E3 Ligase Ligand Database

MGD and E3 ligand related compounds for browsing and docking.
Reset
Structure similarity search Input SMILES or upload SDF/MOL/MOL2/PDB/PDBQT; results use Morgan fingerprint Tanimoto.
67228 compounds match the current filters. 123739 source records are linked to them.
Compound ID Name Formula / MW InChIKey E3 Target Source Docking structure
E3L060221
BDB060221
 Ac-Leu-Asp-Pro-Glu-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C48H72N10O17
1061.157000		 HCVJWWNZLZOHHB-BMISOUISSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547514; PubChem:CID162649210
 Local ready
Direct docking supported
E3L060222
BDB060222
 BDBM50547515
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C48H71FN10O17
1079.147000		 MJEZTVMHFYSIRB-UVDYPLADSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547515
 Local ready
Direct docking supported
E3L060223
BDB060223
 Ac-Leu-Asp-Thz-Glu-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1CSC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C47H70N10O17S
1079.197000		 QXANBJCYGDZXAS-MCWAAHJHSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547516; PubChem:CID162660460
 Local ready
Direct docking supported
E3L060224
BDB060224
 Ac-Leu-Asp-Glu-Gln-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C48H73N11O18
1092.171000		 AADUGBJHXZETSU-PRDVVYQQSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547517; PubChem:CID162652777
 Local ready
Direct docking supported
E3L060225
BDB060225
 Ac-Leu-Asp-Glu-Tyr-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C52H74N10O18
1127.216000		 ATUNBSMOYSKFOO-JYOBDFOLSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547518; PubChem:CID162658754
 Local ready
Direct docking supported
E3L060226
BDB060226
 Ac-Leu-Asp-Glu-Hse-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCO)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C47H72N10O18
1065.145000		 NBWFNTKMIVTHAQ-MCWAAHJHSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547519; PubChem:CID162654085
 Local ready
Direct docking supported
E3L060227
BDB060227
 Ac-Leu-Asp-Glu-Tyr(3-OH)-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C52H74N10O19
1143.215000		 JMFSIDOLTGMGQR-AHVWZTQISA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547520; PubChem:CID162666022
 Local ready
Direct docking supported
E3L060228
BDB060228
 Ac-Leu-Asp-Glu-Phe(3,4-diOMe)-Thr-Gly-Glu-Phe-Leu-NH2
COc1ccc(C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O)cc1OC
 C54H78N10O19
1171.269000		 FIYITNDKSBNBHY-BHPBEYFWSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547521; PubChem:CID162649256
 Local ready
Direct docking supported
E3L060229
BDB060229
 Ac-Leu-Asp-Glu-4Pal-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C51H73N11O17
1112.205000		 SFKIXWLVRMIELZ-FBCVKHONSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547522; PubChem:CID162672761
 Local ready
Direct docking supported
E3L060230
BDB060230
 Ac-Leu-Asp-Glu-Trp(5-OH)-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C54H75N11O18
1166.253000		 SNCCWGKUPVEQRT-PZKZGSKYSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547523; PubChem:CID162664294
 Local ready
Direct docking supported
E3L060231
BDB060231
 Ac-Leu-Asp-Glu-hPhe-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCc1ccccc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C53H76N10O17
1125.244000		 AOGLCKQYYGTGOG-GKSBGNNDSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547524; PubChem:CID162665123
 Local ready
Direct docking supported
E3L060232
BDB060232
 Ac-Leu-Asp-Glu-2Nal-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C56H76N10O17
1161.277000		 QZZHSKRXZXPYML-NVQHVLMFSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547525; PubChem:CID162671770
 Local ready
Direct docking supported
E3L060233
BDB060233
 Ac-Leu-Asp-Glu-Bpa-Thr-Gly-Glu-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C59H78N10O18
1215.325000		 SDRDEYMXVUFOFE-CAPQXUEYSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547526; PubChem:CID162662652
 Local ready
Direct docking supported
E3L060234
BDB060234
 BDBM50547527
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O
 C47H69FN10O17
1065.120000		 HUSABMWTCSZHFW-AGQURRGHSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547527
 Local ready
Direct docking supported
E3L060235
BDB060235
 BDBM50547528
CC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1C[C@H](F)CN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O
 C48H71FN10O16
1063.148000		 SYGRRFRZYBTSIX-VXJRNSOOSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547528
 Local ready
Direct docking supported
E3L060236
BDB060236
 BDBM50547529
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)(C)O
 C49H73FN10O17
1093.174000		 BTXOPVJSXZAEBF-IAXYMDMUSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547529
 Local ready
Direct docking supported
E3L060237
BDB060237
 BDBM50547530
CC[C@H](O)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1C[C@H](F)CN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O
 C49H73FN10O17
1093.174000		 OXUIASJUENVQRU-JAVCLAKKSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547530
 Local ready
Direct docking supported
E3L060238
BDB060238
 BDBM50547531
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O
 C53H73FN10O16
1125.219000		 LRYNWXMKVRVIFJ-JBRKIFEHSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547531
 Local ready
Direct docking supported
E3L060239
BDB060239
 BDBM50547532
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)C(O)c1ccccc1
 C53H73FN10O17
1141.218000		 RWORTDYWPPCMQW-YQAARSKESA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547532
 Local ready
Direct docking supported
E3L060240
BDB060240
 BDBM50547533
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C45H67FN10O15
1007.084000		 HLAUDNCPVIQLIS-SDMRNOOHSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547533
 Local ready
Direct docking supported