| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L018041
BDB018041
|
US10576064, Example I-235
O=C(O)c1ccc(N2C[C@@H]3[C@H](C2=O)[C@@H](c2cccc(Cl)c2F)[C@@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CCCCC2)cc1
|
C33H30Cl2FN3O4 622.524000 |
UOKCCCWRVOUWDJ-CPWWYQHDSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432014; PubChem:CID118636542
|
Local ready
Direct docking supported
|
|
E3L018042
BDB018042
|
US10576064, Example I-236
O=C(O)c1ccc(N2C[C@@H]3[C@H](C2=O)[C@@H](c2cccc(Cl)c2F)[C@@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CCCC2)cc1
|
C32H28Cl2FN3O4 608.497000 |
ZMJCOYHKPNQQTR-NIWNGRQCSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432015; PubChem:CID118636540
|
Local ready
Direct docking supported
|
|
E3L018043
BDB018043
|
US10576064, Example I-237
CCOc1cccc(CN2[C@H]3CN(c4ccc(C(=O)O)cc4)C(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C35H28Cl2FN3O5 660.529000 |
GGRFJALKAQMSHZ-VLWKUZPGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432016; PubChem:CID118636541
|
Local ready
Direct docking supported
|
|
E3L018044
BDB018044
|
US10576064, Example I-239
CCOc1cccc(CN2[C@@H]3CN(c4ccc(C(=O)O)cc4)C(=O)[C@@H]3[C@@H](c3cccc(Cl)c3F)[C@@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C35H28Cl2FN3O5 660.529000 |
GGRFJALKAQMSHZ-OYTZIAQDSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432018; PubChem:CID118636543
|
Local ready
Direct docking supported
|
|
E3L018045
BDB018045
|
US10576064, Example I-240
CCOc1cccc(CN2[C@H]3CN(c4ccc(C(=O)O)cc4)C(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2nc(Cl)ccc23)c1
|
C34H27Cl2FN4O5 661.517000 |
NZOIMVOCNHPBPF-ZJXHMCRVSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432019; PubChem:CID118636546
|
Local ready
Direct docking supported
|
|
E3L018046
BDB018046
|
US10576064, Example I-242
O=C(O)c1ccc(CN2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H26Cl2FN3O4 594.470000 |
CKQLOHUNHQNOCR-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432020; PubChem:CID118636544
|
Local ready
Direct docking supported
|
|
E3L018047
BDB018047
|
US10576064, Example I-244
O=C(O)c1ccc(N2C[C@H]3[C@@H](C2=O)[C@H](c2ccnc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C29H23Cl2FN4O4 581.431000 |
XFCMUQOSKLGGOI-LQZKXZFMSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432021; PubChem:CID118636545
|
Local ready
Direct docking supported
|
|
E3L018048
BDB018048
|
US10576064, Example I-246
CCOc1cccc(CN2[C@H]3CN(Cc4ccc(C(=O)O)cc4)C(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H30Cl2FN3O5 674.556000 |
QVGKXDXTIRCXOG-GHFJTSGJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432022; PubChem:CID118636547
|
Local ready
Direct docking supported
|
|
E3L018049
BDB018049
|
US10576064, Example I-248
CCOc1cccc(CN2[C@H]3CN(Cc4ccc(C(=O)O)cc4)C(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H30Cl2FN3O5 674.556000 |
QVGKXDXTIRCXOG-NDCXGSNASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432023; PubChem:CID118636548
|
Local ready
Direct docking supported
|
|
E3L018050
BDB018050
|
US10576064, Example I-250
COc1cc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Br)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)ccc1C(=O)O
|
C31H26BrClFN3O5 654.920000 |
PKTGZTQYOQJNFO-BQNOKLPLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432024; PubChem:CID118636551
|
Local ready
Direct docking supported
|
|
E3L018051
BDB018051
|
US10576064, Example I-252
O=C(O)c1ccc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Br)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C30H24BrClFN3O4 624.894000 |
YTNXBNQQSGJLEA-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432025; PubChem:CID118636549
|
Local ready
Direct docking supported
|
|
E3L018052
BDB018052
|
US10576064, Example I-254
O=C(O)c1ccc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Br)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1F
|
C30H23BrClF2N3O4 642.884000 |
JBXUNGYCUHDTIM-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432026; PubChem:CID118636556
|
Local ready
Direct docking supported
|
|
E3L018053
BDB018053
|
US10576064, Example I-256
O=C(O)c1ccc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1C(F)(F)F
|
C31H23Cl2F4N3O4 648.440000 |
TVOGDVGFZPMWSM-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432027; PubChem:CID118636552
|
Local ready
Direct docking supported
|
|
E3L018054
BDB018054
|
US10576064, Example I-258
COc1cc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)ccc1C(=O)O
|
C31H26Cl2FN3O5 610.469000 |
LHGJVNBEMDMBEK-BQNOKLPLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432028; PubChem:CID118636559
|
Local ready
Direct docking supported
|
|
E3L018055
BDB018055
|
US10576064, Example I-259
O=C(O)c1ccc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1OC(F)(F)F
|
C31H23Cl2F4N3O5 664.439000 |
JKFVLIJZEJBEQV-MOLUGRFGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432029; PubChem:CID118636553
|
Local ready
Direct docking supported
|
|
E3L018056
BDB018056
|
US10576064, Example I-261
Cc1cc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)ccc1C(=O)O
|
C31H26Cl2FN3O4 594.470000 |
XHLUGAYRBGWLAE-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432030; PubChem:CID118636555
|
Local ready
Direct docking supported
|
|
E3L018057
BDB018057
|
US10576064, Example I-262
O=C(CO)c1ccc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H26Cl2FN3O4 594.470000 |
CGKUCDNYIVSVMH-AXWQWZDISA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432031; PubChem:CID118636554
|
Local ready
Direct docking supported
|
|
E3L018058
BDB018058
|
US10576064, Example I-264
O=C(O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)c(O)c1
|
C31H26Cl2FN3O5 610.469000 |
LCPJHNXNKKROSP-BQNOKLPLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432032; PubChem:CID118636557
|
Local ready
Direct docking supported
|
|
E3L018059
BDB018059
|
US10576064, Example I-266
O=C1[C@@H]2[C@H](CCN1c1cc(F)c(O)c(F)c1)N(CC1CC1)[C@@]1(C(=O)Nc3cc(Cl)ccc31)[C@H]2c1cccc(Cl)c1F
|
C30H24Cl2F3N3O3 602.440000 |
OSYJDYWFWLRNPX-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432033; PubChem:CID118636558
|
Local ready
Direct docking supported
|
|
E3L018060
BDB018060
|
US10576064, Example I-268
NC(=O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H27Cl2FN4O3 593.486000 |
HIEAMRFJIWRBLX-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM432034; PubChem:CID118636560
|
Local ready
Direct docking supported
|