| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L023561
BDB023561
|
US11236047, Example 219
COc1ccc(CN2C(=O)c3cc(C(C)(O)c4cnn(C)c4)cc(F)c3[C@]2(OCC2(CO)CC2)c2ccc(Cl)cc2)cn1
|
C32H32ClFN4O5 607.082000 |
SRKAMEZCGUXPSS-BDJZEIKTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535422; PubChem:CID137497980
|
Local ready
Direct docking supported
|
|
E3L023562
BDB023562
|
US11236047, Example 221
C[C@@H](O)CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)c3cnn(C)c3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C29H27Cl2FN4O4 585.463000 |
MNQQXUGKGLDIBL-YQNXAQHZSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535425; PubChem:CID135282239
|
Local ready
Direct docking supported
|
|
E3L023563
BDB023563
|
US11236047, Example 223
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(O[C@H]2CCOC2)c2ccc(Cl)cc2)cn1
|
C30H27Cl2FN4O4 597.474000 |
YSIGKCLZFXUHTB-DHSZNAABSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535426; PubChem:CID135282418
|
Local ready
Direct docking supported
|
|
E3L023564
BDB023564
|
US11236047, Example 224
COc1ccc(CN2C(=O)c3cc(C(C)(O)c4cnn(C)c4)cc(F)c3[C@]2(OCC2(CO)CC2)c2ccc(Cl)cc2)nc1
|
C32H32ClFN4O5 607.082000 |
FCXTWHDUAWMEGT-BDJZEIKTSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535427; PubChem:CID137498003
|
Local ready
Direct docking supported
|
|
E3L023565
BDB023565
|
US11236047, Example 227
Cc1ccc(CN2C(=O)c3cc(C(C)(O)c4cnn(C)c4)cc(F)c3[C@]2(OCC2(O)CC2)c2ccc(Cl)cc2)nc1
|
C31H30ClFN4O4 577.056000 |
DKOKUKMQYMDUPS-ZGVDRVBQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535430; PubChem:CID135282402
|
Local ready
Direct docking supported
|
|
E3L023566
BDB023566
|
US11236047, Example 174
C=C[C@@H](c1ccc(Cl)cn1)N1C(=O)c2cc(C(C)(C)O)cc(F)c2[C@]1(OCC1(O)CC1)c1ccc(Cl)cc1
|
C29H27Cl2FN2O4 557.449000 |
SJKVIISRJBQDPQ-PWUYWRBVSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535431; PubChem:CID135282301
|
Local ready
Direct docking supported
|
|
E3L023567
BDB023567
|
US11236047, Example 183
CCn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(O)CC2)c2ccc(Cl)cc2)cn1
|
C31H29Cl2FN4O4 611.501000 |
QYPLRLGVDBPTMJ-ZGVDRVBQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535432; PubChem:CID135282376
|
Local ready
Direct docking supported
|
|
E3L023568
BDB023568
|
US11236047, Example 373
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)c3cnn(C)c3)cc2C(=O)N1Cc1ncc(Cl)cc1S(C)(=O)=O
|
C28H25Cl2FN4O5S 619.502000 |
IXMPETAWBZRMPY-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535434; PubChem:CID135282963
|
Local ready
Direct docking supported
|
|
E3L023569
BDB023569
|
US11236047, Example 297
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CCN(C(C)=O)CC3)cc2C(=O)N1Cc1ccc(C#N)cn1
|
C31H30ClFN4O4 577.056000 |
UTHIKBCDDXKGAA-NLIBRCFJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535435; PubChem:CID135282693
|
Local ready
Direct docking supported
|
|
E3L023570
BDB023570
|
US11236047, Example 230
COc1ccc(CN2C(=O)c3cc(C(C)(O)c4cnn(C)c4)cc(F)c3[C@]2(OCC2(O)CC2)c2ccc(Cl)cc2)cn1
|
C31H30ClFN4O5 593.055000 |
YHCHSJVYIURCJK-ZGVDRVBQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535436; PubChem:CID137497974
|
Local ready
Direct docking supported
|
|
E3L023571
BDB023571
|
US11236047, Example 231
Cn1cc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(F)cn2)[C@@]3(OCC2(O)CC2)c2ccc(Cl)cc2)cn1
|
C30H27ClF2N4O4 581.019000 |
CUPHKJSAHLYMSR-FUJFQHJFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535438; PubChem:CID137498010
|
Local ready
Direct docking supported
|
|
E3L023572
BDB023572
|
US11236047, Example 186
Cc1nnc(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCC2(O)CC2)c2ccc(Cl)cc2)o1
|
C29H25Cl2FN4O5 599.446000 |
YLSBIZWHGKMZFC-ZBAATNBSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535439; PubChem:CID135282684
|
Local ready
Direct docking supported
|
|
E3L023573
BDB023573
|
US11236047, Example 313
CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cn1)[C@@]2(OCCO)c1ccc(Cl)cc1)C1CCS(=O)(=O)CC1
|
C29H29Cl2FN2O6S 623.530000 |
LNHWDLFOWCRHJS-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535440; PubChem:CID137497990
|
Local ready
Direct docking supported
|
|
E3L023574
BDB023574
|
US11236047, Example 155
CNC(=O)CNCC1(CO[C@]2(c3ccc(Cl)cc3)c3c(F)cc(C(C)(C)O)cc3C(=O)N2Cc2ccc(Cl)cn2)CC1
|
C31H33Cl2FN4O4 615.533000 |
QYDCIWZUSXZNGK-WJOKGBTCSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535441; PubChem:CID135282779
|
Local ready
Direct docking supported
|
|
E3L023575
BDB023575
|
US11236047, Example 385
CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ncc(Cl)cn1)[C@@]2(OCC1(O)CC1)c1ccc(Cl)cc1)C1(F)CCOCC1
|
C30H29Cl2F2N3O5 620.480000 |
NKWFYVHKVVJQBQ-DINWUYGQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535443; PubChem:CID137497986
|
Local ready
Direct docking supported
|
|
E3L023576
BDB023576
|
US11236047, Example 421
CC(=O)N1CCC(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(Cl)cn2)[C@@]3(OCCO)c2ccc(Cl)cc2)CC1
|
C31H32Cl2FN3O5 616.517000 |
CXOYTFMILJYYKW-NLIBRCFJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535445; PubChem:CID135282639
|
Local ready
Direct docking supported
|
|
E3L023577
BDB023577
|
US11236047, Example 357
Cn1cc(C(O)c2cc(F)c3c(c2)C(=O)N(Cc2ccc(C#N)cn2)[C@@]3(O[C@H]2CCOC2)c2ccc(Cl)cc2)cn1
|
C30H25ClFN5O4 574.012000 |
RRUBGLIKOBFXDA-FDTSKNAKSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535446; PubChem:CID135283067
|
Local ready
Direct docking supported
|
|
E3L023578
BDB023578
|
US11236047, Example 390
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CN(C(C)=O)C3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C28H26Cl2FN3O4 558.437000 |
NGYNMONWMIFMBU-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535448; PubChem:CID135282612
|
Local ready
Direct docking supported
|
|
E3L023579
BDB023579
|
US11236047, Example 391
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CN(C(=O)CO)C3)cc2C(=O)N1Cc1ccc(Cl)cn1
|
C28H26Cl2FN3O5 574.436000 |
GIKVEWGVNKXMRA-PLYLYKGUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535449; PubChem:CID135282679
|
Local ready
Direct docking supported
|
|
E3L023580
BDB023580
|
US11236047, Example 405
CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(OCCO)c1ccc(Cl)cc1)C1CCC1
|
C29H27ClFN3O4 536.003000 |
ZDFDJHLMOSFIGS-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535450; PubChem:CID135282605
|
Local ready
Direct docking supported
|