| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L023521
BDB023521
|
US11236047, Example 305
CN1CCC(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(C(N)=O)CC2)c2ccc(Cl)cc2)CC1
|
C33H35Cl2FN4O4 641.571000 |
KMIRBOKBTSMCMR-NFCCVXSLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535369; PubChem:CID135282857
|
Local ready
Direct docking supported
|
|
E3L023522
BDB023522
|
US11236047, Example 282
CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(OCC1(C#N)CC1)c1ccc(Cl)cc1)C1CCOCC1
|
C33H30ClFN4O4 601.078000 |
JPIAYQWVJXBMJC-NFCCVXSLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535370; PubChem:CID135282567
|
Local ready
Direct docking supported
|
|
E3L023523
BDB023523
|
US11236047, Example 304
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CCN(C)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H30Cl2FN3O3 558.481000 |
YBXWZLZVYYJBMD-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535371; PubChem:CID135282417
|
Local ready
Direct docking supported
|
|
E3L023524
BDB023524
|
US11236047, Example 161
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)c3cn(C)c(C)n3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C28H25Cl2FN4O3 555.437000 |
LGLFXSZJTQXTAU-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535372; PubChem:CID135283115
|
Local ready
Direct docking supported
|
|
E3L023525
BDB023525
|
US11236047, Example 308
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CN(C)C3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C27H26Cl2FN3O3 530.427000 |
YKMGWHSTFXEMCZ-SSYAZFEXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535374; PubChem:CID135282602
|
Local ready
Direct docking supported
|
|
E3L023526
BDB023526
|
US11236047, Example 200
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(O)CC2)c2ccc(Cl)cc2)cn1
|
C30H27Cl2FN4O4 597.474000 |
PFXVXXVCBJFYSR-FUJFQHJFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535375; PubChem:CID135282831
|
Local ready
Direct docking supported
|
|
E3L023527
BDB023527
|
US11236047, Example 189
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)c3ccn(C)n3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C27H23Cl2FN4O3 541.410000 |
YOBNVSIBCUFROP-SSYAZFEXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535376; PubChem:CID135283096
|
Local ready
Direct docking supported
|
|
E3L023528
BDB023528
|
BDBM535378
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(O[C@H]2C[C@@H](O)C2)c2ccc(Cl)cc2)cn1
|
C30H27Cl2FN4O4 597.474000 |
FGIFVIRKAVOOKP-YUNFXOIVSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM535378
|
Local ready
Direct docking supported
|
|
E3L023529
BDB023529
|
BDBM535379
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(O[C@H]2C[C@H](O)C2)c2ccc(Cl)cc2)cn1
|
C30H27Cl2FN4O4 597.474000 |
FGIFVIRKAVOOKP-UBUFSOAJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM535379
|
Local ready
Direct docking supported
|
|
E3L023530
BDB023530
|
US11236047, Example 315
COc1nc(C)ccc1CN1C(=O)c2cc(C(C)(C)O)cc(F)c2[C@]1(OC)c1ccc(Cl)cc1
|
C26H26ClFN2O4 484.955000 |
MTDAGGJDNAEGRS-AREMUKBSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535380; PubChem:CID135282458
|
Local ready
Direct docking supported
|
|
E3L023531
BDB023531
|
US11236047, Example 163
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)c3ncc[nH]3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C26H21Cl2FN4O3 527.383000 |
GKKVPUFXVAIQNW-FXDYGKIASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535381; PubChem:CID135282410
|
Local ready
Direct docking supported
|
|
E3L023532
BDB023532
|
US11236047, Example 165
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)c3nccs3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C26H20Cl2FN3O3S 544.435000 |
WJXYQJKFZGKOIF-FXDYGKIASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535383; PubChem:CID135282667
|
Local ready
Direct docking supported
|
|
E3L023533
BDB023533
|
US11236047, Example 298
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CCN(C(=O)CN(C)C)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C32H35Cl2FN4O4 629.560000 |
JSDUYCYXQIMWBH-IADGFXSZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535385; PubChem:CID135282927
|
Local ready
Direct docking supported
|
|
E3L023534
BDB023534
|
US11236047, Example 191
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)c3cnn(CCN(C)C)c3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C30H30Cl2FN5O3 598.506000 |
LGDXNVXHJCEZCK-BDCODIICSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535387; PubChem:CID137497966
|
Local ready
Direct docking supported
|
|
E3L023535
BDB023535
|
US11236047, Example 286
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CCN(c4ncccn4)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C32H30Cl2FN5O3 622.528000 |
LMBZJFUAYACSDA-IADGFXSZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535389; PubChem:CID135282487
|
Local ready
Direct docking supported
|
|
E3L023536
BDB023536
|
US11236047, Example 293
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CCN(C(C)=N)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C30H31Cl2FN4O3 585.507000 |
VGACYBQLPGODGA-BDCODIICSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535390; PubChem:CID163407646
|
Local ready
Direct docking supported
|
|
E3L023537
BDB023537
|
US11236047, Example 209
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(F)cn2)[C@@]3(OCC2(C(N)=O)CC2)c2ccc(Cl)cc2)cn1
|
C31H28ClF2N5O4 608.045000 |
KNNAAOMNPYTAMJ-ZGVDRVBQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535391; PubChem:CID135282347
|
Local ready
Direct docking supported
|
|
E3L023538
BDB023538
|
US11236047, Example 187
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)c3cn(C)nn3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C26H22Cl2FN5O3 542.398000 |
SVSYHJNAJSDECL-FXDYGKIASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535392; PubChem:CID135282110
|
Local ready
Direct docking supported
|
|
E3L023539
BDB023539
|
US11236047, Example 294
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CCN(S(C)(=O)=O)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H30Cl2FN3O5S 622.546000 |
OCUUERPPLFZCFN-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535393; PubChem:CID135282530
|
Local ready
Direct docking supported
|
|
E3L023540
BDB023540
|
US11236047, Example 197
Cc1nc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(C(N)=O)CC2)c2ccc(Cl)cc2)cn1C
|
C32H30Cl2FN5O4 638.527000 |
RINWORWTFDLZQT-BDJZEIKTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535394; PubChem:CID135282960
|
Local ready
Direct docking supported
|