docking supported
E3L064808
BDB064808
 Keap1-Nrf2-IN-20
CC(C)C[C@@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 FUCFCQJDVXDRBH-LHAREUDBSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639202; PubChem:CID171391751
 Local ready
Direct docking supported
E3L064809
BDB064809
 H-Lys(1)-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Glu(1)-NH2
CC(C)C[C@@H]1NC(=O)[C@@H](N)CCCCNC(=O)CC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 DDAKHSPNQQCYHZ-LHAREUDBSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639203; PubChem:CID177376404
 Local ready
Direct docking supported
E3L064810
BDB064810
 H-Lys(1)-D-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Gln-(1)
CC(C)C[C@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 FUCFCQJDVXDRBH-QPUXBDTESA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639204; PubChem:CID177376405
 Local ready
Direct docking supported
E3L064811
BDB064811
 H-Lys(1)-Leu-D-Asp-Glu-Glu-Thr-Gly-Glu-Gln-(1)
CC(C)C[C@@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 FUCFCQJDVXDRBH-XUUMBCHKSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639205; PubChem:CID177376406
 Local ready
Direct docking supported
E3L064812
BDB064812
 H-Lys(1)-D-Leu-D-Asp-Glu-Glu-Thr-Gly-Glu-Gln-(1)
CC(C)C[C@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 FUCFCQJDVXDRBH-DTJSJNLJSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639206; PubChem:CID177376407
 Local ready
Direct docking supported
E3L064813
BDB064813
 H-Lys(1)-Leu-Asp-D-Glu-Glu-Thr-Gly-Glu-Gln-(1)
CC(C)C[C@@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 FUCFCQJDVXDRBH-FRXUXRSISA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639207; PubChem:CID177376408
 Local ready
Direct docking supported
E3L064814
BDB064814
 H-Lys(1)-Leu-Asp-Glu-D-Glu-Thr-Gly-Glu-Gln-(1)
CC(C)C[C@@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 FUCFCQJDVXDRBH-MBMYHTPJSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639208; PubChem:CID177376409
 Local ready
Direct docking supported
E3L064815
BDB064815
 H-Lys(1)-Leu-Asp-Glu-Glu-Thr-Gly-D-Glu-Gln-(1)
CC(C)C[C@@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 FUCFCQJDVXDRBH-DCWBAGHISA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639209; PubChem:CID177376410
 Local ready
Direct docking supported
E3L064816
BDB064816
 H-Lys(1)-Leu-Asp-Glu-D-Glu-D-aThr-Gly-D-Glu-Gln-(1)
CC(C)C[C@@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 FUCFCQJDVXDRBH-QVROBHNXSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639210; PubChem:CID177376411
 Local ready
Direct docking supported
E3L064817
BDB064817
 BDBM50639211
CC(C)C[C@H]1NC(=O)[C@@H](N)CCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]([C@@H](C)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC1=O
 C42H67N11O19
1030.056000		 FUCFCQJDVXDRBH-VFLUMXDPSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639211; PubChem:CID177376412
 Local ready
Direct docking supported
E3L064818
BDB064818
 H-Lys(1)-Asp-Pro-Glu-Thr-Gly-gGlu(1)-Phe-Leu-NH2
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC[C@@H]1NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCNC1=O)C(N)=O
 C46H69N11O15
1016.120000		 STMYBFPIMPHDKC-NEIDLHSQSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50639212; PubChem:CID177376413
 Local ready
Direct docking supported
E3L064819
BDB064819
 BDBM50639638
O=C1CCC2(CC(c3ccccc3Cl)=NO2)C(=O)N1
 C13H11ClN2O3
278.695000		 BUCCPXBJMQOJMQ-UHFFFAOYSA-N Q96SW2 Protein cereblon
BindingDB, PubChem
BindingDB:BDBM50639638; PubChem:CID177376698
 Local ready
Direct docking supported
E3L064820
BDB064820
 BDBM50639639
O=C1CCC2(CC(c3ccc(Cl)cc3Cl)=NO2)C(=O)N1
 C13H10Cl2N2O3
313.140000		 KFAVXUHSPFYSLI-UHFFFAOYSA-N Q96SW2 Protein cereblon
BindingDB, PubChem
BindingDB:BDBM50639639; PubChem:CID177376699
 Local ready
Direct docking supported