| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L017981
BDB017981
|
US10576064, Example I-13
CC1CC1CN1[C@H]2CCNC(=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C25H24Cl2FN3O2 488.390000 |
OMLKETOKEHFMEI-XSZZCNFYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431943; PubChem:CID118641395
|
Local ready
Direct docking supported
|
|
E3L017982
BDB017982
|
US10576064, Example I-15
CC(C)(C)CN1[C@H]2CCNC(=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C25H26Cl2FN3O2 490.406000 |
PPAASGXUPBXBHZ-PBQROFAYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431944; PubChem:CID118639998
|
Local ready
Direct docking supported
|
|
E3L017983
BDB017983
|
US10576064, Example I-17
O=C1NCC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)c(F)cc31)N2CC1CC1
|
C24H21Cl2F2N3O2 492.353000 |
IVTLJFWIZFHEAJ-CMCWBKRRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431945; PubChem:CID118641397
|
Local ready
Direct docking supported
|
|
E3L017984
BDB017984
|
US10576064, Example I-19
O=C1NCC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CCC1
|
C25H24Cl2FN3O2 488.390000 |
FZWRMSNIZHOASX-UGCAPWQASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431946; PubChem:CID118641414
|
Local ready
Direct docking supported
|
|
E3L017985
BDB017985
|
US10576064, Example I-21
O=C1NCC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Br)ccc31)N2CC1CC1
|
C24H22BrClFN3O2 518.814000 |
FUEQSGNCAAERRF-CMCWBKRRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431947; PubChem:CID118641416
|
Local ready
Direct docking supported
|
|
E3L017986
BDB017986
|
US10576064, Example I-23
Cc1ccc2c(c1)NC(=O)[C@]21[C@@H](c2cccc(Cl)c2F)[C@@H]2C(=O)NCC[C@@H]2N1CC1CC1
|
C25H25ClFN3O2 453.945000 |
CXGLDLHDCINSII-UGCAPWQASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431948; PubChem:CID118641608
|
Local ready
Direct docking supported
|
|
E3L017987
BDB017987
|
US10576064, Example I-25
O=C1NCC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(I)ccc31)N2CC1CC1
|
C24H22ClFIN3O2 565.814000 |
PYECWGGXFHYXAA-CMCWBKRRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431949; PubChem:CID118641438
|
Local ready
Direct docking supported
|
|
E3L017988
BDB017988
|
US10576064, Example I-37
O=C1OCC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C24H21Cl2FN2O3 475.347000 |
WLNUUZXQWHRJMY-CMCWBKRRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431951; PubChem:CID118636450
|
Local ready
Direct docking supported
|
|
E3L017989
BDB017989
|
US10576064, Example I-39
O=C1NC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C23H20Cl2FN3O2 460.336000 |
GWTBHRUJZBKDEJ-QPXQOZNCSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431952; PubChem:CID118641619
|
Local ready
Direct docking supported
|
|
E3L017990
BDB017990
|
US10576064, Example I-43
CCOc1cccc(CN2[C@H]3CNC(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C28H24Cl2FN3O3 540.422000 |
RVSCWTMYEZULKX-NLJXWPIHSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431955; PubChem:CID118641415
|
Local ready
Direct docking supported
|
|
E3L017991
BDB017991
|
US10576064, Example I-63
COC(=O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C32H28Cl2FN3O4 608.497000 |
MOTOMQOCFHZTGB-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431956; PubChem:CID118636453
|
Local ready
Direct docking supported
|
|
E3L017992
BDB017992
|
US10576064, Example I-69
COC(=O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2C)cc1
|
C33H30Cl2FN3O4 622.524000 |
OYOQFNJTEDMLIV-YFNQUQPFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431958; PubChem:CID118636456
|
Local ready
Direct docking supported
|
|
E3L017993
BDB017993
|
US10576064, Example I-71
CCOc1cccc(CN2[C@H]3CCN(c4ccc(C(=O)OC)cc4)C(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C37H32Cl2FN3O5 688.583000 |
VGSXOTBOORJFRS-AWYYSMRRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431959; PubChem:CID118636457
|
Local ready
Direct docking supported
|
|
E3L017994
BDB017994
|
US10576064, Example I-72
O=C1[C@@H]2[C@H](CCN1c1ccc(-c3nnn[nH]3)cc1)N(CC1CC1)[C@@]1(C(=O)Nc3cc(Cl)ccc31)[C@H]2c1cccc(Cl)c1F
|
C31H26Cl2FN7O2 618.500000 |
BWEOITLIKXJEDJ-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431960; PubChem:CID118636458
|
Local ready
Direct docking supported
|
|
E3L017995
BDB017995
|
US10576064, Example I-74
CC(C)(C)CN1[C@H]2CCN(c3ccc(S(C)(=O)=O)cc3)C(=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H32Cl2FN3O4S 644.596000 |
NYMRZYNWEZDSML-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431961; PubChem:CID118636459
|
Local ready
Direct docking supported
|
|
E3L017996
BDB017996
|
US10576064, Example I-76
CS(=O)(=O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H28Cl2FN3O4S 628.553000 |
WRBBCJRCHRHMFD-OVDFTCDZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431962; PubChem:CID118636460
|
Local ready
Direct docking supported
|
|
E3L017997
BDB017997
|
US10576064, Example I-78
CC1CC1CN1[C@H]2CCN(c3ccc(S(C)(=O)=O)cc3)C(=O)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H30Cl2FN3O4S 642.580000 |
GWCFMGAEWPTFHF-ADAOSWSCSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431963; PubChem:CID118636461
|
Local ready
Direct docking supported
|
|
E3L017998
BDB017998
|
US10576064, Example I-80
CNS(=O)(=O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)cc1
|
C31H29Cl2FN4O4S 643.568000 |
NZNKQAZJSTZOJW-OVDFTCDZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431964; PubChem:CID118640003
|
Local ready
Direct docking supported
|
|
E3L017999
BDB017999
|
US10576064, Example I-82
COC(=O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2C)c(OC)c1
|
C34H32Cl2FN3O5 652.550000 |
CLNVJZMDILHUCP-FPXITODQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431966; PubChem:CID118636462
|
Local ready
Direct docking supported
|
|
E3L018000
BDB018000
|
US10576064, Example I-84
COC(=O)c1ccc(N2CC[C@H]3[C@@H](C2=O)[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2C)c(F)c1
|
C33H29Cl2F2N3O4 640.514000 |
URTZYKDJGHBLLA-NCFJUCFHSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431967; PubChem:CID118636463
|
Local ready
Direct docking supported
|