| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L023481
BDB023481
|
US11236047, Example 249
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCS(=O)(=O)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C28H29Cl2N3O5S 590.529000 |
KREFOPSIIIDQPU-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535317; PubChem:CID137498041
|
Local ready
Direct docking supported
|
|
E3L023482
BDB023482
|
US11236047, Example 250
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCC[C@H]3CO)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H31Cl2N3O4 556.490000 |
JFFLEFUMQHMYIZ-QLMXRQDHSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535318; PubChem:CID135282683
|
Local ready
Direct docking supported
|
|
E3L023483
BDB023483
|
US11236047, Example 320
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)c3ccccn3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C28H23Cl2N3O3 520.416000 |
AEIKRFTUDLNFOQ-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535319; PubChem:CID135282337
|
Local ready
Direct docking supported
|
|
E3L023484
BDB023484
|
US11236047, Example 257
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCCC3=O)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C28H27Cl2N3O4 540.447000 |
LEGWQUAVGNVBCC-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535321; PubChem:CID135282785
|
Local ready
Direct docking supported
|
|
E3L023485
BDB023485
|
US11236047, Example 255
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCN(C)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H32Cl2N4O3 555.506000 |
ZGKBSBXWXVIPTA-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535322; PubChem:CID135282565
|
Local ready
Direct docking supported
|
|
E3L023486
BDB023486
|
US11236047, Example 259
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCC(N)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H32Cl2N4O3 555.506000 |
YWQGLDHZKOMWAR-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535323; PubChem:CID135282311
|
Local ready
Direct docking supported
|
|
E3L023487
BDB023487
|
US11236047, Example 324
Cc1nc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(O)CC2)c2ccc(Cl)cc2)cn1C
|
C31H29Cl2FN4O4 611.501000 |
VZJXEPGTXSZTFT-ZGVDRVBQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535325; PubChem:CID135283141
|
Local ready
Direct docking supported
|
|
E3L023488
BDB023488
|
US11236047, Example 261
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCNC(=O)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H30Cl2N4O4 569.489000 |
VTTCUOOPEDMGDZ-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535326; PubChem:CID135282751
|
Local ready
Direct docking supported
|
|
E3L023489
BDB023489
|
US11236047, Example 169
C[C@@H](c1ccc(C#N)cn1)N1C(=O)c2cc(C(C)(C)O)cc(F)c2[C@]1(OCC1(CO)CC1)c1ccc(Cl)cc1
|
C30H29ClFN3O4 550.030000 |
ZTHJYOMAEPHLCZ-YVGXBJCXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535327; PubChem:CID135282773
|
Local ready
Direct docking supported
|
|
E3L023490
BDB023490
|
US11236047, Example 262
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCn4nncc4C3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H28Cl2N6O3 579.488000 |
VHIUFRHFXUUDAW-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535328; PubChem:CID135282942
|
Local ready
Direct docking supported
|
|
E3L023491
BDB023491
|
US11236047, Example 234
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)COc3cccnc3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H25Cl2N3O4 550.442000 |
OSFLWVFFCXOKFW-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535329; PubChem:CID135282449
|
Local ready
Direct docking supported
|
|
E3L023492
BDB023492
|
US11236047, Example 264
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3C[C@H]4C[C@@H]3CN4C)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C30H32Cl2N4O3 567.517000 |
PBBNOTCNGPJVQE-ILVBBMGSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535332; PubChem:CID137513243
|
Local ready
Direct docking supported
|
|
E3L023493
BDB023493
|
US11236047, Example 236
CCOCC(C)(O)c1ccc2c(c1)C(=O)N(Cc1ccc(Cl)cn1)[C@@]2(OC)c1ccc(Cl)cc1
|
C26H26Cl2N2O4 501.410000 |
WQLWSRLBJFQPMN-FXDYGKIASA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535333; PubChem:CID135282505
|
Local ready
Direct docking supported
|
|
E3L023494
BDB023494
|
US11236047, Example 316
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(C#N)cn2)[C@@]3(OCC2(CO)CC2)c2ccc(Cl)cc2)cn1
|
C32H29ClFN5O4 602.066000 |
GCKLTVVEUHWDDO-BDJZEIKTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535334; PubChem:CID135282782
|
Local ready
Direct docking supported
|
|
E3L023495
BDB023495
|
US11236047, Example 377
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)COC3CCNCC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H31Cl2N3O4 556.490000 |
OEHYQQAEGJJOGR-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535336; PubChem:CID135282350
|
Local ready
Direct docking supported
|
|
E3L023496
BDB023496
|
US11236047, Example 376
CC(=O)N1CCC(C(C)(O)c2ccc3c(c2)C(=O)N(Cc2ccc(Cl)cn2)C3(O)c2ccc(Cl)cc2)CC1
|
C29H29Cl2N3O4 554.474000 |
YZQDUBHOKBMFJN-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535337; PubChem:CID140963863
|
Local ready
Direct docking supported
|
|
E3L023497
BDB023497
|
US11236047, Example 303
CC(=O)N1CCC(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(C(N)=O)CC2)c2ccc(Cl)cc2)CC1
|
C34H35Cl2FN4O5 669.581000 |
JNWIBTVWXFDIHN-SZFCLFMZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535338; PubChem:CID135282309
|
Local ready
Direct docking supported
|
|
E3L023498
BDB023498
|
US11236047, Example 266
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCCN(C)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C30H34Cl2N4O3 569.533000 |
UYAUDKAFRBHDQL-BDCODIICSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535339; PubChem:CID135282525
|
Local ready
Direct docking supported
|
|
E3L023499
BDB023499
|
US11236047, Example 265
CO[C@]1(c2ccc(Cl)cc2)c2ccc(C(C)(O)CN3CCC[C@@H]3CO)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H31Cl2N3O4 556.490000 |
JFFLEFUMQHMYIZ-ZOPIJBJZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535340; PubChem:CID135282677
|
Local ready
Direct docking supported
|
|
E3L023500
BDB023500
|
US11236047, Example 289
CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1)C1CCNCC1
|
C33H34ClFN4O4 605.110000 |
NFSWATKGUGXRKR-NFCCVXSLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535341; PubChem:CID135282279
|
Local ready
Direct docking supported
|