| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L023541
BDB023541
|
US11236047, Example 211
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(C#N)cn2)[C@@]3(OCC2(C#N)CC2)c2ccc(Cl)cc2)cn1
|
C32H26ClFN6O3 597.050000 |
RKSMIALTWWALNY-BDJZEIKTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535396; PubChem:CID135283189
|
Local ready
Direct docking supported
|
|
E3L023542
BDB023542
|
US11236047, Example 201
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(C#N)CC2)c2ccc(Cl)cc2)cn1
|
C31H26Cl2FN5O3 606.485000 |
VDKMMDFDHKJNRA-ZGVDRVBQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535397; PubChem:CID135282589
|
Local ready
Direct docking supported
|
|
E3L023543
BDB023543
|
US11236047, Example 193
CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cn1)[C@@]2(OCC1(C(N)=O)CC1)c1ccc(Cl)cc1)c1cscn1
|
C30H25Cl2FN4O4S 627.525000 |
AOSVVLGOJNFRNH-FUJFQHJFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535398; PubChem:CID135282546
|
Local ready
Direct docking supported
|
|
E3L023544
BDB023544
|
US11236047, Example 144
CC(C)(O)c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cn1)[C@@]2(OCC1(COCC(=O)O)CC1)c1ccc(Cl)cc1
|
C30H29Cl2FN2O6 603.474000 |
GOUTYWNJSCUIGZ-SSEXGKCCSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535400; PubChem:CID135282264
|
Local ready
Direct docking supported
|
|
E3L023545
BDB023545
|
US11236047, Example 180
CCn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(C(N)=O)CC2)c2ccc(Cl)cc2)cn1
|
C32H30Cl2FN5O4 638.527000 |
DCAVGHLCTQJYEH-BDJZEIKTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535401; PubChem:CID135282574
|
Local ready
Direct docking supported
|
|
E3L023546
BDB023546
|
US11236047, Example 295
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CCN(C(=O)c4ncco4)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C32H29Cl2FN4O5 639.511000 |
RQDLJZPOABRDMA-IADGFXSZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535402; PubChem:CID135282892
|
Local ready
Direct docking supported
|
|
E3L023547
BDB023547
|
US11236047, Example 138
CN(C)CC(C)(O)c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cn1)[C@@]2(O[C@H]1CCOC1)c1ccc(Cl)cc1
|
C29H30Cl2FN3O4 574.480000 |
DEHGDPBWKNEFGA-SJAHEGMPSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535403; PubChem:CID135282489
|
Local ready
Direct docking supported
|
|
E3L023548
BDB023548
|
US11236047, Example 156
CC(=O)NCC1(CO[C@]2(c3ccc(Cl)cc3)c3c(F)cc(C(C)(C)O)cc3C(=O)N2Cc2ccc(Cl)cn2)CC1
|
C30H30Cl2FN3O4 586.491000 |
OSEHZDAAYCTXDQ-SSEXGKCCSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535404; PubChem:CID135282082
|
Local ready
Direct docking supported
|
|
E3L023549
BDB023549
|
US11236047, Example 213
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCCO)c2ccc(Cl)cc2)cn1
|
C28H25Cl2FN4O4 571.436000 |
JICFZAOJKDDMCA-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535405; PubChem:CID135282855
|
Local ready
Direct docking supported
|
|
E3L023550
BDB023550
|
US11236047, Example 203
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ncc(Cl)cn2)[C@@]3(OCC2(O)CC2)c2ccc(Cl)cc2)cn1
|
C29H26Cl2FN5O4 598.462000 |
MYMTUGSPJYJBAG-ZBAATNBSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535406; PubChem:CID137497991
|
Local ready
Direct docking supported
|
|
E3L023551
BDB023551
|
US11236047, Example 214
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ncc(Cl)cn2)[C@@]3(OCC2(C(N)=O)CC2)c2ccc(Cl)cc2)cn1
|
C30H27Cl2FN6O4 625.488000 |
YQQJPSAALPSLDT-FUJFQHJFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535408; PubChem:CID135282191
|
Local ready
Direct docking supported
|
|
E3L023552
BDB023552
|
US11236047, Example 311
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CCS(=O)(=O)CC3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C28H27Cl2FN2O5S 593.504000 |
ULHDHSTWWOIQJU-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535409; PubChem:CID137498011
|
Local ready
Direct docking supported
|
|
E3L023553
BDB023553
|
US11236047, Example 216
COc1ccc(CN2C(=O)c3cc(C(C)(O)c4cnn(C)c4)cc(F)c3[C@]2(OCC2(C(N)=O)CC2)c2ccc(Cl)cc2)cn1
|
C32H31ClFN5O5 620.081000 |
QAJDMQMVZQWDGC-BDJZEIKTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535410; PubChem:CID135282578
|
Local ready
Direct docking supported
|
|
E3L023554
BDB023554
|
US11236047, Example 182
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)c3cnn(C4CN(C(C)=O)C4)c3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C31H28Cl2FN5O4 624.500000 |
LHIMDIZJOXHQDM-NLIBRCFJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535411; PubChem:CID135282528
|
Local ready
Direct docking supported
|
|
E3L023555
BDB023555
|
US11236047, Example 140
CCOCC(C)(O)c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cn1)[C@@]2(O[C@H]1CCOC1)c1ccc(Cl)cc1
|
C29H29Cl2FN2O5 575.464000 |
LWOJSHCDLMMOQI-SJAHEGMPSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535412; PubChem:CID135282474
|
Local ready
Direct docking supported
|
|
E3L023556
BDB023556
|
US11236047, Example 142
COCC(C)(O)c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cn1)[C@@]2(O[C@H]1CCOC1)c1ccc(Cl)cc1
|
C28H27Cl2FN2O5 561.437000 |
JTWNLIFKVVQASM-ITLXXOFFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535414; PubChem:CID163407647
|
Local ready
Direct docking supported
|
|
E3L023557
BDB023557
|
US11236047, Example 276
CC(O)(CN1CCCC1)c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(OCC1(C#N)CC1)c1ccc(Cl)cc1
|
C33H31ClFN5O3 600.094000 |
NAJXOWIJGLQLBB-NFCCVXSLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535416; PubChem:CID135282580
|
Local ready
Direct docking supported
|
|
E3L023558
BDB023558
|
US11236047, Example 278
CN1CCN(CC(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(C#N)cn2)[C@@]3(OCC2(C#N)CC2)c2ccc(Cl)cc2)CC1
|
C34H34ClFN6O3 629.136000 |
OFUBYOJVTHCLBN-SZFCLFMZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535418; PubChem:CID135283159
|
Local ready
Direct docking supported
|
|
E3L023559
BDB023559
|
US11236047, Example 195
Cn1cnc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(O)CC2)c2ccc(Cl)cc2)c1
|
C30H27Cl2FN4O4 597.474000 |
FMSSWQMNRMVPPP-FUJFQHJFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535420; PubChem:CID135282939
|
Local ready
Direct docking supported
|
|
E3L023560
BDB023560
|
US11236047, Example 218
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(C#N)cn2)[C@@]3(O[C@H]2CCOC2)c2ccc(Cl)cc2)cn1
|
C31H27ClFN5O4 588.039000 |
IMGHGKVWJOGDFL-OERQIQHUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535421; PubChem:CID135282568
|
Local ready
Direct docking supported
|