| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L019201
BDB019201
|
US10717742, Example Ia-32
CCOc1cccc(CN2[C@H]3Cc4c5ccc(C(=O)O)cc5nn4[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C35H27Cl2FN4O4 657.529000 |
YDCYDDDGLGQAFA-BUZHNBETSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454376; PubChem:CID129264138
|
Local ready
Direct docking supported
|
|
E3L019202
BDB019202
|
US10717742, Example Ia-33
Cc1cc2c3n(nc2cc1C(=O)O)[C@@H]1[C@H](C3)N(CC2CC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C31H25Cl2FN4O3 591.470000 |
QQKVUSCOLBRBAO-OCCLXFBYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454377; PubChem:CID129264139
|
Local ready
Direct docking supported
|
|
E3L019203
BDB019203
|
Brigimadlin
Cc1c(C(=O)O)ccc2c3n(nc12)[C@@H]1[C@H](C3)N(CC2CC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C31H25Cl2FN4O3 591.470000 |
AMTXDBGKYPDTTA-SJVQGLCSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454378; PubChem:CID129264140
|
Local ready
Direct docking supported
|
|
E3L019204
BDB019204
|
US10717742, Example Ia-35
COc1cc2c3n(nc2cc1C(=O)O)[C@@H]1[C@H](C3)N(CC2CC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C31H25Cl2FN4O4 607.469000 |
HELWHOCPNPKQES-XYKPQQNDSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454379; PubChem:CID129264141
|
Local ready
Direct docking supported
|
|
E3L019205
BDB019205
|
US10717742, Example Ia-36
COc1c(C(=O)O)ccc2c3n(nc12)[C@@H]1[C@H](C3)N(CC2CC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C31H25Cl2FN4O4 607.469000 |
AJVHPFSTOSQFKH-NFCLTKQRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454380; PubChem:CID129264142
|
Local ready
Direct docking supported
|
|
E3L019206
BDB019206
|
US10717742, Example Ia-38
O=C(O)c1ccc2nn3c(c2c1)C[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C30H23Cl2FN4O3 577.443000 |
NQBLVFSQNANGBM-VBVRERCOSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454381; PubChem:CID129264143
|
Local ready
Direct docking supported
|
|
E3L019207
BDB019207
|
US10717742, Example Ia-39
Cc1cc2c3n(nc2cc1C(=O)O)[C@@H]1[C@H](C3)N(CC(C)C)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C31H27Cl2FN4O3 593.486000 |
KXHYWHUCIUFBSN-OCCLXFBYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454382; PubChem:CID129264144
|
Local ready
Direct docking supported
|
|
E3L019208
BDB019208
|
US10717742, Example Ia-40
CCOc1cccc(CN2[C@H]3Cc4c5cc(C)c(C(=O)O)cc5nn4[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H29Cl2FN4O4 671.556000 |
UHVPLUOTGRLCBM-VKOIOGAXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454383; PubChem:CID129264147
|
Local ready
Direct docking supported
|
|
E3L019209
BDB019209
|
US10717742, Example Ia-41
O=C(O)c1ccc2c3n(nc2c1)[C@@H]1[C@H](C3)N(CC2CC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1ccnc(Cl)c1F
|
C29H22Cl2FN5O3 578.431000 |
XEKJGEPAZRWKHH-WSQBEXMKSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454384; PubChem:CID129264145
|
Local ready
Direct docking supported
|
|
E3L019210
BDB019210
|
US10717742, Example Ia-43
O=C(O)c1ccc2c3n(nc2c1)[C@@H]1[C@H](C3)N(CC2CC2)[C@@]2(C(=O)Nc3nc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C29H22Cl2FN5O3 578.431000 |
LPDZTJPCRROKAL-CEEAJLFKSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454385; PubChem:CID129264146
|
Local ready
Direct docking supported
|
|
E3L019211
BDB019211
|
US10717742, Example Ia-46
CC(C)(O)CNC(=O)c1ccc2c3n(nc2c1)[C@@H]1[C@H](C3)N(CC2CCC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C35H34Cl2FN5O3 662.593000 |
DXZXWOIDPRNJIQ-FHBKDIMNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454386; PubChem:CID129264149
|
Local ready
Direct docking supported
|
|
E3L019212
BDB019212
|
US10717742, Example Ia-47
O=C(NC1CC1)c1ccc2c3n(nc2c1)[C@@H]1[C@H](C3)N(CC2CCC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C34H30Cl2FN5O2 630.551000 |
ZCULFHDDGIIOCY-AXEVPAOMSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454387; PubChem:CID129028625
|
Local ready
Direct docking supported
|
|
E3L019213
BDB019213
|
US10717742, Example Ia-48
COCC(COC)NC(=O)c1ccc2c3n(nc2c1)[C@@H]1[C@H](C3)N(CC2CCC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C36H36Cl2FN5O4 692.619000 |
WELWXIJLPFCACP-VKOIOGAXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454388; PubChem:CID129271279
|
Local ready
Direct docking supported
|
|
E3L019214
BDB019214
|
US10717742, Example Ia-49
COCCOCCNC(=O)c1ccc2c3n(nc2c1)[C@@H]1[C@H](C3)N(CC2CCC2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
|
C36H36Cl2FN5O4 692.619000 |
KCHJQXIVDLRSMV-VKOIOGAXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454389; PubChem:CID129271242
|
Local ready
Direct docking supported
|
|
E3L019215
BDB019215
|
US10717742, Example Ia-50
CCN1[C@H]2Cc3c4ccc(C(=O)NCCO)cc4nn3[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C30H26Cl2FN5O3 594.474000 |
OEURXXSPBOPJQW-VBVRERCOSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454390; PubChem:CID129271262
|
Local ready
Direct docking supported
|
|
E3L019216
BDB019216
|
US10717742, Example Ia-51
CCN1[C@H]2Cc3c4ccc(C(=O)NCCN(C)C)cc4nn3[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H31Cl2FN6O2 621.544000 |
GUZFCPUHQQRKAS-MRFOFCOLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454391; PubChem:CID129271232
|
Local ready
Direct docking supported
|
|
E3L019217
BDB019217
|
US10717742, Example Ia-52
CCN1[C@H]2Cc3c4ccc(C(=O)N5CCCCC5)cc4nn3[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C33H30Cl2FN5O2 618.540000 |
IHPOMFMLXRFCPP-JLHVHBRNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454392; PubChem:CID129264150
|
Local ready
Direct docking supported
|
|
E3L019218
BDB019218
|
US10717742, Example Ia-53
CCN1[C@H]2Cc3c4ccc(C(=O)NC5(C)COC5)cc4nn3[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H28Cl2FN5O3 620.512000 |
WAVIVNWGPHGQCW-CKHSQSCFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454393; PubChem:CID129270916
|
Local ready
Direct docking supported
|
|
E3L019219
BDB019219
|
US10717742, Example Ia-54
CCOc1cccc(CN2[C@H]3Cc4c5cc(C)c(C(=O)N6CCOCC6)cc5nn4[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C40H36Cl2FN5O4 740.663000 |
VSJUHGDNPHKDJK-MIUFGTTASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454394; PubChem:CID129264151
|
Local ready
Direct docking supported
|
|
E3L019220
BDB019220
|
US10717742, Example Ia-55
CCOc1cccc(CN2[C@H]3Cc4c5cc(C)c(C(=O)NCCOC)cc5nn4[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C39H36Cl2FN5O4 728.652000 |
PRWUEPICLXFUSS-YWXVCWFGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454395; PubChem:CID129264153
|
Local ready
Direct docking supported
|