| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L026721
BDB026721
|
US11401256, Example C
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNC(=O)c1ccc3c(c1)nc(-c1cc(-c4cncn4C)nc4ccccc14)n3-c1ccc3c(c1)CCC(=O)N3)c1nnc(C)n1-2
|
C55H51ClN12O5S 1027.612000 |
VPBHMKNTJMSXMN-GWHBCOKCSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM562173; PubChem:CID137532066
|
Local ready
Direct docking supported
|
|
E3L026722
BDB026722
|
US11407721, Example 4
CN1C(=O)[C@@H](Cc2ccccc2)O[C@H](c2ccc(Cl)cc2)[C@@H]1c1ccc(Cl)cc1
|
C24H21Cl2NO2 426.343000 |
NFFXQTHZDQEVMP-XPWALMASSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562757; PubChem:CID86280982
|
Local ready
Direct docking supported
|
|
E3L026723
BDB026723
|
US11407721, Example 5
CN1C(=O)[C@@H](Cc2ccc(Br)cc2)O[C@H](c2ccc(Br)cc2)[C@@H]1c1ccc(Br)cc1
|
C24H20Br3NO2 594.141000 |
RHWGELPEQKFUHE-XPWALMASSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562758; PubChem:CID86280983
|
Local ready
Direct docking supported
|
|
E3L026724
BDB026724
|
US11407721, Example 6
CN1C(=O)[C@@H](Cc2ccc(F)cc2)O[C@H](c2ccc(Br)cc2)[C@@H]1c1ccc(Br)cc1
|
C24H20Br2FNO2 533.235000 |
ZOPUXVMFTFLAOX-XPWALMASSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562759; PubChem:CID86281117
|
Local ready
Direct docking supported
|
|
E3L026725
BDB026725
|
US11407721, Example 7
COc1ccc(C[C@H]2O[C@H](c3ccc(Br)cc3)[C@H](c3ccc(Br)cc3)N(C)C2=O)cc1
|
C25H23Br2NO3 545.271000 |
JQFPMGMYKYPPLI-TZRRMPRUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562760; PubChem:CID86281118
|
Local ready
Direct docking supported
|
|
E3L026726
BDB026726
|
US11407721, Example 8
CN1C(=O)[C@@H](Cc2ccc(OC(F)(F)F)cc2)O[C@H](c2ccc(Br)cc2)[C@@H]1c1ccc(Br)cc1
|
C25H20Br2F3NO3 599.241000 |
HYNGBJAFVPKRRJ-XPWALMASSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562761; PubChem:CID86281252
|
Local ready
Direct docking supported
|
|
E3L026727
BDB026727
|
US11407721, Example 9
COc1cccc(C[C@H]2O[C@H](c3ccc(Br)cc3)[C@H](c3ccc(Br)cc3)N(C)C2=O)c1
|
C25H23Br2NO3 545.271000 |
FCOPQZKTHYVUEK-TZRRMPRUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562762; PubChem:CID86281253
|
Local ready
Direct docking supported
|
|
E3L026728
BDB026728
|
US11407721, Example 11
CN1C(=O)COC(c2cccc(Cl)c2)[C@@H]1c1ccc(Cl)cc1
|
C17H15Cl2NO2 336.218000 |
ZUYDNBDMQAEZPD-BHWOMJMDSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562764; PubChem:CID90372038
|
Local ready
Direct docking supported
|
|
E3L026729
BDB026729
|
US11407721, Example 12
O=C1CO[C@H](c2cccc(Cl)c2)[C@H](c2ccc(Cl)cc2)N1CC1CC1
|
C20H19Cl2NO2 376.283000 |
USNQYGDSTBFBSK-VQTJNVASSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562765; PubChem:CID86281255
|
Local ready
Direct docking supported
|
|
E3L026730
BDB026730
|
US11407721, Example 13
CN1C(=O)[C@@H](Cc2ccccc2)O[C@H](c2cccc(Cl)c2)[C@@H]1c1ccc(Cl)cc1
|
C24H21Cl2NO2 426.343000 |
FFWXYSDZASUBHP-XPWALMASSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562766; PubChem:CID86281385
|
Local ready
Direct docking supported
|
|
E3L026731
BDB026731
|
US11407721, Example 14 Step B
O=C1[C@H](C[C@@H](O)CO)O[C@@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N1CC1CC1
|
C23H25Cl2NO4 450.362000 |
UXPNGKJMGNJWPS-MBDNFAEBSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562768; PubChem:CID86281387
|
Local ready
Direct docking supported
|
|
E3L026732
BDB026732
|
US11407721, Example 15
O=CC[C@H]1O[C@H](c2cccc(Cl)c2)[C@H](c2ccc(Cl)cc2)N(CC2CC2)C1=O
|
C22H21Cl2NO3 418.320000 |
CYSOHQCKGNQBDC-QHAWAJNXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562769; PubChem:CID90371866
|
Local ready
Direct docking supported
|
|
E3L026733
BDB026733
|
US11407721, Example 16
O=C1[C@@H](CCO)O[C@H](c2cccc(Cl)c2)[C@H](c2ccc(Cl)cc2)N1CC1CC1
|
C22H23Cl2NO3 420.336000 |
BTFDOQOPNARQSS-QHAWAJNXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562770; PubChem:CID86281514
|
Local ready
Direct docking supported
|
|
E3L026734
BDB026734
|
US11407721, Example 18
CNCC[C@H]1O[C@H](c2cccc(Cl)c2)C(c2ccc(Cl)cc2)N(CC2CC2)C1=O
|
C23H26Cl2N2O2 433.379000 |
FODTWMGUVKCBDV-NHXNGRAPSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562772; PubChem:CID90371740
|
Local ready
Direct docking supported
|
|
E3L026735
BDB026735
|
US11407721, Example 19
O=C1[C@H](CCCO)O[C@@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N1CC1CC1
|
C23H25Cl2NO3 434.363000 |
PMULZUULMROOQM-BDTNDASRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562773; PubChem:CID71661550
|
Local ready
Direct docking supported
|
|
E3L026736
BDB026736
|
US11407721, Example 20
O=C(O)CC[C@H]1O[C@H](c2cccc(Cl)c2)[C@H](c2ccc(Cl)cc2)N(CC2CC2)C1=O
|
C23H23Cl2NO4 448.346000 |
RTDZBLVTLREENZ-BAGYTPMASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562774; PubChem:CID86281638
|
Local ready
Direct docking supported
|
|
E3L026737
BDB026737
|
US11407721, Example 23
O=C(O)C[C@@H]1O[C@@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(CC2CCC2)C1=O
|
C23H23Cl2NO4 448.346000 |
FFLUYTXQAXBHJM-NNWRFLSQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562777; PubChem:CID86281639
|
Local ready
Direct docking supported
|
|
E3L026738
BDB026738
|
US11407721, Example 24
CC(C)CN1C(=O)[C@H](CC(=O)O)O[C@@H](c2cccc(Cl)c2)[C@H]1c1ccc(Cl)cc1
|
C22H23Cl2NO4 436.335000 |
PJRCQJUSRZLUKY-TYPHKJRUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562778; PubChem:CID86281641
|
Local ready
Direct docking supported
|
|
E3L026739
BDB026739
|
US11407721, Example 25
O=C(O)C[C@@H]1O[C@@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(CC2CCCCC2)C1=O
|
C25H27Cl2NO4 476.400000 |
VPRNCQLEQWUMOF-QTJGBDASSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562779; PubChem:CID86280987
|
Local ready
Direct docking supported
|
|
E3L026740
BDB026740
|
US11407721, Example 26
O=C(O)C[C@@H]1O[C@@H](c2cccc(Cl)c2)[C@@H](c2ccc(Cl)cc2)N(Cc2ccccc2)C1=O
|
C25H21Cl2NO4 470.352000 |
FWZPXOOPTXRDSU-QTJGBDASSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM562780; PubChem:CID86281778
|
Local ready
Direct docking supported
|