E3 Ligase Ligand Database

MGD and E3 ligand related compounds for browsing and docking.
Reset
Structure similarity search Input SMILES or upload SDF/MOL/MOL2/PDB/PDBQT; results use Morgan fingerprint Tanimoto.
67228 compounds match the current filters. 123739 source records are linked to them.
Compound ID Name Formula / MW InChIKey E3 Target Source Docking structure
E3L065141
BDB065141
 BDBM50646903
C/C=C(\C)C(=O)OC[C@@]12C(=O)C[C@@H](C)[C@](C)(CCC3=CC(=O)OC3)[C@H]1CCC[C@]21CO1
 C25H34O6
430.541000		 LFFWHLULURLEEC-SWMUMAEJSA-N P37231 Peroxisome proliferator-activated receptor gamma
BindingDB
BindingDB:BDBM50646903
 Local ready
Direct docking supported
E3L065142
BDB065142
 BDBM50646904
C/C=C(\C)C(=O)OC[C@]12[C@H]3CCC[C@@]1(O)CO[C@@]2(O)C[C@H](C)[C@@]3(C)CCC1=CC(=O)OC1
 C25H36O7
448.556000		 FTDJWBWGTLXWTI-WIZXHRKDSA-N P37231 Peroxisome proliferator-activated receptor gamma
BindingDB, PubChem
BindingDB:BDBM50646904; PubChem:CID177378227
 Local ready
Direct docking supported
E3L065143
BDB065143
 BDBM50646905
C/C=C(\C)C(=O)O[C@@H]1CC[C@](O)(CCl)[C@]2(COC(C)=O)[C@@H](OC(C)=O)C[C@@H](C)[C@](C)(C/C=C(/C=O)CC(=O)OC)[C@@H]12
 C30H43ClO10
599.117000		 KGBBGLXVIZMHMA-BPZDGVASSA-N P37231 Peroxisome proliferator-activated receptor gamma
BindingDB
BindingDB:BDBM50646905
 Local ready
Direct docking supported
E3L065144
BDB065144
 BDBM50646906
C/C=C(\C)C(=O)O[C@@H]1CC[C@]2(CO2)[C@]2(COC(C)=O)[C@@H](OC(C)=O)C[C@@H](C)[C@](C)(CC(=O)C3=CC(=O)OC3)[C@@H]12
 C29H38O10
546.613000		 KLWARXRPLNVYSQ-GLTAQTHJSA-N P37231 Peroxisome proliferator-activated receptor gamma
BindingDB
BindingDB:BDBM50646906
 Local ready
Direct docking supported
E3L065145
BDB065145
 BDBM50646907
C[C@@H]1C[C@H](O)[C@@]2(COC(=O)c3ccc(N(C)C)cc3)C(=O)CCC[C@@H]2[C@@]1(C)CCC1=CC(=O)OC1
 C28H37NO6
483.605000		 HUMWEFKVZLKCEV-DOSULMPCSA-N P37231 Peroxisome proliferator-activated receptor gamma
BindingDB, PubChem
BindingDB:BDBM50646907; PubChem:CID177378230
 Local ready
Direct docking supported
E3L065146
BDB065146
 BDBM50646908
CC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O)C(C)C)[C@H](C)O
 C92H134N22O28
1996.210000		 ZJPXXOSHDRFGCQ-WIGGVEJCSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646908; PubChem:CID177378231
 Local ready
Direct docking supported
E3L065147
BDB065147
 BDBM50646909
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O)C(C)C)[C@@H](C)O)[C@@H](C)O
 C95H138N24O28
2064.289000		 CDEVDINBEWURLD-RDDNVDJKSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646909; PubChem:CID177378232
 Local ready
Direct docking supported
E3L065148
BDB065148
 BDBM50646910
CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O)C(C)C)[C@@H](C)O
 C97H143N27O26S2
2167.508000		 ASKCKRFHUAEXBU-FSUDMPOFSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646910; PubChem:CID177378233
 Local ready
Direct docking supported
E3L065149
BDB065149
 BDBM50646911
CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)O)C(C)C
 C92H141N21O29
2005.258000		 GMGKKPRMYZCIAI-RUZGEFBHSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646911; PubChem:CID177378234
 Local ready
Direct docking supported
E3L065150
BDB065150
 BDBM50646912
CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(N)=O)[C@@H](C)O
 C80H123N17O22
1674.961000		 XOUNIVNYMPUOAY-HXIUBCSDSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646912; PubChem:CID177378235
 Local ready
Direct docking supported
E3L065151
BDB065151
 BDBM50646913
CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(N)=O)[C@@H](C)O
 C79H119N17O24
1690.916000		 WCBVVSINIVEUCO-FBRDICCOSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646913; PubChem:CID177378236
 Local ready
Direct docking supported
E3L065152
BDB065152
 BDBM50646914
CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(N)=O)[C@@H](C)O
 C80H124N20O21
1701.991000		 HWEKBIYYUDHBTL-FWJNDSIBSA-N O15151, Q00987 E3 ubiquitin-protein ligase Mdm2, Protein Mdm4
BindingDB, PubChem
BindingDB:BDBM50646914; PubChem:CID177378237
 Local ready
Direct docking supported
E3L065153
BDB065153
 BDBM50646915
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC#N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(N)=O)[C@@H](C)O
 C80H114N18O21
1663.897000		 FQUDKMBHLWDJCH-BDEQMLCRSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646915; PubChem:CID177378238
 Local ready
Direct docking supported
E3L065154
BDB065154
 BDBM50646916
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(N)=O)[C@@H](C)O
 C90H134N20O23
1864.179000		 QLGXNCRRTGQWPN-MLBDVJTGSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646916; PubChem:CID177378239
 Local ready
Direct docking supported
E3L065155
BDB065155
 BDBM50646917
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(N)=O)[C@@H](C)O
 C81H119N17O20
1650.942000		 BUUBREMWCSOFJY-IGUCBEICSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646917; PubChem:CID177378240
 Local ready
Direct docking supported
E3L065156
BDB065156
 BDBM50646918
CN(C)C1CCN(C(=O)CCC(=O)C(c2ccc(Cl)cc2)C(C(=O)c2ccc(Cl)cc2)c2ccc(F)cc2Cl)CC1
 C32H32Cl3FN2O3
617.976000		 MVSCLPPKLQIMRO-UHFFFAOYSA-N O15151, Q00987 E3 ubiquitin-protein ligase Mdm2, Protein Mdm4
BindingDB, PubChem
BindingDB:BDBM50646918; PubChem:CID177378241
 Local ready
Direct docking supported
E3L065157
BDB065157
 BDBM50646919
O=C(CCC(=O)N1CCNCC1)C(c1ccc(Cl)cc1)C(C(=O)c1ccc(Cl)cc1)c1ccc(F)cc1Cl
 C29H26Cl3FN2O3
575.895000		 IWVXRMNLZOPZCL-UHFFFAOYSA-N O15151, Q00987 E3 ubiquitin-protein ligase Mdm2, Protein Mdm4
BindingDB, PubChem
BindingDB:BDBM50646919; PubChem:CID177378242
 Local ready
Direct docking supported
E3L065158
BDB065158
 BDBM50646920
O=C1CN(C(=O)N2C(c3ccc4c(c3)NC(=O)CNC4=O)=N[C@@H](c3ccc(Cl)cc3)[C@H]2c2ccc(Cl)cc2)CCN1
 C29H24Cl2N6O4
591.455000		 RBPMTSWCNAXIST-IZZNHLLZSA-N O15151, Q00987 Protein Mdm4, E3 ubiquitin-protein ligase Mdm2
BindingDB, PubChem
BindingDB:BDBM50646920; PubChem:CID177378243
 Local ready
Direct docking supported
E3L065159
BDB065159
 BDBM50646921
O=C1CN(C(=O)N2C(c3ccc4c(c3)N(c3ccccc3)C(=O)CNC4=O)=N[C@@H](c3ccc(Cl)cc3)[C@H]2c2ccc(Cl)cc2)CCN1
 C35H28Cl2N6O4
667.553000		 PENAOFSOABMOLO-AJQTZOPKSA-N O15151, Q00987 E3 ubiquitin-protein ligase Mdm2, Protein Mdm4
BindingDB, PubChem
BindingDB:BDBM50646921; PubChem:CID177378244
 Local ready
Direct docking supported
E3L065160
BDB065160
 BDBM50646922
CC(C)Oc1cc(N)ccc1C1=N[C@@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N1C(=O)N1CCNC(=O)C1
 C29H29Cl2N5O3
566.489000		 MPTNLLAKODQHMZ-RRPNLBNLSA-N O15151 Protein Mdm4
BindingDB, PubChem
BindingDB:BDBM50646922; PubChem:CID177378245
 Local ready
Direct docking supported