| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L066885
LIG001455
|
9
CC[C@H](CO)Nc1nc(NCc2ccc(-c3ccc(CC(C)C)cc3)cc2)c2ncn(C(C)C)c2n1
|
C29H38N6O 486.664000 |
TUCCBRXENVFDRS-RUZDIDTESA-N | - | - |
MolGlueDB
MolGlueDB:MGDB201
|
Local ready
Direct docking supported
|
|
E3L066886
LIG001456
|
LIG001456
COc1ccccc1C(=O)NC1CCC(=O)NC1=O
|
C13H14N2O4 262.265000 |
TUSFLMOPPKOJFD-UHFFFAOYSA-N | Q16531, Q96SW2 | DNA damage-binding protein 1 |
BindingDB, e3_ligand
BindingDB:BDBM733715; e3_ligand:101
|
Local ready
Direct docking supported
|
|
E3L066887
LIG001457
|
Entry 8
CN1CCN([C@@H]2CCCN(c3cnc(C(N)=O)c(Nc4ccc(C5CCN(C[C@H]6CC[C@H](Nc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)CC5)cc4)n3)C2)C1=O
|
C45H55N11O6 846.006000 |
TUUWHNYEHKKJLJ-JXULWJFASA-N | - | - |
MolGlueDB
MolGlueDB:MGDB567
|
Local ready
Direct docking supported
|
|
E3L066888
LIG001458
|
Entry 9
CN1CCN([C@@H]2CCCN(c3cnc(C(N)=O)c(Nc4ccc(C5CCN(C[C@H]6CC[C@@H](Nc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)CC5)cc4)n3)C2)C1=O
|
C45H55N11O6 846.006000 |
TUUWHNYEHKKJLJ-SUKSAIQQSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB566
|
Local ready
Direct docking supported
|
|
E3L066889
LIG001459
|
cmp29
O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccc(F)cn6)CC5)cc4)cccc3C2=O)C(=O)N1
|
C30H30FN5O4 543.599000 |
TVPVYTOUVYFZAQ-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1114
|
Local ready
Direct docking supported
|
|
E3L066890
LIG001460
|
FL2
O=C1CCC(N2C(=O)c3ccc(Nc4ccc(OS(=O)(=O)F)cc4)cc3C2=O)C(=O)N1
|
C19H14FN3O7S 447.400000 |
TVTRBQHZZSHTQW-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1011
|
Local ready
Direct docking supported
|
|
E3L066891
LIG001461
|
RG7388
COc1cc(C(=O)O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(c2ccc(Cl)cc2F)[C@H]1c1cccc(Cl)c1F
|
C31H29Cl2F2N3O4 616.492000 |
TVTXCJFHQKSQQM-LJQIRTBHSA-N | O15151, Q00987 | E3 ubiquitin-protein ligase Mdm2, Protein Mdm4 |
BindingDB, e3_ligand
BindingDB:BDBM50437206; e3_ligand:10
|
Local ready
Direct docking supported
|
|
E3L066892
LIG001462
|
19
COc1ccc(C(C)(C)c2ccc(OCC3CCN(C(=O)CCCCNc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)cc1
|
C40H46N4O7 694.829000 |
TVZWEKVQGLBANX-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1550
|
Local ready
Direct docking supported
|
|
E3L066893
LIG001463
|
23b
O=C1CCC(N2Cc3ccc(C4=C[C@@]4(COOCC(Cl)(Cl)Cl)c4ccc(Br)cc4)cc3C2=O)C(=O)N1
|
C25H20BrCl3N2O5 614.707000 |
TWEXZHMHUWLYIW-PIFIWZBESA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1238
|
Local ready
Direct docking supported
|
|
E3L066894
LIG001464
|
45
Cc1ccc(NC(=O)NCc2cccc(C3CCC(=O)NC3=O)c2)cc1Cl
|
C20H20ClN3O3 385.851000 |
TWQKQAWTRPKRGX-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB343
|
Local ready
Direct docking supported
|
|
E3L066895
LIG001465
|
C11
CCOC(=O)C1CCCN(C(=O)c2nn(-c3ccc(C)c(C)c3)c(=O)n(Cc3cc(C)cc(C)c3)c2=O)C1
|
C29H34N4O5 518.614000 |
TWVRWOOJIDAANX-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1441
|
Local ready
Direct docking supported
|
|
E3L066896
LIG001466
|
EM12-SO2Im
O=C1CCC(N2Cc3ccc(S(=O)(=O)n4ccnc4)cc3C2=O)C(=O)N1
|
C16H14N4O5S 374.378000 |
TXGIWHWNJZVUAC-UHFFFAOYSA-N | Q96SW2 | Protein cereblon |
BindingDB, MolGlueDB
BindingDB:BDBM50630771; MolGlueDB:MGDB1251
|
Local ready
Direct docking supported
|
|
E3L066897
LIG001467
|
60
Cn1ccc2cc(-c3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)ccc21
|
C22H17N3O4 387.395000 |
TXHVWIDFZDXIOP-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB559
|
Local ready
Direct docking supported
|
|
E3L066898
LIG001468
|
LIG001468
CNC(=O)C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)C1(C#N)CC1)C(C)(C)C)c1ccc(-c2scnc2C)cc1
|
C30H38N6O5S 594.738000 |
TXOUIGUFBKWBLO-HXKBJWFLSA-N | P40337 | von Hippel-Lindau disease tumor suppressor |
BindingDB, e3_ligand
BindingDB:BDBM50615681; e3_ligand:26
|
Local ready
Direct docking supported
|
|
E3L066899
LIG001469
|
GBD-11
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@H]1CCCN(C(=O)CCCCCCCCCNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)C1
|
C45H49N9O6 811.944000 |
TXQUGROTXYOXMO-BRKUKBBPSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB836
|
Local ready
Direct docking supported
|
|
E3L066900
LIG001470
|
12
CN(CCCCc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC1CCC(n2cc3cc(NC(=O)c4cccc(C(F)(F)F)n4)c(C(C)(C)O)cc3n2)CC1
|
C42H46F3N7O6 801.867000 |
TXXHHAICAYYMLP-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB519
Related BindingDB:BDBM50639838
|
Local ready
Direct docking supported
|
|
E3L066901
LIG001471
|
PK-1016
O=C1CCC(N2C(=O)c3cc(F)c(N4CCOCC4)cc3C2=O)C(=O)N1
|
C17H16FN3O5 361.329000 |
TYIBGDNEWVDXEE-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB953
|
Local ready
Direct docking supported
|
|
E3L066903
LIG001473
|
Z5112160255
Cn1nc(C2CCC(=O)NC2=O)c2ccc(NC(=O)NC3C=CCC3)cc21
|
C19H21N5O3 367.409000 |
TYJRSIYOSOMZQL-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB585
|
Local ready
Direct docking supported
|
|
E3L066904
LIG001474
|
21
CC[C@H](CO)Nc1nc(NCc2ccc(C3=CCOCC3)cc2)c2ncn(C(C)C)c2n1
|
C24H32N6O2 436.560000 |
TYKLAHYFUUURJU-HXUWFJFHSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB211
|
Local ready
Direct docking supported
|
|
E3L066905
LIG001475
|
UOM-005606
O=C(Cc1ccc(N2CCOCC2)cc1)Nc1ncc(SCc2cccnc2)s1
|
C21H22N4O2S2 426.567000 |
TZJJNGMCPZJCII-UHFFFAOYSA-N | - | - |
MolGlueDB
MolGlueDB:MGDB1490
|
Local ready
Direct docking supported
|