| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L065161
BDB065161
|
BDBM50646923
COc1ccc(C2=N[C@@H](c3cc(Br)ccc3F)[C@@H](c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1
|
C30H29BrClFN4O4 643.941000 |
HYPWYUYQMBEAQR-WUFINQPMSA-N | O15151 | Protein Mdm4 |
BindingDB, PubChem
BindingDB:BDBM50646923; PubChem:CID122606275
|
Local ready
Direct docking supported
|
|
E3L065162
BDB065162
|
BDBM50646924
CCOC(=O)C1=NN(C2CCCCC2)[C@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C25H24Cl2FN3O3 504.389000 |
MQTQJFOZONMLPL-CPJSRVTESA-N | O15151, Q00987 | Protein Mdm4, E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM50646924; PubChem:CID177378246
|
Local ready
Direct docking supported
|
|
E3L065163
BDB065163
|
BDBM50646925
CCOC(=O)C1=NN(c2ccc(Cl)cc2)[C@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C25H17Cl3FN3O3 532.786000 |
HIUSVJZXJUTUQG-CPJSRVTESA-N | O15151, Q00987 | E3 ubiquitin-protein ligase Mdm2, Protein Mdm4 |
BindingDB, PubChem
BindingDB:BDBM50646925; PubChem:CID170902608
|
Local ready
Direct docking supported
|
|
E3L065164
BDB065164
|
BDBM50646926
O=C(Nc1cccc(-n2ccc(-c3ccccc3)n2)c1)C1=NN(c2ccc(Cl)cc2)[C@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(O)c1
|
C38H26Cl2N6O3 685.571000 |
MMVJKWGROZJXQD-UVNLRBHVSA-N | O15151, Q00987 | Protein Mdm4, E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM50646926; PubChem:CID170903112
|
Local ready
Direct docking supported
|
|
E3L065165
BDB065165
|
BDBM50646927
O=C(Nc1cccc(-n2cccn2)c1)C1=NN(c2ccc(Cl)cc2)[C@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(O)c1
|
C32H22Cl2N6O3 609.473000 |
KZVNWGAQQJSTDL-IUDBTDONSA-N | O15151, Q00987 | E3 ubiquitin-protein ligase Mdm2, Protein Mdm4 |
BindingDB, PubChem
BindingDB:BDBM50646927; PubChem:CID170902641
|
Local ready
Direct docking supported
|
|
E3L065166
BDB065166
|
BDBM50646928
COc1cc(Cc2c(-c3ccccc3)[nH]c3cc(C)ccc23)cc(OC)c1OC
|
C25H25NO3 387.479000 |
PTIKSFBHIDVCFT-UHFFFAOYSA-N | O15151, Q00987 | Protein Mdm4, E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM50646928; PubChem:CID177378247
|
Local ready
Direct docking supported
|
|
E3L065167
BDB065167
|
BDBM50646929
COc1cc(C(O)c2c(-c3cc[nH]c3)[nH]c3ccccc23)cc(OC)c1OC
|
C22H22N2O4 378.428000 |
YIDKQFGMXKRFAQ-UHFFFAOYSA-N | O15151, Q00987 | E3 ubiquitin-protein ligase Mdm2, Protein Mdm4 |
BindingDB, PubChem
BindingDB:BDBM50646929; PubChem:CID53469636
|
Local ready
Direct docking supported
|
|
E3L065168
BDB065168
|
BDBM50646930
COc1cc(Cc2c(-c3ccn(S(=O)(=O)c4ccccc4)c3)[nH]c3ccccc23)cc(OC)c1OC
|
C28H26N2O5S 502.592000 |
KTTHUXOEXYKHFJ-UHFFFAOYSA-N | O15151, Q00987 | Protein Mdm4, E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM50646930; PubChem:CID71546668
|
Local ready
Direct docking supported
|
|
E3L065169
BDB065169
|
BDBM50646931
COc1cccc2c1NCC2C(=O)N[C@H]1CCN(c2ccc(C)cc2)C1
|
C21H25N3O2 351.450000 |
FRPHVMCKSYBPIY-BUSXIPJBSA-N | O15151, Q00987 | E3 ubiquitin-protein ligase Mdm2, Protein Mdm4 |
BindingDB, PubChem
BindingDB:BDBM50646931; PubChem:CID177378248
|
Local ready
Direct docking supported
|
|
E3L065170
BDB065170
|
3,6-Diaminoacridine-9-carbonitrile
N#Cc1c2ccc(N)cc2nc2cc(N)ccc12
|
C14H10N4 234.262000 |
PUMGFEMNXBLDKD-UHFFFAOYSA-N | O15151 | Protein Mdm4 |
BindingDB, PubChem
BindingDB:BDBM50646932; PubChem:CID435038
|
Local ready
Direct docking supported
|
|
E3L065171
BDB065171
|
BDBM50646933
CC(C)C(=O)Nc1ccccc1SC(=O)C(C)C
|
C14H19NO2S 265.378000 |
CBTICXFNIGNHEP-UHFFFAOYSA-N | O15151, Q00987 | E3 ubiquitin-protein ligase Mdm2, Protein Mdm4 |
BindingDB, PubChem
BindingDB:BDBM50646933; PubChem:CID53374865
|
Local ready
Direct docking supported
|
|
E3L065172
BDB065172
|
BDBM50646934
C[C@@H]1C(=O)N(C)[C@@H](C)C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N(C)[C@@H](C)C(=O)N[C@@H](Cc2cscn2)C(=O)N1C
|
C59H75ClFN11O10S 1184.834000 |
INPLDSAPSDBLLW-OXDQBNBYSA-N | O15151 | Protein Mdm4 |
BindingDB, PubChem
BindingDB:BDBM50646934; PubChem:CID177378249
|
Local ready
Direct docking supported
|
|
E3L065173
BDB065173
|
BDBM50646935
CCCCC[C@@H]1NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](C)N(C)C(=O)[C@@H](C)N(C)C(=O)[C@H](Cc2cscn2)NC(=O)[C@H](C)N(C)C(=O)CNC(=O)[C@H]2CCCN2C(=O)[C@H](CC(CC)CC)N(C)C1=O
|
C57H88FN11O10S 1138.463000 |
GIDRLHRXJFUPCX-DCMWNUTASA-N | O15151 | Protein Mdm4 |
BindingDB
BindingDB:BDBM50646935
|
Local ready
Direct docking supported
|
|
E3L065174
BDB065174
|
BDBM50647304
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(N5CCN(CC(=O)N[C@H](C(=O)N6C[C@H](O)C[C@H]6C(=O)NCc6ccc(-c7scnc7C)cc6)C(C)(C)C)CC5)cc4)cc23)c1F
|
C51H57F2N9O7S2 1010.203000 |
MBCAVOCJJAQHHT-FGUOTCRGSA-N | Q15369 | Elongin-C |
BindingDB
BindingDB:BDBM50647304
|
Local ready
Direct docking supported
|
|
E3L065175
BDB065175
|
BDBM50647316
CN(C)C(=O)c1cc2cnc(Nc3ccc(S(=O)(=O)N(C)C)cc3Cl)cc2[nH]1
|
C18H20ClN5O3S 421.910000 |
WWAPUHXVVWFCFW-UHFFFAOYSA-N | O14965 | Aurora kinase A |
BindingDB, PubChem
BindingDB:BDBM50647316; PubChem:CID177378552
|
Local ready
Direct docking supported
|
|
E3L065176
BDB065176
|
BDBM50647317
CN(C)C(=O)c1cc2cnc(Nc3ccc(-c4cnn(C)c4)cc3Cl)cc2[nH]1
|
C20H19ClN6O 394.866000 |
SMYIRTWZKCFRRG-UHFFFAOYSA-N | O14965 | Aurora kinase A |
BindingDB, PubChem
BindingDB:BDBM50647317; PubChem:CID177378553
|
Local ready
Direct docking supported
|
|
E3L065177
BDB065177
|
BDBM50647318
COC1CCN(C(=O)c2ccc(Nc3cc4[nH]c(C(=O)N(C)C)cc4cn3)c(Cl)c2)CC1
|
C23H26ClN5O3 455.946000 |
VXHHRUITLRQZFT-UHFFFAOYSA-N | O14965 | Aurora kinase A |
BindingDB, PubChem
BindingDB:BDBM50647318; PubChem:CID177378554
|
Local ready
Direct docking supported
|
|
E3L065178
BDB065178
|
BDBM50647319
CN(C)C(=O)c1ccc(Nc2cc3c(cn2)cc(C(=O)N(C)C)n3C(=O)OC(C)(C)C)c(Cl)c1
|
C24H28ClN5O4 485.972000 |
FSBZLMWCSXRVNQ-UHFFFAOYSA-N | O14965 | Aurora kinase A |
BindingDB, PubChem
BindingDB:BDBM50647319; PubChem:CID177378555
|
Local ready
Direct docking supported
|
|
E3L065179
BDB065179
|
BDBM50647320
CN(C)C(=O)c1cc2cnc(Nc3ccc(-c4cncn4C)cc3Cl)cc2n1C(=O)OC(C)(C)C
|
C25H27ClN6O3 494.983000 |
YZUYAPCPGAAOJF-UHFFFAOYSA-N | O14965 | Aurora kinase A |
BindingDB, PubChem
BindingDB:BDBM50647320; PubChem:CID177378556
|
Local ready
Direct docking supported
|
|
E3L065180
BDB065180
|
BDBM50647543
CNc1nc(Nc2ccc(C(=O)N3CCN(C[C@H]4CC[C@H](CSC(C)(C)[C@H](NC(=O)C5(F)CC5)C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)CC4)CC3)cc2OC)ncc1Cl
|
C50H64ClFN10O6S2 1019.711000 |
HKSBXNVKPFTBIG-SHFRUIRLSA-N | Q15369 | Elongin-C |
BindingDB
BindingDB:BDBM50647543
|
Local ready
Direct docking supported
|