| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L019301
BDB019301
|
US10717742, Example Ib-224
CS(=O)(=O)CCNC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C34H32Cl2FN5O4S 696.632000 |
AYLAJGGIUMTHNI-HKRZWTHNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454487; PubChem:CID129028627
|
Local ready
Direct docking supported
|
|
E3L019302
BDB019302
|
US10717742, Example Ib-225
CC1(NC(=O)c2ccc3c(c2)nc2n3CC[C@H]3[C@@H]2[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)COC1
|
C35H32Cl2FN5O3 660.577000 |
QKUJQIKDYBOEFP-LQHHRKQYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454488; PubChem:CID129271036
|
Local ready
Direct docking supported
|
|
E3L019303
BDB019303
|
US10717742, Example Ib-226
CC1(CNC(=O)c2ccc3c(c2)nc2n3CC[C@H]3[C@@H]2[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)COC1
|
C36H34Cl2FN5O3 674.604000 |
POHANRYGOXKUTQ-BBJOTMRQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454489; PubChem:CID129028683
|
Local ready
Direct docking supported
|
|
E3L019304
BDB019304
|
US10717742, Example Ib-227
O=C(c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1)N1CC(O)C1
|
C34H30Cl2FN5O3 646.550000 |
CPHYAVTULLMFGD-HKRZWTHNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454490; PubChem:CID129028684
|
Local ready
Direct docking supported
|
|
E3L019305
BDB019305
|
US10717742, Example Ib-228
CN1CC(NC(=O)c2ccc3c(c2)nc2n3CC[C@H]3[C@@H]2[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc4cc(Cl)ccc42)N3CC2CC2)C1
|
C35H33Cl2FN6O2 659.593000 |
GCHOXSWWKJSDNZ-VLWKUZPGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454491; PubChem:CID129029221
|
Local ready
Direct docking supported
|
|
E3L019306
BDB019306
|
US10717742, Example Ib-229
O=C(NC1COCC1O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C35H32Cl2FN5O4 676.576000 |
YUIXARRUBNOMHM-DRNSZEMUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454492; PubChem:CID129029223
|
Local ready
Direct docking supported
|
|
E3L019307
BDB019307
|
US10717742, Example Ib-230
CN(O)C(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C32H28Cl2FN5O3 620.512000 |
PBBJAFYCUPEMEQ-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454493; PubChem:CID129029222
|
Local ready
Direct docking supported
|
|
E3L019308
BDB019308
|
US10717742, Example Ib-231
O=C(NO)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C31H26Cl2FN5O3 606.485000 |
DDAALDOHDIGXCX-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454494; PubChem:CID129028681
|
Local ready
Direct docking supported
|
|
E3L019309
BDB019309
|
US10717742, Example Ib-232
CC(C)CN1[C@H]2CCn3c(nc4cc(C(N)=O)ccc43)[C@H]2[C@H](c2cccc(Cl)c2F)[C@]12C(=O)Nc1cc(Cl)ccc12
|
C31H28Cl2FN5O2 592.502000 |
WUMFGGNGAWFETN-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454495; PubChem:CID129028675
|
Local ready
Direct docking supported
|
|
E3L019310
BDB019310
|
US10717742, Example Ib-233
CNC(=O)c1ccc2c(c1)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC(C)C
|
C32H30Cl2FN5O2 606.529000 |
BCFFEVZCSKXMMG-ACIRYHQQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454496; PubChem:CID129271369
|
Local ready
Direct docking supported
|
|
E3L019311
BDB019311
|
US10717742, Example Ib-234
COc1cc2c(cc1C(N)=O)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC(C)C
|
C32H30Cl2FN5O3 622.528000 |
OONYSWRCVCNYJY-YIZCCYSQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454497; PubChem:CID140916964
|
Local ready
Direct docking supported
|
|
E3L019312
BDB019312
|
US10717742, Example Ib-235
CNC(=O)c1cc2nc3n(c2cc1OC)CC[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C33H30Cl2FN5O3 634.539000 |
HPFGSLFSJFPVSA-AZRHWCIMSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454498; PubChem:CID129028334
|
Local ready
Direct docking supported
|
|
E3L019313
BDB019313
|
US10717742, Example Ib-236
COc1cc2c(cc1C(=O)N(C)C)nc1n2CC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C34H32Cl2FN5O3 648.566000 |
HKHDQJOWZDWLQF-QEFYAOKTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454499; PubChem:CID129264207
|
Local ready
Direct docking supported
|
|
E3L019314
BDB019314
|
US10717742, Example Ib-237
CNC(=O)c1cc2nc3n(c2cc1C)CC[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C33H30Cl2FN5O2 618.540000 |
KFWCDXPSBYHIFY-JLLCTVPFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454500; PubChem:CID129264208
|
Local ready
Direct docking supported
|
|
E3L019315
BDB019315
|
US10717742, Example Ib-238
NC(=O)c1ccc2nc3n(c2c1)CC[C@H]1[C@@H]3[C@H](c2cccc(Cl)c2F)[C@]2(C(=O)Nc3cc(Cl)ccc32)N1CC1CC1
|
C31H26Cl2FN5O2 590.486000 |
NCBUGOQYTUSFEK-BQNOKLPLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454501; PubChem:CID129264209
|
Local ready
Direct docking supported
|
|
E3L019316
BDB019316
|
US10717742, Example Ib-239
NC(=O)c1ccc2c(c1)nc1n2C[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C30H24Cl2FN5O2 576.459000 |
DXZCIDCHOKFYEG-YDXRHMNESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454502; PubChem:CID129029048
|
Local ready
Direct docking supported
|
|
E3L019317
BDB019317
|
US10717742, Example Ib-240
CNC(=O)c1ccc2c(c1)nc1n2C[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C31H26Cl2FN5O2 590.486000 |
PAJLMUHEXNRKFW-GURVGDRESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454503; PubChem:CID129029049
|
Local ready
Direct docking supported
|
|
E3L019318
BDB019318
|
US10717742, Example Ib-241
CCOc1cccc(CN2[C@H]3Cn4c(nc5cc(C(N)=O)ccc54)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C35H28Cl2FN5O3 656.545000 |
YMILTUNEZUXRAI-VLWKUZPGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454504; PubChem:CID129264210
|
Local ready
Direct docking supported
|
|
E3L019319
BDB019319
|
US10717742, Example Ib-243
CCOc1cccc(CN2[C@@H]3Cn4c(nc5cc(C(N)=O)ccc54)[C@@H]3[C@@H](c3cccc(Cl)c3F)[C@@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C35H28Cl2FN5O3 656.545000 |
YMILTUNEZUXRAI-OYTZIAQDSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454506; PubChem:CID129029030
|
Local ready
Direct docking supported
|
|
E3L019320
BDB019320
|
US10717742, Example Ib-244
CCOc1cccc(CN2[C@H]3Cn4c(nc5cc(C(=O)NO)ccc54)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C35H28Cl2FN5O4 672.544000 |
UEFJJQGFIIYIDV-VLWKUZPGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM454507; PubChem:CID129271354
|
Local ready
Direct docking supported
|