| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L026781
BDB026781
|
US11407721, Example 69
Cc1nnc([C@@H](C2CC2)N2C(=O)[C@@H](CC(=O)O)O[C@H](c3cccc(Cl)c3)[C@@H]2c2ccc(Cl)cc2)o1
|
C25H23Cl2N3O5 516.381000 |
GWQMSXSOODJZMZ-CWKRKGSWSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562822; PubChem:CID90372142
|
Local ready
Direct docking supported
|
|
E3L026782
BDB026782
|
US11407721, Example 70
N#Cc1ccc(C[C@@H]2O[C@@H](c3cccc(Cl)c3)[C@@H](c3ccc(Cl)cc3)N([C@H](C(=O)O)C3CC3)C2=O)cc1
|
C29H24Cl2N2O4 535.427000 |
XTXXVBJFTBMVSK-XUJYPJAKSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562823; PubChem:CID165414773
|
Local ready
Direct docking supported
|
|
E3L026783
BDB026783
|
US11407721, Example 71
N#Cc1ccc(C[C@H]2O[C@H](c3ccc(Cl)cc3)[C@H](c3ccc(Cl)cc3)N([C@H](C(=O)O)C3CC3)C2=O)cc1
|
C29H24Cl2N2O4 535.427000 |
MURGPOPKNPYXAX-LGTXBLIGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562824; PubChem:CID118622823
|
Local ready
Direct docking supported
|
|
E3L026784
BDB026784
|
US11407721, Example 72
O=C1CS[C@@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)C1CC1CC1
|
C21H20Cl2OS 391.363000 |
ZGKYOMGTRZWPLK-LLQWEQGGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562825; PubChem:CID145748338
|
Local ready
Direct docking supported
|
|
E3L026785
BDB026785
|
US11407721, Example 73
CC1(C)C(=O)N(CC2CC2)[C@H](c2ccc(Cl)cc2)[C@H](c2cccc(Cl)c2)S1(=O)=O
|
C22H23Cl2NO3S 452.403000 |
HVHAGGDWFLSMMK-UXHICEINSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562826; PubChem:CID90371790
|
Local ready
Direct docking supported
|
|
E3L026786
BDB026786
|
US11407721, Example 74
CC(C)N1C(=O)CS[C@@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1
|
C19H19Cl2NOS 380.340000 |
VKUFOQXIICORFX-MOPGFXCFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562827; PubChem:CID90371965
|
Local ready
Direct docking supported
|
|
E3L026787
BDB026787
|
US11407721, Example 75
CC(C)N1C(=O)[C@H](CC(=O)O)S(=O)(=O)[C@@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1
|
C21H21Cl2NO5S 470.374000 |
ISMHSIODMKAFIJ-SXLOBPIMSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562828; PubChem:CID90372191
|
Local ready
Direct docking supported
|
|
E3L026788
BDB026788
|
US11407721, Example 76
CC(C)N1C(=O)[C@H]2CCC(=O)N2[C@@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1
|
C22H22Cl2N2O2 417.336000 |
VFQSDHHWNIJHMY-NRSPTQNISA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562829; PubChem:CID90371978
|
Local ready
Direct docking supported
|
|
E3L026789
BDB026789
|
US11407721, Example 77
CC(C)N1C(=O)[C@@H]2CCC(=O)N2[C@@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1
|
C22H22Cl2N2O2 417.336000 |
VFQSDHHWNIJHMY-TYPHKJRUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562830; PubChem:CID90371776
|
Local ready
Direct docking supported
|
|
E3L026790
BDB026790
|
US11407721, Example 78
CC[C@@H](CO)N1C(=O)[C@@H](CC(=O)O)O[C@@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1
|
C22H23Cl2NO5 452.334000 |
GOJFTLJDUNFYCJ-ZSXPUABSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562831; PubChem:CID90371760
|
Local ready
Direct docking supported
|
|
E3L026791
BDB026791
|
BDBM562833
O=C1N[C@H](c2ccc(Cl)cc2)[C@H](c2ccc(Cl)cc2)O[C@H]1Cc1ccc(F)cc1
|
C23H18Cl2FNO2 430.306000 |
NNHHVXDUFOZJBY-BDTNDASRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562833; PubChem:CID90372005
|
Local ready
Direct docking supported
|
|
E3L026792
BDB026792
|
US11407721, Example 81
O=C1N[C@@H](c2ccc(Cl)cc2)[C@@H](c2ccc(Cl)cc2)O[C@@H]1Cc1ccc(F)cc1
|
C23H18Cl2FNO2 430.306000 |
NNHHVXDUFOZJBY-BHIFYINESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562834; PubChem:CID90372001
|
Local ready
Direct docking supported
|
|
E3L026793
BDB026793
|
BDBM562835
C[C@@]1(c2ccc(Cl)cc2)[C@H](c2cccc(Cl)c2)O[C@@H](CC(=O)O)C(=O)N1CC1CC1
|
C23H23Cl2NO4 448.346000 |
KSWKEATWRRWERE-IEIRFRATSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562835; PubChem:CID90371786
|
Local ready
Direct docking supported
|
|
E3L026794
BDB026794
|
US11414384, Example 1 Isomer 1
NS(=O)(=O)c1ccc(CCN[C@H](C(=O)c2c[nH]c3cc(C(F)(F)F)ccc23)c2ccccc2)cc1
|
C25H22F3N3O3S 501.530000 |
YVQSCOZVIVXUQN-QHCPKHFHSA-N | Q09472 | Histone acetyltransferase p300 |
BindingDB, PubChem
BindingDB:BDBM563686; PubChem:CID139422781
|
Local ready
Direct docking supported
|
|
E3L026795
BDB026795
|
US11414384, Example 1 Isomer 2
NS(=O)(=O)c1ccc(CCN[C@@H](C(=O)c2c[nH]c3cc(C(F)(F)F)ccc23)c2ccccc2)cc1
|
C25H22F3N3O3S 501.530000 |
YVQSCOZVIVXUQN-HSZRJFAPSA-N | Q09472 | Histone acetyltransferase p300 |
BindingDB, PubChem
BindingDB:BDBM563688; PubChem:CID156114904
|
Local ready
Direct docking supported
|
|
E3L026796
BDB026796
|
US11414384, Example 2 Isomer 1
O=C(c1c[nH]c2ccccc12)[C@@H](NCCc1ccccc1)c1ccccc1
|
C24H22N2O 354.453000 |
ACAMGSSSBUKFLV-QHCPKHFHSA-N | Q09472 | Histone acetyltransferase p300 |
BindingDB, PubChem
BindingDB:BDBM563690; PubChem:CID139422896
|
Local ready
Direct docking supported
|
|
E3L026797
BDB026797
|
US11414384, Example 2 Isomer 2
O=C(c1c[nH]c2ccccc12)[C@H](NCCc1ccccc1)c1ccccc1
|
C24H22N2O 354.453000 |
ACAMGSSSBUKFLV-HSZRJFAPSA-N | Q09472 | Histone acetyltransferase p300 |
BindingDB, PubChem
BindingDB:BDBM563691; PubChem:CID156114892
|
Local ready
Direct docking supported
|
|
E3L026798
BDB026798
|
US11414384, Example 3 Isomer 1
O=C(c1c[nH]c2ccccc12)[C@@H](NCCc1ccccc1Cl)c1ccccc1
|
C24H21ClN2O 388.898000 |
FNBRBLNOIFPEFQ-QHCPKHFHSA-N | Q09472 | Histone acetyltransferase p300 |
BindingDB, PubChem
BindingDB:BDBM563692; PubChem:CID139422898
|
Local ready
Direct docking supported
|
|
E3L026799
BDB026799
|
US11414384, Example 3 Isomer 2
O=C(c1c[nH]c2ccccc12)[C@H](NCCc1ccccc1Cl)c1ccccc1
|
C24H21ClN2O 388.898000 |
FNBRBLNOIFPEFQ-HSZRJFAPSA-N | Q09472 | Histone acetyltransferase p300 |
BindingDB, PubChem
BindingDB:BDBM563693; PubChem:CID156114885
|
Local ready
Direct docking supported
|
|
E3L026800
BDB026800
|
US11414384, Example 4 Isomer 1
O=C(c1c[nH]c2ccccc12)[C@@H](NCCc1cccc(Cl)c1)c1ccccc1
|
C24H21ClN2O 388.898000 |
VEGMRJOSIJOMAE-QHCPKHFHSA-N | Q09472 | Histone acetyltransferase p300 |
BindingDB, PubChem
BindingDB:BDBM563694; PubChem:CID139422889
|
Local ready
Direct docking supported
|