| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L019261
BDB019261
|
US10717742, Example Ib-164
O=C(O)c1cc2nc3n(c2cc1C(F)(F)F)CC[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C32H24Cl2F4N4O3 659.467000 |
UWRFEFGLXRXFTL-BQNOKLPLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454442; PubChem:CID129028615
|
Local ready
Direct docking supported
|
|
E3L019262
BDB019262
|
US10717742, Example Ib-165
O=C(O)C1(c2ccc3c(c2)nc2n3CC[C@H]3[C@@H]2[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)CC1
|
C34H29Cl2FN4O3 631.535000 |
WSMZRCQEOFKOHE-CWFKBQJKSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454443; PubChem:CID129028611
|
Local ready
Direct docking supported
|
|
E3L019263
BDB019263
|
US10717742, Example Ib-167
CC(C)(C(=O)O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C34H31Cl2FN4O3 633.551000 |
VIQVDPHQKJURQA-CWFKBQJKSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454444; PubChem:CID129028620
|
Local ready
Direct docking supported
|
|
E3L019264
BDB019264
|
US10717742, Example Ib-169
O=C(O)Cc1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H27Cl2FN4O3 605.497000 |
HDSJYAKGGVKHJG-GUGCCZFXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454445; PubChem:CID129028621
|
Local ready
Direct docking supported
|
|
E3L019265
BDB019265
|
US10717742, Example Ib-171
O=C(O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3nc(Cl)ccc31)N2CC1CC1
|
C30H24Cl2FN5O3 592.458000 |
DJVOYCHJTOEHCO-SFDBNFMMSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454446; PubChem:CID129029024
|
Local ready
Direct docking supported
|
|
E3L019266
BDB019266
|
US10717742, Example Ib-173
CCOc1cccc(CN2[C@H]3CCn4c(nc5cc(C(=O)O)ccc54)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2nc(Cl)ccc23)c1
|
C35H28Cl2FN5O4 672.544000 |
UMVNJUCFYCNWHI-BIQPUALYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454447; PubChem:CID129028630
|
Local ready
Direct docking supported
|
|
E3L019267
BDB019267
|
US10717742, Example Ib-175
O=C(O)c1ccc2c(c1)nc1n2C[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C30H23Cl2FN4O3 577.443000 |
ATOWJKYDKJUMIK-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454448; PubChem:CID129028628
|
Local ready
Direct docking supported
|
|
E3L019268
BDB019268
|
US10717742, Example Ib-177
O=C(O)c1ccc2c(c1)nc1n2C[C@@H]2[C@H]1[C@@H](c1cccc(Cl)c1F)[C@@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C30H23Cl2FN4O3 577.443000 |
ATOWJKYDKJUMIK-ZXPXOXBPSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454450; PubChem:CID129028622
|
Local ready
Direct docking supported
|
|
E3L019269
BDB019269
|
US10717742, Example Ib-178
O=C(O)c1ccc2nc3n(c2c1)C[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C30H23Cl2FN4O3 577.443000 |
MPHBGIAYRPDSFY-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454451; PubChem:CID129028738
|
Local ready
Direct docking supported
|
|
E3L019270
BDB019270
|
US10717742, Example Ib-180
O=C(O)c1ccc2nc3n(c2c1)C[C@@H]1[C@H]3[C@@H](c2cccc(Cl)c2F)[C@@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C30H23Cl2FN4O3 577.443000 |
MPHBGIAYRPDSFY-ZXPXOXBPSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454453; PubChem:CID129028743
|
Local ready
Direct docking supported
|
|
E3L019271
BDB019271
|
US10717742, Example Ib-183
COCc1cccc(CN2[C@H]3Cn4c(nc5cc(C(=O)O)ccc54)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C35H27Cl2FN4O4 657.529000 |
VZTQEQCYEHIMGJ-VLWKUZPGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454454; PubChem:CID129264200
|
Local ready
Direct docking supported
|
|
E3L019272
BDB019272
|
US10717742, Example Ib-185
COCc1cccc(CN2[C@@H]3Cn4c(nc5cc(C(=O)O)ccc54)[C@@H]3[C@@H](c3cccc(Cl)c3F)[C@@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C35H27Cl2FN4O4 657.529000 |
VZTQEQCYEHIMGJ-OYTZIAQDSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454456; PubChem:CID129264201
|
Local ready
Direct docking supported
|
|
E3L019273
BDB019273
|
US10717742, Example Ib-186
COc1cccc(CCN2[C@H]3Cn4c(nc5cc(C(=O)O)ccc54)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C35H27Cl2FN4O4 657.529000 |
IVOMVBNEHOOKDE-VLWKUZPGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454457; PubChem:CID129264202
|
Local ready
Direct docking supported
|
|
E3L019274
BDB019274
|
US10717742, Example Ib-188
Cc1cc2c(cc1C(=O)O)nc1n2C[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C31H25Cl2FN4O3 591.470000 |
JACDOGSGIMWWHW-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454458; PubChem:CID129028800
|
Local ready
Direct docking supported
|
|
E3L019275
BDB019275
|
US10717742, Example Ib-189
Cc1c(C(=O)O)ccc2c1nc1n2C[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C31H25Cl2FN4O3 591.470000 |
JANVYBFCTRMKJM-TXHDDHBJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454459; PubChem:CID129028798
|
Local ready
Direct docking supported
|
|
E3L019276
BDB019276
|
US10717742, Example Ib-191
CCN1[C@H]2Cn3c(nc4cc(C(=O)O)c(C)cc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C29H23Cl2FN4O3 565.432000 |
KAHIRLWYUBUOQB-HNFJUSDZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454461; PubChem:CID129264203
|
Local ready
Direct docking supported
|
|
E3L019277
BDB019277
|
US10717742, Example Ib-193
O=C(O)c1ccc2c(nc3n2C[C@H]2[C@@H]3[C@H](c3cccc(Cl)c3F)[C@]3(C(=O)Nc4cc(Cl)ccc43)N2CC2CC2)c1C(F)(F)F
|
C31H22Cl2F4N4O3 645.440000 |
XZTFORAJFXAHPJ-XOCMKLHTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454462; PubChem:CID129029031
|
Local ready
Direct docking supported
|
|
E3L019278
BDB019278
|
US10717742, Example Ib-195
O=C(O)c1cc2nc3n(c2cc1C(F)(F)F)C[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C31H22Cl2F4N4O3 645.440000 |
LINXBFOMGYWYOE-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454463; PubChem:CID129029209
|
Local ready
Direct docking supported
|
|
E3L019279
BDB019279
|
US10717742, Example Ib-197
O=C(O)c1cc2nc3n(c2cc1OC(F)(F)F)C[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C31H22Cl2F4N4O4 661.439000 |
UFXHEMIFWUYXLN-MOLUGRFGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454464; PubChem:CID129264204
|
Local ready
Direct docking supported
|
|
E3L019280
BDB019280
|
US10717742, Example Ib-198
O=C(O)c1ccc2c(c1)nc1n2C[C@H]2[C@@H]1[C@H](c1cccc(Br)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C30H23BrClFN4O3 621.894000 |
LDIXAVJMQGSTNF-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454465; PubChem:CID129028660
|
Local ready
Direct docking supported
|