| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L065841
LIG000411
|
16
CC(C)(c1ccc(OCC2CCN(C3CN(C(=O)CCCNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)cc1)c1ccc(OC[C@H](O)CCl)cc1
|
C44H52ClN5O8 814.380000 |
GASMQQMORKSVBV-OVFDOZPJSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1547
|
Local ready
Direct docking supported
|
|
E3L065842
LIG000412
|
Z3076458658
O=C1CCC(Nc2ncnc3cc(Br)sc23)C(=O)N1
|
C11H9BrN4O2S 341.190000 |
GAWRFJVTZFBLSO-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB897
|
Local ready
Direct docking supported
|
|
E3L065843
LIG000413
|
compound 18
O=C1CCC(n2cc(-c3csc(C(=O)N4CCCC4)c3)nn2)C(=O)N1
|
C16H17N5O3S 359.411000 |
GBBKINIQPVMNTN-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1047
|
Local ready
Direct docking supported
|
|
E3L065844
LIG000414
|
LYG-413
Cc1cccc2c1OCC(C(=O)NCc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)=C2
|
C25H23N3O5 445.475000 |
GBMLGLBBNNBKFK-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1356
|
Local ready
Direct docking supported
|
|
E3L065845
LIG000415
|
LIG000415
CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1C[C@H]2CC[C@@H]1N(CCc1ccccc1)C2)C1CCCCC1
|
C27H42N4O2 454.659000 |
GBQXNBCXOOCMBG-CFYMNZCRSA-N | Q13490 | - |
e3_ligand
e3_ligand:51
Related BindingDB:BDBM50364484
|
Local ready
Direct docking supported
|
|
E3L065846
LIG000416
|
LIG000416
CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1C[C@H]2CC[C@@H]1N(CCc1ccccc1)C2)C1CCCCC1
|
C27H42N4O2 454.659000 |
GBQXNBCXOOCMBG-CFYMNZCRSA-N | P98170 | - |
e3_ligand
e3_ligand:51
|
Local ready
Direct docking supported
|
|
E3L065847
LIG000417
|
22h
O=C1CCC(n2nnc3ccc(CNC(=O)Nc4ccc(C(F)(F)F)c(Cl)c4)cc3c2=O)C(=O)N1
|
C21H16ClF3N6O4 508.844000 |
GBYXYTXQRSFNMT-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB993
|
Local ready
Direct docking supported
|
|
E3L065848
LIG000418
|
28
CC(C)(c1ccc(OCc2ccccc2)cc1)c1cc(Cl)c(OCC2CCN(C(=O)CCCCNc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)c(C#N)c1
|
C47H48ClN5O7 830.382000 |
GCCBNMCNOBIBKC-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1559
|
Local ready
Direct docking supported
|
|
E3L065849
LIG000419
|
LYG-420
CC(C)(C)c1ccc2c(c1)C=C(C(=O)NCc1ccc3c(c1)CN(C1CCC(=O)NC1=O)C3=O)CO2
|
C28H29N3O5 487.556000 |
GCIPXKUQOMXSSF-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1363
|
Local ready
Direct docking supported
|
|
E3L065850
LIG000420
|
GBD-15
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@H]1CCCN(C(=O)CCCCCCCCCCCNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C1
|
C47H53N9O6 839.998000 |
GCTKAZBZZAIKCL-VGPLUOEVSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB834
|
Local ready
Direct docking supported
|
|
E3L065851
LIG000421
|
LC-02-120
O=C1CC[C@H](N2Cc3cc(-c4cnn5ccc(NC6CCOCC6)nc45)ccc3C2=O)C(=O)N1
|
C24H24N6O4 460.494000 |
GCUFXMIQFJJOPR-IBGZPJMESA-N | - | - |
MolGlueDB
MolGlueDB:MGDB921
|
Local ready
Direct docking supported
|
|
E3L065852
LIG000422
|
68
O=C1CCC(N2C(=O)c3cccc(NC(=O)c4ccccc4)c3C2=O)C(=O)N1
|
C20H15N3O5 377.356000 |
GCYCCBRTJYRRNK-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB974
|
Local ready
Direct docking supported
|
|
E3L065853
LIG000423
|
39
O=C1CCC(c2ccc(OCc3ccc(CN4CCOCC4)cc3)cc2)C(=O)N1
|
C23H26N2O4 394.471000 |
GCYQZUHXMWPHJQ-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB927
|
Local ready
Direct docking supported
|
|
E3L065854
LIG000424
|
14f
Cc1cc(C)c(SCC2CCC(=O)NC2=O)c(C)c1
|
C15H19NO2S 277.389000 |
GDGLHDANSQBSLX-UHFFFAOYSA-N | Q96SW2 | Protein cereblon |
BindingDB, MolGlueDB
BindingDB:BDBM50625124; MolGlueDB:MGDB304
|
Local ready
Direct docking supported
|
|
E3L065855
LIG000425
|
LIG000425
Cc1nc(C)c(-c2ccc(-c3c[nH]c([C@@H]4C[C@@H](O)CN4C(=O)[C@@H](N)C(C)(C)C)n3)cc2)s1
|
C24H31N5O2S 453.612000 |
GEUMUTSTKIRPRB-SLYNCCJLSA-N | P40337 | - |
e3_ligand
e3_ligand:86
|
Local ready
Direct docking supported
|
|
E3L065856
LIG000426
|
LIG000426
CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](c1cc(C)no1)C(C)C)c1ccc(C#N)cc1
|
C25H31N5O5 481.553000 |
GEWZUXIXBYUKKN-QTDGGUCWSA-N | P40337 | - |
e3_ligand
e3_ligand:31
|
Local ready
Direct docking supported
|
|
E3L065857
LIG000427
|
VH101
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1
|
C26H33FN4O4S 516.639000 |
GFNCBUDQFXZVNN-SVFBPWRDSA-N | P40337, Q15369 | von Hippel-Lindau disease tumor suppressor, Elongin-C |
BindingDB, e3_ligand
BindingDB:BDBM50459943; e3_ligand:14
|
Local ready
Direct docking supported
|
|
E3L065858
LIG000428
|
4
CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
|
C24H32N4O4S 472.611000 |
GFVIEZBZIUKYOG-SVFBPWRDSA-N | P40337, P62877, Q13617, Q15369, Q15370 | Hypoxia-inducible factor 1-alpha, von Hippel-Lindau disease tumor suppressor, Cullin-2, Elongin-C |
BindingDB, e3_ligand, MolGlueDB
BindingDB:BDBM50099062; e3_ligand:12; MolGlueDB:MGDB56
|
Local ready
Direct docking supported
|
|
E3L065859
LIG000429
|
17
CN1C(=O)CCC(N2Cc3cc(CNC(=O)Nc4ccc(F)cc4)ccc3C2=O)C1=O
|
C22H21FN4O4 424.432000 |
GGDWOJJZTPCYCF-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB534
|
Local ready
Direct docking supported
|
|
E3L065860
LIG000430
|
LIG000430
CC(=O)N1CCN(c2ccc3c(NCCN)nc(C4(c5ccc(Cl)cc5)CCCCC4)nc3c2)CC1
|
C28H35ClN6O 507.082000 |
GGEKTDCCHNVLNE-UHFFFAOYSA-N | Q66K64, Q9Y4B6 | DDB1- and CUL4-associated factor 15 |
BindingDB, e3_ligand
BindingDB:BDBM50627140; e3_ligand:106
Related BindingDB:BDBM50627138
|
Local ready
Direct docking supported
|