E3 Ligase Ligand Database

MGD and E3 ligand related compounds for browsing and docking.
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Structure similarity search Input SMILES or upload SDF/MOL/MOL2/PDB/PDBQT; results use Morgan fingerprint Tanimoto.
67228 compounds match the current filters. 123739 source records are linked to them.
Compound ID Name Formula / MW InChIKey E3 Target Source Docking structure
E3L060241
BDB060241
 BDBM50547534
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@H](O)c1ccccc1
 C50H69FN10O15
1069.155000		 YOXJKUWKRDPINH-DYMZDMDDSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547534
 Local ready
Direct docking supported
E3L060242
BDB060242
 Ac-Leu-Asp-Glu-Glu-Thr-Gly-Gln-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C48H73N11O18
1092.171000		 HSIQAAQDWAGIJF-PRDVVYQQSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547535; PubChem:CID162656608
 Local ready
Direct docking supported
E3L060243
BDB060243
 Ac-Leu-Asp-Glu-Glu-Thr-Gly-Tyr-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C52H74N10O18
1127.216000		 ULETYQCOCNMJNZ-JYOBDFOLSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547536; PubChem:CID162671613
 Local ready
Direct docking supported
E3L060244
BDB060244
 Ac-Leu-Asp-Glu-Glu-Thr-Gly-Hse-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C47H72N10O18
1065.145000		 PTYQWLBDUKADPV-MCWAAHJHSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547537; PubChem:CID162650135
 Local ready
Direct docking supported
E3L060245
BDB060245
 Ac-Leu-Asp-Glu-Glu-Thr-Gly-Nle(MeOH)(MeOH)-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCCO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C50H78N10O18
1107.226000		 CBEUWYBLXVRHHI-HGUCRSPMSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547538; PubChem:CID162660149
 Local ready
Direct docking supported
E3L060246
BDB060246
 Ac-Leu-Asp-Glu-Glu-Thr-Gly-Phe(4-CONH2)-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1ccc(C(N)=O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C53H75N11O18
1154.242000		 CYUXHNATKXBULP-JYOBDFOLSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547539; PubChem:CID162663514
 Local ready
Direct docking supported
E3L060247
BDB060247
 Ac-Leu-Asp-Glu-Glu-Thr-Gly-Phe(3-F)-Phe-Leu-NH2
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1cccc(F)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)O
 C52H73FN10O17
1129.207000		 ICYWYTARNDQPPO-JYOBDFOLSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB, PubChem
BindingDB:BDBM50547540; PubChem:CID162648108
 Local ready
Direct docking supported
E3L060248
BDB060248
 BDBM50547541
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)c1ccccc1)[C@@H](C)O
 C51H71FN10O15
1083.182000		 IDSBAIHZBKXHQP-GFDCGGGJSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547541
 Local ready
Direct docking supported
E3L060249
BDB060249
 BDBM50547542
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O)c1cc(F)cc(F)c1)[C@@H](C)O
 C51H69F3N10O15
1119.162000		 VUMPGMHKDSPCGB-KMXCKTRQSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547542
 Local ready
Direct docking supported
E3L060250
BDB060250
 BDBM50547543
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O
 C27H38FN7O14
703.634000		 JFIGJVPPVXCCFS-RTCSFYESSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547543
 Local ready
Direct docking supported
E3L060251
BDB060251
 BDBM50547544
CC(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1C[C@@H](F)C[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(N)=O)[C@@H](C)O
 C29H43FN8O15
762.702000		 LMAKZEVZUHQCKN-XCQPDQAKSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547544
 Local ready
Direct docking supported
E3L060252
BDB060252
 BDBM50547545
C[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC1=O
 C28H40FN7O14
717.661000		 NFOLPZGLVDULJK-RARHVDORSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547545
 Local ready
Direct docking supported
E3L060253
BDB060253
 BDBM50547546
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)C(=O)[C@H]2CCCN2C(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O
 C30H41FN6O14
728.684000		 SSLASVOSWQTHGN-WEBLYYDWSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547546
 Local ready
Direct docking supported
E3L060254
BDB060254
 BDBM50547547
C[C@@H](O)[C@@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(=O)O)NC(=O)CNC1=O
 C30H41FN6O14
728.684000		 SSLASVOSWQTHGN-OYFUIKIGSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547547
 Local ready
Direct docking supported
E3L060255
BDB060255
 BDBM50547548
CC(=O)N[C@H]1CSSC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O
 C33H48FN9O16S2
909.926000		 IIAJDSFFRAWWGO-BHXATAKGSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547548
 Local ready
Direct docking supported
E3L060256
BDB060256
 BDBM50547549
CC(=O)N[C@H]1CC(=O)NC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O
 C34H49FN10O17
888.817000		 DAOSPGSFZFEPDC-PVLKQLJCSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547549
 Local ready
Direct docking supported
E3L060257
BDB060257
 BDBM50547550
CC(=O)N[C@H]1CCC(=O)NC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O
 C35H51FN10O17
902.844000		 IREMLEOPZOVZAE-KIRNNDRUSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547550
 Local ready
Direct docking supported
E3L060258
BDB060258
 BDBM50547551
CC(=O)N[C@H]1CCC(=O)NCC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O
 C36H53FN10O17
916.871000		 NOMXIUIZHQSCQU-JEKVDGBVSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547551
 Local ready
Direct docking supported
E3L060259
BDB060259
 BDBM50547552
CC(=O)N[C@H]1CCCCn2cc(nn2)C[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O
 C38H55FN12O16
954.924000		 UUCQCBSUVYWPMO-SKAORLFQSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547552
 Local ready
Direct docking supported
E3L060260
BDB060260
 BDBM50547553
CC(=O)N[C@H]1Cc2cn(nn2)CCCC[C@@H](C(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]2C[C@H](F)CN2C(=O)[C@H](CC(=O)O)NC1=O
 C38H55FN12O16
954.924000		 ANLSYXPCDSYZSP-SKAORLFQSA-N Q14145 Kelch-like ECH-associated protein 1
BindingDB
BindingDB:BDBM50547553
 Local ready
Direct docking supported