| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L019241
BDB019241
|
US10717742, Example Ib-133
CS(=O)(=O)CCCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C31H27Cl2FN4O5S 657.551000 |
WTNLZAVGEVTJLT-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454419; PubChem:CID129028669
|
Local ready
Direct docking supported
|
|
E3L019242
BDB019242
|
US10717742, Example Ib-135
O=C(O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CCCC1
|
C33H29Cl2FN4O3 619.524000 |
XPDPFSRMJNZENB-UUZIFAJNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454420; PubChem:CID129028791
|
Local ready
Direct docking supported
|
|
E3L019243
BDB019243
|
US10717742, Example Ib-137
O=C(O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CCCCC1
|
C34H31Cl2FN4O3 633.551000 |
MSLCKEWYQDLVDL-HKRZWTHNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454421; PubChem:CID129028793
|
Local ready
Direct docking supported
|
|
E3L019244
BDB019244
|
US10717742, Example Ib-139
CCOc1cccc(CN2[C@H]3CCn4c(nc5cc(C(=O)O)ccc54)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H29Cl2FN4O4 671.556000 |
NTPHWEOQINJKPH-GHFJTSGJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454422; PubChem:CID129029125
|
Local ready
Direct docking supported
|
|
E3L019245
BDB019245
|
US10717742, Example Ib-141
CCOc1cccc(CN2[C@@H]3CCn4c(nc5cc(C(=O)O)ccc54)[C@@H]3[C@@H](c3cccc(Cl)c3F)[C@@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H29Cl2FN4O4 671.556000 |
NTPHWEOQINJKPH-RKVFUFCESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454424; PubChem:CID129264197
|
Local ready
Direct docking supported
|
|
E3L019246
BDB019246
|
US10717742, Example Ib-142
COCc1cccc(CN2[C@H]3CCn4c(nc5cc(C(=O)O)ccc54)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H29Cl2FN4O4 671.556000 |
JVGLCJXHEWXRKQ-GHFJTSGJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454425; PubChem:CID129029126
|
Local ready
Direct docking supported
|
|
E3L019247
BDB019247
|
US10717742, Example Ib-144
COc1cccc(CCN2[C@H]3CCn4c(nc5cc(C(=O)O)ccc54)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H29Cl2FN4O4 671.556000 |
MOEOMIOFXYAELD-GHFJTSGJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454426; PubChem:CID129029147
|
Local ready
Direct docking supported
|
|
E3L019248
BDB019248
|
US10717742, Example Ib-146
O=C(O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CCC(F)(F)F
|
C30H22Cl2F4N4O3 633.429000 |
JDDGLBCRVKDGBD-WUBQMYJQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454427; PubChem:CID129029039
|
Local ready
Direct docking supported
|
|
E3L019249
BDB019249
|
US10717742, Example Ib-148
N#CC12CC(CN3[C@H]4CCn5c(nc6cc(C(=O)O)ccc65)[C@H]4[C@H](c4cccc(Cl)c4F)[C@]34C(=O)Nc3cc(Cl)ccc34)(C1)C2
|
C34H26Cl2FN5O3 642.518000 |
ANQOOLPOFBFHFG-AGFCVEEUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454428; PubChem:CID129029038
|
Local ready
Direct docking supported
|
|
E3L019250
BDB019250
|
US10717742, Example Ib-150
CC(C)(C)CN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H29Cl2FN4O3 607.513000 |
FQAOMKSDLZLGSZ-ZVJSOJQNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454429; PubChem:CID129028679
|
Local ready
Direct docking supported
|
|
E3L019251
BDB019251
|
US10717742, Example Ib-152
N#Cc1ccc2c(c1)NC(=O)[C@]21[C@@H](c2cccc(Cl)c2F)[C@@H]2c3nc4cc(C(=O)O)ccc4n3CC[C@@H]2N1CC1CC1
|
C32H25ClFN5O3 582.035000 |
KZJCMKHQPUSMLK-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454430; PubChem:CID129028677
|
Local ready
Direct docking supported
|
|
E3L019252
BDB019252
|
US10717742, Example Ib-154
O=C(O)c1ccc2nc3n(c2c1)CC[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C31H25Cl2FN4O3 591.470000 |
MKBJIZRDQRBZSE-BQNOKLPLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454431; PubChem:CID129028670
|
Local ready
Direct docking supported
|
|
E3L019253
BDB019253
|
US10717742, Example Ib-156
O=C(O)c1cccc2nc3n(c12)CC[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C31H25Cl2FN4O3 591.470000 |
QNGFKQMDBVAPSU-TXHDDHBJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454433; PubChem:CID129028668
|
Local ready
Direct docking supported
|
|
E3L019254
BDB019254
|
US10717742, Example Ib-157
COc1cc2c(cc1C(=O)O)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H27Cl2FN4O4 621.496000 |
ORCCYZDVDADXFG-YIZCCYSQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454434; PubChem:CID129028671
|
Local ready
Direct docking supported
|
|
E3L019255
BDB019255
|
US10717742, Example Ib-158
O=C(O)c1cc2nc3n(c2cc1OC(F)(F)F)CC[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C32H24Cl2F4N4O4 675.466000 |
NDNONTWPXWZORQ-ZFXCNGLTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454435; PubChem:CID129028672
|
Local ready
Direct docking supported
|
|
E3L019256
BDB019256
|
US10717742, Example Ib-159
Cc1cc2c(cc1C(=O)O)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H27Cl2FN4O3 605.497000 |
JVVZMJYPJMVKKZ-VLDXSALASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454436; PubChem:CID129028801
|
Local ready
Direct docking supported
|
|
E3L019257
BDB019257
|
US10717742, Example Ib-160
Cc1c(C(=O)O)ccc2c1nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H27Cl2FN4O3 605.497000 |
QICHMFJHIQNRPD-COTPXHMFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454437; PubChem:CID129028802
|
Local ready
Direct docking supported
|
|
E3L019258
BDB019258
|
US10717742, Example Ib-161
Cc1cc2c(nc3n2CC[C@H]2[C@@H]3[C@H](c3cccc(Cl)c3F)[C@]3(C(=O)Nc4cc(Cl)ccc43)N2CC2CC2)c(C)c1C(=O)O
|
C33H29Cl2FN4O3 619.524000 |
VZOXWGWWWOIBFC-YLHDPFPMSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454438; PubChem:CID129028797
|
Local ready
Direct docking supported
|
|
E3L019259
BDB019259
|
US10717742, Example Ib-162
CC(C)c1cc2c(cc1C(=O)O)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C34H31Cl2FN4O3 633.551000 |
NSPKRTODNDPPDO-CUXVDNJVSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454439; PubChem:CID129264198
|
Local ready
Direct docking supported
|
|
E3L019260
BDB019260
|
US10717742, Example Ib-163
O=C(O)c1cc2nc3n(c2cc1F)CC[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C31H24Cl2F2N4O3 609.460000 |
LHSMZMARFUDLBW-BQNOKLPLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454440; PubChem:CID129028614
|
Local ready
Direct docking supported
|