| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L019281
BDB019281
|
US10717742, Example Ib-200
O=C(O)c1ccc2c(c1)nc1n2C[C@H]2[C@@H]1[C@H](c1cc(Cl)cs1)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C28H22Cl2N4O3S 565.482000 |
NPOODSMWCHNWHR-DSZDGCDSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454466; PubChem:CID129028661
|
Local ready
Direct docking supported
|
|
E3L019282
BDB019282
|
US10717742, Example Ib-202
O=C(O)c1ccc2c(c1)nc1n2C[C@H]2[C@@H]1[C@H](c1ccc(Cl)s1)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C28H22Cl2N4O3S 565.482000 |
AQNWJCKIXUOWAQ-GXCDUKDASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454467; PubChem:CID129029123
|
Local ready
Direct docking supported
|
|
E3L019283
BDB019283
|
US10717742, Example Ib-204
Cc1c(C(=O)O)ccc2nc3n(c12)CC[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C32H27Cl2FN4O3 605.497000 |
VKVZULSPZNMZMD-ZVJSOJQNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454468; PubChem:CID129264205
|
Local ready
Direct docking supported
|
|
E3L019284
BDB019284
|
US10717742, Example Ib-205
Cc1cc(C(=O)O)cc2c1nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H27Cl2FN4O3 605.497000 |
FTTAOLGWQSREEI-COTPXHMFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454469; PubChem:CID129264206
|
Local ready
Direct docking supported
|
|
E3L019285
BDB019285
|
US10717742, Example Ib-207
Cc1c(C(=O)O)ccc2c1nc1n2CC[C@H]2[C@@H]1[C@H](c1ccnc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C31H26Cl2FN5O3 606.485000 |
MMELGTWRMKFXRI-DDXTWNMFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454471; PubChem:CID129028616
|
Local ready
Direct docking supported
|
|
E3L019286
BDB019286
|
US10717742, Example Ib-209
CNC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H28Cl2FN5O2 604.513000 |
WPTZHFDBFKEDCJ-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454472; PubChem:CID129028781
|
Local ready
Direct docking supported
|
|
E3L019287
BDB019287
|
US10717742, Example Ib-210
NC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C31H26Cl2FN5O2 590.486000 |
HDBOSKDUONHFQV-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454473; PubChem:CID129028421
|
Local ready
Direct docking supported
|
|
E3L019288
BDB019288
|
US10717742, Example Ib-211
CN(C)C(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C33H30Cl2FN5O2 618.540000 |
CMXIHXVPQXANLZ-UUZIFAJNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454474; PubChem:CID129028422
|
Local ready
Direct docking supported
|
|
E3L019289
BDB019289
|
US10717742, Example Ib-212
O=C(NC1CC1)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C34H30Cl2FN5O2 630.551000 |
CKILDVGNICTJSV-HKRZWTHNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454475; PubChem:CID129028423
|
Local ready
Direct docking supported
|
|
E3L019290
BDB019290
|
US10717742, Example Ib-213
CC(C)(O)CNC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C35H34Cl2FN5O3 662.593000 |
PCCLVVMCECDDPF-LQHHRKQYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454476; PubChem:CID129271026
|
Local ready
Direct docking supported
|
|
E3L019291
BDB019291
|
US10717742, Example Ib-214
O=C(NC(CO)CO)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C34H32Cl2FN5O4 664.565000 |
VWTXLXQXUVZREP-HKRZWTHNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454477; PubChem:CID129271139
|
Local ready
Direct docking supported
|
|
E3L019292
BDB019292
|
US10717742, Example Ib-215
O=C(NCCO)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C33H30Cl2FN5O3 634.539000 |
JLGAHDXIZKNWPK-UUZIFAJNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454478; PubChem:CID129028478
|
Local ready
Direct docking supported
|
|
E3L019293
BDB019293
|
US10717742, Example Ib-216
COCCNC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C34H32Cl2FN5O3 648.566000 |
ZHTKIZJBAAYJQX-HKRZWTHNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454479; PubChem:CID129028686
|
Local ready
Direct docking supported
|
|
E3L019294
BDB019294
|
US10717742, Example Ib-217
COCC(COC)NC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C36H36Cl2FN5O4 692.619000 |
UONGMIYERODONO-GHFJTSGJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454480; PubChem:CID129028687
|
Local ready
Direct docking supported
|
|
E3L019295
BDB019295
|
US10717742, Example Ib-218
O=C(NC(CO)(CO)CO)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C35H34Cl2FN5O5 694.591000 |
XEJLWMHUKGMEPZ-LQHHRKQYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454481; PubChem:CID129271333
|
Local ready
Direct docking supported
|
|
E3L019296
BDB019296
|
US10717742, Example Ib-219
COCCOCCNC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C36H36Cl2FN5O4 692.619000 |
NWHBAUVNLSANAR-GHFJTSGJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454482; PubChem:CID129271337
|
Local ready
Direct docking supported
|
|
E3L019297
BDB019297
|
US10717742, Example Ib-220
O=C(c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1)N1CCOCC1
|
C35H32Cl2FN5O3 660.577000 |
VZPCNTURLBXKDW-VLWKUZPGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454483; PubChem:CID129029213
|
Local ready
Direct docking supported
|
|
E3L019298
BDB019298
|
US10717742, Example Ib-221
CN1CCN(C(=O)c2ccc3c(c2)nc2n3CC[C@H]3[C@@H]2[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)CC1
|
C36H35Cl2FN6O2 673.620000 |
CJMUQGAFZPIZGQ-GHFJTSGJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454484; PubChem:CID129029214
|
Local ready
Direct docking supported
|
|
E3L019299
BDB019299
|
US10717742, Example Ib-222
NCCNC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C33H31Cl2FN6O2 633.555000 |
NZQIJRDYZYIKJK-UUZIFAJNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454485; PubChem:CID129028624
|
Local ready
Direct docking supported
|
|
E3L019300
BDB019300
|
US10717742, Example Ib-223
CN(C)CCNC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C35H35Cl2FN6O2 661.609000 |
ANEGSPDUPXASTB-VLWKUZPGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454486; PubChem:CID129271358
|
Local ready
Direct docking supported
|