| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L019221
BDB019221
|
US10717742, Example Ia-56
CCOc1cccc(CN2[C@H]3Cc4c5cc(C)c(C(=O)NC)cc5nn4[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C37H32Cl2FN5O3 684.599000 |
JWZNHZLLLSGXCP-IZOLSYHTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454396; PubChem:CID129264152
|
Local ready
Direct docking supported
|
|
E3L019222
BDB019222
|
US10717742, Example Ia-57
CCOc1cccc(CN2[C@H]3Cc4c5cc(C)c(C(=O)N(C)C)cc5nn4[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C38H34Cl2FN5O3 698.626000 |
SZERUKUVLUHCAZ-GKECXJKSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454397; PubChem:CID129264154
|
Local ready
Direct docking supported
|
|
E3L019223
BDB019223
|
US10717742, Example Ib-49
CCOc1cccc(CN2[C@H]3Cn4c(nc5cc(C(=O)OC)ccc54)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C36H29Cl2FN4O4 671.556000 |
XLNXPYHNJFUGES-GHFJTSGJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454398; PubChem:CID129028768
|
Local ready
Direct docking supported
|
|
E3L019224
BDB019224
|
US10717742, Example Ib-57
CS(=O)(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C31H27Cl2FN4O3S 625.553000 |
FNMPKTZLYBGKAD-OVDFTCDZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454399; PubChem:CID129264190
|
Local ready
Direct docking supported
|
|
E3L019225
BDB019225
|
US10717742, Example Ib-59
CC(=O)Nc1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H28Cl2FN5O2 604.513000 |
JVDIKXQGLMGPAR-CKXMCULTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454401; PubChem:CID129028591
|
Local ready
Direct docking supported
|
|
E3L019226
BDB019226
|
US10717742, Example Ib-66
COC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC=C(C)C
|
C33H29Cl2FN4O3 619.524000 |
JVNYGJHSCDCMJH-UUZIFAJNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454402; PubChem:CID129028674
|
Local ready
Direct docking supported
|
|
E3L019227
BDB019227
|
US10717742, Example Ib-106
O=C(O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C31H25Cl2FN4O3 591.470000 |
JXTRBTNBCFNEOH-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454403; PubChem:CID129028424
|
Local ready
Direct docking supported
|
|
E3L019228
BDB019228
|
US10717742, Example Ib-108
O=C(O)c1ccc2c(c1)nc1n2CC[C@@H]2[C@H]1[C@@H](c1cccc(Cl)c1F)[C@@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C31H25Cl2FN4O3 591.470000 |
JXTRBTNBCFNEOH-ANKKVJNISA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454405; PubChem:CID129028425
|
Local ready
Direct docking supported
|
|
E3L019229
BDB019229
|
US10717742, Example Ib-109
CC(C)CN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C31H27Cl2FN4O3 593.486000 |
BTLOWMGXRJMQPO-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454406; PubChem:CID129028794
|
Local ready
Direct docking supported
|
|
E3L019230
BDB019230
|
US10717742, Example Ib-111
CCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C29H23Cl2FN4O3 565.432000 |
DUBSUJXQXBPSGO-HNFJUSDZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454408; PubChem:CID129029146
|
Local ready
Direct docking supported
|
|
E3L019231
BDB019231
|
US10717742, Example Ib-113
CCCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C30H25Cl2FN4O3 579.459000 |
QIDCDWNATSVEBK-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454409; PubChem:CID129029144
|
Local ready
Direct docking supported
|
|
E3L019232
BDB019232
|
US10717742, Example Ib-115
CCCCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C31H27Cl2FN4O3 593.486000 |
JHUNVZBNDYXUIE-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454410; PubChem:CID129029022
|
Local ready
Direct docking supported
|
|
E3L019233
BDB019233
|
US10717742, Example Ib-117
CCCCCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H29Cl2FN4O3 607.513000 |
GDEQHTBWQSMYSH-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454411; PubChem:CID129029023
|
Local ready
Direct docking supported
|
|
E3L019234
BDB019234
|
US10717742, Example Ib-119
CC(C)CCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H29Cl2FN4O3 607.513000 |
ILYVOFWUIQMRIK-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454412; PubChem:CID129029017
|
Local ready
Direct docking supported
|
|
E3L019235
BDB019235
|
US10717742, Example Ib-121
CC(C)=CCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H27Cl2FN4O3 605.497000 |
DEUVTWNOCCPOEG-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454413; PubChem:CID129029018
|
Local ready
Direct docking supported
|
|
E3L019236
BDB019236
|
US10717742, Example Ib-123
O=C(O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CCC1
|
C32H27Cl2FN4O3 605.497000 |
MQGPRZWDRNPPFE-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454414; PubChem:CID129029210
|
Local ready
Direct docking supported
|
|
E3L019237
BDB019237
|
US10717742, Example Ib-125
O=C(O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC(F)(F)C1
|
C32H25Cl2F3N4O3 641.477000 |
RCDHCKVLSLGUCX-ZVJSOJQNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454415; PubChem:CID129029211
|
Local ready
Direct docking supported
|
|
E3L019238
BDB019238
|
US10717742, Example Ib-127
COCCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C30H25Cl2FN4O4 595.458000 |
MLEFIAUJFMKFGR-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454416; PubChem:CID129028796
|
Local ready
Direct docking supported
|
|
E3L019239
BDB019239
|
US10717742, Example Ib-129
CC(C)OCCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C32H29Cl2FN4O4 623.512000 |
UHUQMQVIKGZMSC-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454417; PubChem:CID129028795
|
Local ready
Direct docking supported
|
|
E3L019240
BDB019240
|
US10717742, Example Ib-131
CC(C)(C)OCCN1[C@H]2CCn3c(nc4cc(C(=O)O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C33H31Cl2FN4O4 637.539000 |
KZDNSLZBBRMVPG-LIHQSLCGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454418; PubChem:CID129028667
|
Local ready
Direct docking supported
|