| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L035181
BDB035181
|
US20240409538, Example 37
COc1ncnc(C2CC2)c1-c1nc2cccc(Cc3ccc(-c4nc(C(F)(F)F)cn4C4CC4)cc3)n2n1
|
C28H24F3N7O 531.542000 |
DMRPWLKYYVBJHM-UHFFFAOYSA-N | Q8TAF3 | Ubiquitin carboxyl-terminal hydrolase 1 |
BindingDB, PubChem
BindingDB:BDBM707433; PubChem:CID171782549
|
Local ready
Direct docking supported
|
|
E3L035182
BDB035182
|
US20240409538, Example 38
COc1ncnc(C2CC2)c1-c1nc2cccc(Cc3ccc(-c4nc(C(F)(F)F)cn4C)c(F)c3)n2n1
|
C26H21F4N7O 523.494000 |
ZRFOGKGKYXYIFB-UHFFFAOYSA-N | Q8TAF3 | Ubiquitin carboxyl-terminal hydrolase 1 |
BindingDB, PubChem
BindingDB:BDBM707434; PubChem:CID171782540
|
Local ready
Direct docking supported
|
|
E3L035183
BDB035183
|
US20240409538, Example 39
CCn1cc(C(F)(F)F)nc1-c1c(F)cc(Cc2cccc3nc(-c4c(OC)ncnc4C4CC4)nn23)cc1OC
|
C28H25F4N7O2 567.547000 |
ABCVQYPJWJHXES-UHFFFAOYSA-N | Q8TAF3 | Ubiquitin carboxyl-terminal hydrolase 1 |
BindingDB, PubChem
BindingDB:BDBM707435; PubChem:CID171782541
|
Local ready
Direct docking supported
|
|
E3L035184
BDB035184
|
US20240409538, Example 40
COc1ncnc(C2CC2)c1-c1nc2ccnc(Cc3ccc(-c4nc(C(F)(F)F)cn4C4CC4)cc3)n2n1
|
C27H23F3N8O 532.530000 |
MSCRRWAJDNCFQA-UHFFFAOYSA-N | Q8TAF3 | Ubiquitin carboxyl-terminal hydrolase 1 |
BindingDB, PubChem
BindingDB:BDBM707436; PubChem:CID171782546
|
Local ready
Direct docking supported
|
|
E3L035185
BDB035185
|
US20240409538, Example 41
COc1ncnc(C2CC2)c1-c1nc2ccnc(Cc3ccc(-c4nc(C(F)(F)F)cn4C)c(F)c3)n2n1
|
C25H20F4N8O 524.482000 |
JBSPSTRVVQCBDR-UHFFFAOYSA-N | Q8TAF3 | Ubiquitin carboxyl-terminal hydrolase 1 |
BindingDB, PubChem
BindingDB:BDBM707437; PubChem:CID171782534
|
Local ready
Direct docking supported
|
|
E3L035186
BDB035186
|
US20240409538, Example 42
CCn1cc(C(F)(F)F)nc1-c1c(F)cc(Cc2nccc3nc(-c4c(OC)ncnc4C4CC4)nn23)cc1F
|
C26H21F5N8O 556.499000 |
TXBFKMKAZCMKGU-UHFFFAOYSA-N | Q8TAF3 | Ubiquitin carboxyl-terminal hydrolase 1 |
BindingDB, PubChem
BindingDB:BDBM707438; PubChem:CID171782557
|
Local ready
Direct docking supported
|
|
E3L035187
BDB035187
|
US20240409538, Example 43
COc1ncnc(C2CC2)c1-c1nc2cncc(Cc3ccc(-c4nc(C(F)(F)F)cn4C4CC4)cc3)n2n1
|
C27H23F3N8O 532.530000 |
UGVFUAUPJGYYEW-UHFFFAOYSA-N | Q8TAF3 | Ubiquitin carboxyl-terminal hydrolase 1 |
BindingDB, PubChem
BindingDB:BDBM707439; PubChem:CID171782558
|
Local ready
Direct docking supported
|
|
E3L035188
BDB035188
|
US20240409538, Example 44
COc1ncnc(C2CC2)c1-c1nc2cncc(Cc3ccc(-c4nc(C(F)(F)F)cn4C)c(F)c3)n2n1
|
C25H20F4N8O 524.482000 |
VDJWGMDWYIPSLQ-UHFFFAOYSA-N | Q8TAF3 | Ubiquitin carboxyl-terminal hydrolase 1 |
BindingDB, PubChem
BindingDB:BDBM707440; PubChem:CID171782527
|
Local ready
Direct docking supported
|
|
E3L035189
BDB035189
|
US20240409538, Example 45
CCn1cc(C(F)(F)F)nc1-c1c(F)cc(Cc2cncc3nc(-c4c(OC)ncnc4C4CC4)nn23)cc1F
|
C26H21F5N8O 556.499000 |
ASRKYTPJDUUEKD-UHFFFAOYSA-N | Q8TAF3 | Ubiquitin carboxyl-terminal hydrolase 1 |
BindingDB, PubChem
BindingDB:BDBM707441; PubChem:CID171782539
|
Local ready
Direct docking supported
|
|
E3L035190
BDB035190
|
PROTAC BTK Degrader-10
Cc1cc(-c2cc(Nc3ccc(N4CCN(CCc5ccc(N6CCC(=O)NC6=O)cc5)C[C@@H]4C)cn3)ncn2)ccc1[C@@H](C)NC(=O)c1nc(C(C)(C)C)no1
|
C42H49N11O4 771.927000 |
IFISVDOJTJUTBK-WUFINQPMSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708085; PubChem:CID169081326
|
Local ready
Direct docking supported
|
|
E3L035191
BDB035191
|
US12172992, Example 2
Cc1cc(-c2cc(Nc3ccc(N4CCN(CCc5ccc(N6CCC(=O)NC6=O)cc5)C[C@H]4C)cn3)ncn2)ccc1[C@@H](C)NC(=O)c1nc(C(C)(C)C)no1
|
C42H49N11O4 771.927000 |
IFISVDOJTJUTBK-VSGBNLITSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708086; PubChem:CID169081263
|
Local ready
Direct docking supported
|
|
E3L035192
BDB035192
|
US12172992, Example 3
Cc1cc(-c2cc(Nc3ccc(N4CCN(CCc5ccc(N6CCC(=O)NC6=O)cc5)CC4)cn3)ncn2)ccc1[C@@H](C)NC(=O)c1nc(C(C)(C)C)no1
|
C41H47N11O4 757.900000 |
XTTYHHPEDDXLEH-HHHXNRCGSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708087; PubChem:CID169081264
|
Local ready
Direct docking supported
|
|
E3L035193
BDB035193
|
US12172992, Example 4
Cc1cc(-c2cc(Nc3ccc(N4CCN(CCc5ccc(N6CCC(=O)NC6=O)c(F)c5)C[C@@H]4C)cn3)ncn2)ccc1[C@@H](C)NC(=O)c1nc(C(C)(C)C)no1
|
C42H48FN11O4 789.917000 |
XZWLTIJDAOOAOZ-RRPNLBNLSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708088; PubChem:CID169081285
|
Local ready
Direct docking supported
|
|
E3L035194
BDB035194
|
US12172992, Example 5
Cc1cc(-c2cc(Nc3ccc(N4CCN(CCc5ccc(N6CCC(=O)NC6=O)c(F)c5)C[C@H]4C)cn3)ncn2)ccc1[C@@H](C)NC(=O)c1nc(C(C)(C)C)no1
|
C42H48FN11O4 789.917000 |
XZWLTIJDAOOAOZ-KAYWLYCHSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708089; PubChem:CID169081270
|
Local ready
Direct docking supported
|
|
E3L035195
BDB035195
|
US12172992, Example 6
CC[C@H]1CN(CCc2ccc(N3CCC(=O)NC3=O)cc2)CCN1c1ccc(Nc2cc(-c3ccc([C@@H](C)NC(=O)c4nc(C(C)(C)C)no4)c(C)c3)ncn2)nc1
|
C43H51N11O4 785.954000 |
HJKHARHYGJCYLQ-MVSFAKPFSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708090; PubChem:CID169081318
|
Local ready
Direct docking supported
|
|
E3L035196
BDB035196
|
US12172992, Example 7
CC[C@H]1CN(CCc2ccc(N3CCC(=O)NC3=O)c(F)c2)CCN1c1ccc(Nc2cc(-c3ccc([C@@H](C)NC(=O)c4nc(C(C)(C)C)no4)c(C)c3)ncn2)nc1
|
C43H50FN11O4 803.944000 |
ZXUCGFSMGYJNRI-OFSOJUDTSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708091; PubChem:CID169081340
|
Local ready
Direct docking supported
|
|
E3L035197
BDB035197
|
US12172992, Example 8
CC[C@@H]1CN(CCc2ccc(N3CCC(=O)NC3=O)cc2)CCN1c1ccc(Nc2cc(-c3ccc([C@@H](C)NC(=O)c4nc(C(C)(C)C)no4)c(C)c3)ncn2)nc1
|
C43H51N11O4 785.954000 |
HJKHARHYGJCYLQ-GRKNLSHJSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708092; PubChem:CID169081311
|
Local ready
Direct docking supported
|
|
E3L035198
BDB035198
|
US12172992, Example 9
Cc1cc(-c2cc(Nc3ccc(N4CCN(CCc5ccc(N6CCC(=O)NC6=O)cc5)CC4(C)C)cn3)ncn2)ccc1[C@@H](C)NC(=O)c1nc(C(C)(C)C)no1
|
C43H51N11O4 785.954000 |
FFERLSHFMZMHLG-MUUNZHRXSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708093; PubChem:CID169081338
|
Local ready
Direct docking supported
|
|
E3L035199
BDB035199
|
US12172992, Example 10
Cc1c([C@@H](C)NC(=O)c2nc(C(C)(C)C)no2)ccc(-c2cc(Nc3ccc(N4CCN(CCc5ccc(N6CCC(=O)NC6=O)cc5)C[C@@H]4C)cn3)ncn2)c1F
|
C42H48FN11O4 789.917000 |
HKJLLZRGVOIGSI-AHKZPQOWSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708094; PubChem:CID169081341
|
Local ready
Direct docking supported
|
|
E3L035200
BDB035200
|
US12172992, Example 11
Cc1c([C@@H](C)NC(=O)c2nc(C(C)(C)C)no2)ccc(-c2cc(Nc3ccc(N4CCN(CCc5ccc(N6CCC(=O)NC6=O)cc5)CC4)cn3)ncn2)c1F
|
C41H46FN11O4 775.890000 |
DXAMCKURBGAPRL-AREMUKBSSA-N | Q96SW2 | Protein cereblon |
BindingDB, PubChem
BindingDB:BDBM708095; PubChem:CID169081291
|
Local ready
Direct docking supported
|