| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L013181
BDB013181
|
US9580437, Example 180
Cc1c(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)ccnc1F
|
C20H16F2N6O 394.385000 |
HDRWZYVTIMPROL-UHFFFAOYSA-N | O75530 | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED |
BindingDB, PubChem
BindingDB:BDBM291865; PubChem:CID121433014
|
Local ready
Direct docking supported
|
|
E3L013182
BDB013182
|
US9580437, Example 181
Cc1c(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)ccnc1C(F)F
|
C21H17F3N6O 426.402000 |
PEPPYKUBKDTDCC-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291866; PubChem:CID121432882
|
Local ready
Direct docking supported
|
|
E3L013183
BDB013183
|
US9580437, Example 182
Cc1c(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)ccnc1CF
|
C21H18F2N6O 408.412000 |
SOHBSLPUHGZIPL-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291867; PubChem:CID121433087
|
Local ready
Direct docking supported
|
|
E3L013184
BDB013184
|
US9580437, Example 183
Cc1cnc(F)cc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C20H16F2N6O 394.385000 |
QQOBZPFXQOLKKN-UHFFFAOYSA-N | O75530 | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED |
BindingDB, PubChem
BindingDB:BDBM291868; PubChem:CID121432983
|
Local ready
Direct docking supported
|
|
E3L013185
BDB013185
|
US9580437, Example 184
Cc1cnc(C(F)(F)F)cc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C21H16F4N6O 444.392000 |
GGUAEXUHPRZDCO-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291869; PubChem:CID121432888
|
Local ready
Direct docking supported
|
|
E3L013186
BDB013186
|
US9580437, Example 185
Fc1ccc2c(c1CNc1ncc(-c3ccnc(C(F)(F)F)c3)c3nncn13)CCO2
|
C20H14F4N6O 430.365000 |
OWAJZJKXTMXEPC-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291870; PubChem:CID121432984
|
Local ready
Direct docking supported
|
|
E3L013187
BDB013187
|
US9580437, Example 186
Cc1nn(C[C@@H](C)O)c(C)c1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C22H24FN7O2 437.479000 |
PZMYACQKVABGEK-GFCCVEGCSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291871; PubChem:CID126626242
|
Local ready
Direct docking supported
|
|
E3L013188
BDB013188
|
US9580437, Example 187
Cc1nn(C[C@H](C)O)c(C)c1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C22H24FN7O2 437.479000 |
PZMYACQKVABGEK-LBPRGKRZSA-N | O75530 | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED |
BindingDB, PubChem
BindingDB:BDBM291872; PubChem:CID126626160
|
Local ready
Direct docking supported
|
|
E3L013189
BDB013189
|
US9580437, Example 188
Cc1c(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)cnn1C(C)C
|
C21H22FN7O 407.453000 |
SFYRATFDIVLMCE-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291873; PubChem:CID121433089
|
Local ready
Direct docking supported
|
|
E3L013190
BDB013190
|
US9580437, Example 189
Cc1c(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)cnn1CCO
|
C20H20FN7O2 409.425000 |
CFZVHLDMRCTMQP-UHFFFAOYSA-N | O75530 | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED |
BindingDB, PubChem
BindingDB:BDBM291874; PubChem:CID121432889
|
Local ready
Direct docking supported
|
|
E3L013191
BDB013191
|
US9580437, Example 190
Cc1nn(CCO)cc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C20H20FN7O2 409.425000 |
YJGGHCUWIOSYKC-UHFFFAOYSA-N | O75530 | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED |
BindingDB, PubChem
BindingDB:BDBM291875; PubChem:CID121432894
|
Local ready
Direct docking supported
|
|
E3L013192
BDB013192
|
US9580437, Example 191
Fc1ccc2c(c1CNc1ncc(-c3cncnc3C(F)F)c3nncn13)CCO2
|
C19H14F3N7O 413.363000 |
CFFRRKGGZFEJCN-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291876; PubChem:CID121432893
|
Local ready
Direct docking supported
|
|
E3L013193
BDB013193
|
US9580437, Example 192
Fc1ccc2c(c1CNc1ncc(-c3ccnn3C3CC3)c3nncn13)CCO2
|
C20H18FN7O 391.410000 |
DRICLSBQZNGRNU-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291877; PubChem:CID121432895
|
Local ready
Direct docking supported
|
|
E3L013194
BDB013194
|
US9580437, Example 193
FCc1ncccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C20H16F2N6O 394.385000 |
BFNBFIAGUDLBGV-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291878; PubChem:CID121432910
|
Local ready
Direct docking supported
|
|
E3L013195
BDB013195
|
US9580437, Example 194
Cc1cc(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)c(C)cn1
|
C21H19FN6O 390.422000 |
DMWNOBLGMPUHMK-UHFFFAOYSA-N | O75530 | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED |
BindingDB, PubChem
BindingDB:BDBM291879; PubChem:CID121432913
|
Local ready
Direct docking supported
|
|
E3L013196
BDB013196
|
US9580437, Example 195
Cc1nn(C)cc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C19H18FN7O 379.399000 |
HIOYDIJURIUQHD-UHFFFAOYSA-N | O75530 | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED |
BindingDB, PubChem
BindingDB:BDBM291880; PubChem:CID121432912
|
Local ready
Direct docking supported
|
|
E3L013197
BDB013197
|
US9580437, Example 196
CCOc1cc(C)c(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cnnc23)cn1
|
C22H21FN6O2 420.448000 |
PYGKIPLIGFESER-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291881; PubChem:CID121432989
|
Local ready
Direct docking supported
|
|
E3L013198
BDB013198
|
US9580437, Example 197
Cc1cc(OC(F)F)ncc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C21H17F3N6O2 442.401000 |
FCAXPENQAZDWCQ-UHFFFAOYSA-N | O75530 | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM291882; PubChem:CID121433010
|
Local ready
Direct docking supported
|
|
E3L013199
BDB013199
|
US9580437, Example 198
Cc1cnc(C(F)F)cc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C21H17F3N6O 426.402000 |
HYRXVAVQIHXVFZ-UHFFFAOYSA-N | O75530 | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED |
BindingDB, PubChem
BindingDB:BDBM291883; PubChem:CID121432911
|
Local ready
Direct docking supported
|
|
E3L013200
BDB013200
|
US9580437, Example 199
Cc1nc(C(=O)N(C)C)ccc1-c1cnc(NCc2c(F)ccc3c2CCO3)n2cnnc12
|
C23H22FN7O2 447.474000 |
DMOUAYZQHPZOBL-UHFFFAOYSA-N | O75530 | Histone-lysine N-methyltransferase EZH2, Polycomb protein EED |
BindingDB, PubChem
BindingDB:BDBM291884; PubChem:CID121432992
|
Local ready
Direct docking supported
|