| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L036041
BDB036041
|
BDBM723439
C[C@@H]1CN(Cc2cc3c(c(C(F)(F)F)c2)CN(c2cccc(C4(c5nncn5C)CC(F)(F)C4)c2)C3=O)CCC1(F)F
|
C29H28F7N5O 595.563000 |
DFNWJTUIQFBTMS-QGZVFWFLSA-N | Q13191 | E3 ubiquitin-protein ligase CBL-B |
BindingDB, PubChem
BindingDB:BDBM723439; PubChem:CID155435235
|
Local ready
Direct docking supported
|
|
E3L036042
BDB036042
|
BDBM723440
C[C@@H]1CN(Cc2cc3c(c(C(F)(F)F)c2)CN(c2cccc(C4(c5nncn5C)CC(F)(F)C4)c2)C3=O)CCO1
|
C28H28F5N5O2 561.555000 |
PVNFFOKNMXGQRR-QGZVFWFLSA-N | Q13191 | E3 ubiquitin-protein ligase CBL-B |
BindingDB, PubChem
BindingDB:BDBM723440; PubChem:CID155449909
|
Local ready
Direct docking supported
|
|
E3L036043
BDB036043
|
US11091495, Example 32
CN(C)C(=O)c1cc(F)c(-c2cnc(NCc3c(F)ccc4c3CCO4)n3cc(C#N)nc23)cc1F
|
C25H19F3N6O2 492.461000 |
WTANIBLXUWSPSF-UHFFFAOYSA-N | O75530, Q09028 | Histone-lysine N-methyltransferase EZH2 |
BindingDB, PubChem
BindingDB:BDBM725157; PubChem:CID155788080
|
Local ready
Direct docking supported
|
|
E3L036044
BDB036044
|
US20250073340, Example 7
COc1cc(C(N)=O)ccc1NC(=O)[C@]1(C)N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C32H35Cl2FN4O3 613.561000 |
WBJKKMNFNMNHSH-HIUNOHRZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725161; PubChem:CID164591977
|
Local ready
Direct docking supported
|
|
E3L036045
BDB036045
|
US20250073340, Example 8
COc1cc(C(N)=O)ccc1NC(=O)[C@@]1(C)N[C@H](CC(C)(C)C)[C@]2(CNc3cc(Cl)ccc32)[C@@H]1c1cccc(Cl)c1F
|
C32H35Cl2FN4O3 613.561000 |
WBJKKMNFNMNHSH-BSKGKCTDSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725162; PubChem:CID164591798
|
Local ready
Direct docking supported
|
|
E3L036046
BDB036046
|
US20250073340, Example 9
COc1cc(C(N)=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ncc32)[C@H]1c1cccc(Cl)c1F
|
C30H32Cl2FN5O3 600.522000 |
PKLNTJBSCSSFND-SYRFEWCISA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725163; PubChem:CID164591840
|
Local ready
Direct docking supported
|
|
E3L036047
BDB036047
|
US20250073340, Example 10
COc1cc(C(N)=O)ccc1NC(=O)[C@H]1N[C@H](CC(C)(C)C)[C@]2(CNc3cc(Cl)ncc32)[C@@H]1c1cccc(Cl)c1F
|
C30H32Cl2FN5O3 600.522000 |
PKLNTJBSCSSFND-CULBQNCQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725164; PubChem:CID176227881
|
Local ready
Direct docking supported
|
|
E3L036048
BDB036048
|
US20250073340, Example 11
COc1cc(C(N)=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(C(F)(F)F)ncc32)[C@H]1c1cccc(Cl)c1F
|
C31H32ClF4N5O3 634.074000 |
IQIZIUSEZUPIDM-FQFMIMTMSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725165; PubChem:CID164591864
|
Local ready
Direct docking supported
|
|
E3L036049
BDB036049
|
US20250073340, Example 12
COc1cc(C(N)=O)ccc1NC(=O)[C@H]1N[C@H](CC(C)(C)C)[C@]2(CNc3cc(C(F)(F)F)ncc32)[C@@H]1c1cccc(Cl)c1F
|
C31H32ClF4N5O3 634.074000 |
IQIZIUSEZUPIDM-AGSHNOCLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725166; PubChem:CID164591815
|
Local ready
Direct docking supported
|
|
E3L036050
BDB036050
|
US20250073340, Example 14
CC(C)(C)C[C@@H]1N[C@@H](C(=O)N2CCOc3cc(C(N)=O)ccc32)[C@H](c2cccc(Cl)c2F)[C@]12CNc1cc(Cl)ccc12
|
C32H33Cl2FN4O3 611.545000 |
IQUGDBQAOOBUAJ-ULWUHOHFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725167; PubChem:CID164591852
|
Local ready
Direct docking supported
|
|
E3L036051
BDB036051
|
US20250073340, Example 15
CC(C)(C)C[C@H]1N[C@H](C(=O)N2CCOc3cc(C(N)=O)ccc32)[C@@H](c2cccc(Cl)c2F)[C@@]12CNc1cc(Cl)ccc12
|
C32H33Cl2FN4O3 611.545000 |
IQUGDBQAOOBUAJ-LJZFYEOISA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725168; PubChem:CID164591950
|
Local ready
Direct docking supported
|
|
E3L036052
BDB036052
|
US20250073340, Example 16
COc1cc(C(=O)NCCCC#Cc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C49H49Cl2FN6O6 907.871000 |
DNPMZTHJIAHDFY-KBQGJOFZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725169; PubChem:CID164592146
|
Local ready
Direct docking supported
|
|
E3L036053
BDB036053
|
US20250073340, Example 17
COc1cc(C(=O)NCCCC#Cc2cccc3c2CN([C@@H]2CCC(=O)NC2=O)C3=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C49H49Cl2FN6O6 907.871000 |
DNPMZTHJIAHDFY-OKGXSHBPSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725170; PubChem:CID164592141
|
Local ready
Direct docking supported
|
|
E3L036054
BDB036054
|
US20250073340, Example 18
COc1cc(C(=O)NCCCC#Cc2cccc3c2CN([C@H]2CCC(=O)NC2=O)C3=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C49H49Cl2FN6O6 907.871000 |
DNPMZTHJIAHDFY-AMEOJRGXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725171; PubChem:CID164592007
|
Local ready
Direct docking supported
|
|
E3L036055
BDB036055
|
US20250073340, Example 19
COc1cc(C(=O)NCCCC#Cc2cccc3c2CN(C2CCC(=O)N(C)C2=O)C3=O)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C50H51Cl2FN6O6 921.898000 |
UMLJESWHOOXVDD-SQHSVADMSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725172; PubChem:CID164592058
|
Local ready
Direct docking supported
|
|
E3L036056
BDB036056
|
US20250073340, Example 20
COc1cc(C(=O)N2CCC(C#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C51H51Cl2FN6O6 933.909000 |
ZOOZRFOSYFZGBP-JRDHYNAESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725173; PubChem:CID164592071
|
Local ready
Direct docking supported
|
|
E3L036057
BDB036057
|
US20250073340, Example 21
COc1cc(C(=O)NC23CC(C#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)(C2)C3)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C51H49Cl2FN6O6 931.893000 |
HOGCVPJHSJSMKA-MVQOGPFJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725174; PubChem:CID164592054
|
Local ready
Direct docking supported
|
|
E3L036058
BDB036058
|
US20250073340, Example 22
COc1cc(N2CCC3(CC2)CC([C@@H]2C[C@H]2C#Cc2cccc4c2CN(C2CCC(=O)NC2=O)C4=O)C3)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C56H59Cl2FN6O5 986.029000 |
IMHSPCKBQXBAHB-DWMJOQDYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725175; PubChem:CID164591835
|
Local ready
Direct docking supported
|
|
E3L036059
BDB036059
|
US20250073340, Example 23
COc1cc(N2CCC3(CC2)CC([C@H]2C[C@@H]2C#Cc2cccc4c2CN(C2CCC(=O)NC2=O)C4=O)C3)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C56H59Cl2FN6O5 986.029000 |
IMHSPCKBQXBAHB-GUVGVTSASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725176; PubChem:CID164592095
|
Local ready
Direct docking supported
|
|
E3L036060
BDB036060
|
US20250073340, Example 24
COc1cc(C(=O)N2CCC[C@H](CC#Cc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)C2)ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@@]2(CNc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C52H53Cl2FN6O6 947.936000 |
BZUIBNLKEGFPOY-PCSFOWHGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM725177; PubChem:CID164592138
|
Local ready
Direct docking supported
|