| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L023461
BDB023461
|
US11236047, Example 94
CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cc1)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1)c1cn(C)cn1
|
C34H32ClFN4O4 615.105000 |
ZOWAIYZZMIRJLG-MUADHRSZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535267; PubChem:CID135281488
|
Local ready
Direct docking supported
|
|
E3L023462
BDB023462
|
US11236047, Example 32
CC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)cc1)[C@@]2(OCC1(CO)CCC1)c1ccc(Cl)cc1
|
C30H31Cl2NO4 540.487000 |
OYVZDYIWPZZTME-SSEXGKCCSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535269; PubChem:CID135281405
|
Local ready
Direct docking supported
|
|
E3L023463
BDB023463
|
US10544132, Example 118
CCO[C@]1(c2ccc(Cl)cc2)c2c(F)cc([C@](O)(CC)C3CCOCC3)cc2C(=O)N1Cc1ccc(Cl)cc1C(=O)O
|
C32H32Cl2FNO6 616.513000 |
DLUFTCNJNCOQGS-AJQTZOPKSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535278; PubChem:CID135281631
|
Local ready
Direct docking supported
|
|
E3L023464
BDB023464
|
BDBM535282
CC[C@@](O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cc1CC(=O)O)[C@@]2(OC)c1ccc(Cl)cc1)C1CCOCC1
|
C32H32Cl2FNO6 616.513000 |
KSQHEVCOEVTEOI-AJQTZOPKSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535282; PubChem:CID135281582
|
Local ready
Direct docking supported
|
|
E3L023465
BDB023465
|
US11236047, Example 105
CC[C@@](O)(c1cc(F)c2c(c1)C(=O)N([C@@H](CC(=O)O)c1ccc(Cl)cc1)[C@@]2(OC)c1ccc(Cl)cc1)C1CCOCC1
|
C32H32Cl2FNO6 616.513000 |
TXTARTLLGHDDSD-SUXPEFEVSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535286; PubChem:CID135281588
|
Local ready
Direct docking supported
|
|
E3L023466
BDB023466
|
US11236047, Example 90
CCC(O)(c1cc(F)c2c(c1)C(=O)N([C@@H](CO)c1ccc(C#N)cc1)[C@@]2(O[C@H]1CCOC1)c1ccc(Cl)cc1)c1cn(C)cn1
|
C34H32ClFN4O5 631.104000 |
DLDOXTZEZBHSKM-OJHXNHCWSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535294; PubChem:CID135281652
|
Local ready
Direct docking supported
|
|
E3L023467
BDB023467
|
US11236047, Example 112
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCN(C)C(=O)C3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H30Cl2N4O4 569.489000 |
DZIHXZOXUTVDGM-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535295; PubChem:CID135283185
|
Local ready
Direct docking supported
|
|
E3L023468
BDB023468
|
US11236047, Example 103
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CCC3)cc2C(=O)N1[C@@H](CC(=O)O)c1ccc(Cl)cc1
|
C30H28Cl2FNO5 572.460000 |
BVCCIEZECAVANS-NIJCYXJWSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535301; PubChem:CID135281441
|
Local ready
Direct docking supported
|
|
E3L023469
BDB023469
|
BDBM535305
CC(C)(O)c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(OC[C@H]1C[C@H](O)C1)c1ccc(Cl)cc1
|
C29H27ClFN3O4 536.003000 |
BMTZOKAZWFZZTA-WPGLZZBSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM535305
|
Local ready
Direct docking supported
|
|
E3L023470
BDB023470
|
US11236047, Example 319
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)C3CCN(C)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H31Cl2N3O3 540.491000 |
XDRDDFDNMPCGJS-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535306; PubChem:CID135282540
|
Local ready
Direct docking supported
|
|
E3L023471
BDB023471
|
US11236047, Example 382
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CC[C@H](O)C3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C28H29Cl2N3O4 542.463000 |
HRIJPCHUKWYMAZ-FNPAGISBSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535307; PubChem:CID135282701
|
Local ready
Direct docking supported
|
|
E3L023472
BDB023472
|
US11236047, Example 243
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCCNCC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H32Cl2N4O3 555.506000 |
PQOGDMMHRYSZLL-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535308; PubChem:CID135282570
|
Local ready
Direct docking supported
|
|
E3L023473
BDB023473
|
US11236047, Example 241
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCNC(=O)C3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C28H28Cl2N4O4 555.462000 |
VPGDQGXCZJKOKB-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535309; PubChem:CID135282586
|
Local ready
Direct docking supported
|
|
E3L023474
BDB023474
|
US11236047, Example 239
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN(C)C3CCN(C)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C31H36Cl2N4O3 583.560000 |
NIQLOSGJNQWVPZ-NLIBRCFJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535310; PubChem:CID135282584
|
Local ready
Direct docking supported
|
|
E3L023475
BDB023475
|
US11236047, Example 247
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCC(O)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H31Cl2N3O4 556.490000 |
KKZFHPXILKNMKT-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535311; PubChem:CID135282781
|
Local ready
Direct docking supported
|
|
E3L023476
BDB023476
|
US11236047, Example 237
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCN(CCO)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C30H34Cl2N4O4 585.532000 |
DPPXNNDVKLQDMN-BDCODIICSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535312; PubChem:CID135282491
|
Local ready
Direct docking supported
|
|
E3L023477
BDB023477
|
US11236047, Example 240
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CNC3CCOCC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H31Cl2N3O4 556.490000 |
NNFNCIHBRADXMA-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535313; PubChem:CID135282709
|
Local ready
Direct docking supported
|
|
E3L023478
BDB023478
|
US11236047, Example 159
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)Cn3ccnc3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C27H24Cl2N4O3 523.420000 |
YGKSMVLPXSQVDL-SSYAZFEXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535314; PubChem:CID135282840
|
Local ready
Direct docking supported
|
|
E3L023479
BDB023479
|
US11236047, Example 167
C[C@@H](CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(C)O)cc2C(=O)N1Cc1ccc(Cl)cn1)C(N)=O
|
C27H26Cl2FN3O4 546.426000 |
BQIHMGXSJXBAHX-KUNJGFBQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535315; PubChem:CID135282097
|
Local ready
Direct docking supported
|
|
E3L023480
BDB023480
|
US11236047, Example 253a
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN(C)C3CCN(C(C)=O)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C32H36Cl2N4O4 611.570000 |
WILRRCSJAZCUSZ-IADGFXSZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535316; PubChem:CID135282547
|
Local ready
Direct docking supported
|