| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L018001
BDB018001
|
US10576064, Example I-86
N#Cc1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H25Cl2FN4O2 575.471000 |
XBSZXJYQQZDTED-OVDFTCDZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431968; PubChem:CID118641670
|
Local ready
Direct docking supported
|
|
E3L018002
BDB018002
|
US10576064, Example I-90
COCc1cc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)ccn1
|
C31H29Cl2FN4O3 595.502000 |
XKFAOKFYLUFIHI-OVDFTCDZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431970; PubChem:CID118636465
|
Local ready
Direct docking supported
|
|
E3L018003
BDB018003
|
US10576064, Example I-92
O=C1[C@@H]2[C@H](CCN1c1ccncc1)N(CC1CC1)[C@@]1(C(=O)Nc3cc(Cl)ccc31)[C@H]2c1cccc(Cl)c1F
|
C29H25Cl2FN4O2 551.449000 |
TXHYCYFXLLTZPN-APSVEGKFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431971; PubChem:CID118636466
|
Local ready
Direct docking supported
|
|
E3L018004
BDB018004
|
US10576064, Example I-112
CCOc1cccc(CN2[C@@H]3CCN(c4ccc(C(=O)OC)cc4)C(=O)[C@@H]3[C@@H](c3cccc(Cl)c3F)[C@@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C37H32Cl2FN3O5 688.583000 |
VGSXOTBOORJFRS-BNSAVYCWSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431972; PubChem:CID118636475
|
Local ready
Direct docking supported
|
|
E3L018005
BDB018005
|
US10576064, Example I-123
COC(=O)c1ccc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H26Cl2FN3O4 594.470000 |
JYMSQSYXNDEFLP-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431973; PubChem:CID118636401
|
Local ready
Direct docking supported
|
|
E3L018006
BDB018006
|
US10576064, Example I-125
COC(=O)c1ccc(N2C[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)c(OC)c1
|
C32H28Cl2FN3O5 624.496000 |
PCYAPBYGFQWGSX-VLDXSALASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431974; PubChem:CID118636481
|
Local ready
Direct docking supported
|
|
E3L018007
BDB018007
|
US10576064, Example I-170
O=C(O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H26Cl2FN3O4 594.470000 |
BVIIEJXEZARDLB-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431975; PubChem:CID118636506
|
Local ready
Direct docking supported
|
|
E3L018008
BDB018008
|
US10576064, Example I-172
O=C(O)c1ccc(N2CC[C@@H]3[C@H](C2=O)[C@@H](c2cccc(Cl)c2F)[C@@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H26Cl2FN3O4 594.470000 |
BVIIEJXEZARDLB-ANKKVJNISA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431978; PubChem:CID118636507
|
Local ready
Direct docking supported
|
|
E3L018009
BDB018009
|
US10576064, Example I-173
O=C(O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)c(F)cc42)N3CC2CC2)cc1
|
C31H25Cl2F2N3O4 612.460000 |
NGKFEFWXSCLAIW-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431979; PubChem:CID118636508
|
Local ready
Direct docking supported
|
|
E3L018010
BDB018010
|
US10576064, Example I-175
O=C(O)c1cccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)c1
|
C31H26Cl2FN3O4 594.470000 |
XVENFNUZISCQBV-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431980; PubChem:CID118636509
|
Local ready
Direct docking supported
|
|
E3L018011
BDB018011
|
US10576064, Example I-177
O=C(O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H27Cl2N3O4 576.480000 |
LSEDINPIYBNLHK-OVDFTCDZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431981; PubChem:CID118636510
|
Local ready
Direct docking supported
|
|
E3L018012
BDB018012
|
US10576064, Example I-179
COc1cc(C(=O)O)ccc1N1CC[C@H]2[C@@H](C1=O)[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H28Cl2FN3O5 624.496000 |
GFDZGAXDRROIHF-VLDXSALASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431982; PubChem:CID118636511
|
Local ready
Direct docking supported
|
|
E3L018013
BDB018013
|
US10576064, Example I-181
COc1cc(C(=O)O)ccc1N1CC[C@H]2[C@@H](C1=O)[C@H](c1cccc(Cl)c1)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H29Cl2N3O5 606.506000 |
CKOPLNQGWUOZKS-GUGCCZFXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431983; PubChem:CID118636512
|
Local ready
Direct docking supported
|
|
E3L018014
BDB018014
|
US10576064, Example I-183
O=C(O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cn1
|
C30H25Cl2FN4O4 595.458000 |
NDQAVYAZELNUII-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431984; PubChem:CID118636513
|
Local ready
Direct docking supported
|
|
E3L018015
BDB018015
|
US10576064, Example I-185
CCOc1cccc(CN2[C@H]3CCN(c4ccc(C(=O)O)cc4)C(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H30Cl2FN3O5 674.556000 |
WTPJSXGFKZFZIP-GHFJTSGJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431985; PubChem:CID118636514
|
Local ready
Direct docking supported
|
|
E3L018016
BDB018016
|
US10576064, Example I-188
CCOc1cccc(CN2[C@H]3CCN(c4ccc(C(=O)O)cc4[N+](=O)[O-])C(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H29Cl2FN4O7 719.553000 |
ULRLUPDUVDFWFH-WTNSZDBTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431987; PubChem:CID118636515
|
Local ready
Direct docking supported
|
|
E3L018017
BDB018017
|
US10576064, Example I-190
CC1CC1CN1[C@H]2CCN(c3ccc(C(=O)O)cc3F)C(=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H27Cl2F2N3O4 626.487000 |
DKRVHWFZTSAQGG-NAQLUNFCSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431988; PubChem:CID118636516
|
Local ready
Direct docking supported
|
|
E3L018018
BDB018018
|
US10576064, Example I-192
O=C(O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)c([N+](=O)[O-])c1
|
C31H25Cl2FN4O6 639.467000 |
OKAONPLLYIEKHP-BQNOKLPLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431989; PubChem:CID118636518
|
Local ready
Direct docking supported
|
|
E3L018019
BDB018019
|
US10576064, Example I-194
COc1cc(C(=O)O)ccc1N1CC[C@H]2[C@@H](C1=O)[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1C
|
C33H30Cl2FN3O5 638.523000 |
VRVIZIFFCQLHSA-WWHCCTFESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431990; PubChem:CID118636519
|
Local ready
Direct docking supported
|
|
E3L018020
BDB018020
|
US10576064, Example I-196
CC1CC1CN1[C@H]2CCN(c3ccc(C(=O)O)cc3)C(=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H28Cl2FN3O4 608.497000 |
SDTJUBHEBJCILM-BOBXHHBQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431991; PubChem:CID118636520
|
Local ready
Direct docking supported
|