| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L023601
BDB023601
|
US11236047, Example 415
CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1)C1CC1
|
C31H29ClFN3O4 562.041000 |
KFTDOSOUWLTHRI-ZGVDRVBQSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535734; PubChem:CID135282517
|
Local ready
Direct docking supported
|
|
E3L023602
BDB023602
|
US11236047, Example 393
CO[C@]1(c2ccc(Cl)cc2)c2c(F)cc(C(C)(O)C3CN(C(=O)N(C)C)C3)cc2C(=O)N1Cc1ccc(C#N)cn1
|
C30H29ClFN5O4 578.044000 |
YXJHOYZUTJDSKB-BDCODIICSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535735; PubChem:CID135282936
|
Local ready
Direct docking supported
|
|
E3L023603
BDB023603
|
US11236092, Example 16
N#CN1CCC2(Cc3cc(-c4ccccc4OCc4ccccc4)ccc3NC2=O)C1
|
C26H23N3O2 409.489000 |
XGZOUXDQPIRNPR-UHFFFAOYSA-N | Q6GQQ9 | OTU domain-containing protein 7B |
BindingDB, PubChem
BindingDB:BDBM535736; PubChem:CID137378563
|
Local ready
Direct docking supported
|
|
E3L023604
BDB023604
|
BDBM535737
C=CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(O[C@H]1C[C@@H](O)C1)c1ccc(Cl)cc1)c1cnn(C)c1
|
C32H27ClFN5O4 600.050000 |
CBSMDIHLXRBTIK-UGDYSZKESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM535737
|
Local ready
Direct docking supported
|
|
E3L023605
BDB023605
|
US11236092, Example 18
N#CN1CCC2(Cc3cc(-c4ccccc4OCc4ccccc4Cl)ccc3NC2=O)C1
|
C26H22ClN3O2 443.934000 |
TVACQTCCXVRREE-UHFFFAOYSA-N | Q6GQQ9 | OTU domain-containing protein 7B |
BindingDB, PubChem
BindingDB:BDBM535738; PubChem:CID163407655
|
Local ready
Direct docking supported
|
|
E3L023606
BDB023606
|
BDBM535739
CC(=O)N1CCC(C(C)(O)c2cc(F)c3c(c2)C(=O)N(Cc2ncc(Cl)cn2)[C@@]3(O[C@H]2C[C@@H](O)C2)c2ccc(Cl)cc2)CC1
|
C32H33Cl2FN4O5 643.543000 |
NQWJDULBVXLQNH-GYUPVUOFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM535739
|
Local ready
Direct docking supported
|
|
E3L023607
BDB023607
|
US11236047, Example 400
O=C1c2cc(C(O)C3CCS(=O)(=O)CC3)cc(F)c2[C@](OCC2(O)CC2)(c2ccc(Cl)cc2)N1Cc1ncc(Cl)cn1
|
C29H28Cl2FN3O6S 636.529000 |
ONJSKBXTOJKOHB-BNGNXUGRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535740; PubChem:CID137497957
|
Local ready
Direct docking supported
|
|
E3L023608
BDB023608
|
US11236047, Example 364
CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(OCCO)c1ccc(Cl)cc1)c1cn(C)cn1
|
C30H27ClFN5O4 576.028000 |
NDQMLIDFCBBJEJ-BDCODIICSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535741; PubChem:CID135282564
|
Local ready
Direct docking supported
|
|
E3L023609
BDB023609
|
US11236092, Example 105
Cc1n[nH]c2cc(-c3ccc4c(c3)CC3(CCN(C#N)C3)C(=O)N4)ccc12
|
C21H19N5O 357.417000 |
IPHNXWSLDIBDAI-UHFFFAOYSA-N | Q6GQQ9 | OTU domain-containing protein 7B |
BindingDB, PubChem
BindingDB:BDBM535742; PubChem:CID137378644
|
Local ready
Direct docking supported
|
|
E3L023610
BDB023610
|
US11236047, Example 333
CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(OCCO)c1ccc(Cl)cc1)c1cscn1
|
C29H24ClFN4O4S 579.053000 |
XIIWYJNBDQFHIK-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535743; PubChem:CID135282999
|
Local ready
Direct docking supported
|
|
E3L023611
BDB023611
|
US11236047, Example 365
CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(O[C@H]1CCOC1)c1ccc(Cl)cc1)c1cn(C)cn1
|
C32H29ClFN5O4 602.066000 |
XHCNIWPQGUYHCF-LOKXLOOWSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535744; PubChem:CID137498006
|
Local ready
Direct docking supported
|
|
E3L023612
BDB023612
|
BDBM535746
CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ncc(Cl)cn1)[C@@]2(OCC1(CO)CC1)c1ccc(Cl)cc1)[C@H]1CC[C@H](O)CC1
|
C32H34Cl2FN3O5 630.544000 |
FFCUBEPVLPUEKV-TXICZZBISA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM535746
|
Local ready
Direct docking supported
|
|
E3L023613
BDB023613
|
US11236047, Example 367
CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)nc1)[C@@]2(OCCO)c1ccc(Cl)cc1)c1cn(C)cn1
|
C29H27Cl2FN4O4 585.463000 |
WRBVILCYNJXAHL-YPJJGMIRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535747; PubChem:CID135282741
|
Local ready
Direct docking supported
|
|
E3L023614
BDB023614
|
US11236047, Example 374
CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(O[C@H]1CCOC1)c1ccc(Cl)cc1)c1ccn(C)c(=O)c1
|
C34H30ClFN4O5 629.088000 |
BBYFUSWKYJIKDG-FNHRJEOVSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535748; PubChem:CID135282488
|
Local ready
Direct docking supported
|
|
E3L023615
BDB023615
|
US11236047, Example 388
CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(O[C@H]1CCOC1)c1ccc(Cl)cc1)C1(F)CCOCC1
|
C32H30ClF2N3O5 610.057000 |
GGKZSFCTBQWUHO-HZGBORAXSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535749; PubChem:CID135282626
|
Local ready
Direct docking supported
|
|
E3L023616
BDB023616
|
US11236092, Example 130
CN(C)C(=O)c1cccc(-c2ccc3c(c2)CC2(CCN(C#N)C2)C(=O)N3)c1
|
C22H22N4O2 374.444000 |
ARMYHELMKIDFPE-UHFFFAOYSA-N | Q6GQQ9 | OTU domain-containing protein 7B |
BindingDB, PubChem
BindingDB:BDBM535750; PubChem:CID137378637
|
Local ready
Direct docking supported
|
|
E3L023617
BDB023617
|
US11236047, Example 369
CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ncc(C#N)cn1)[C@@]2(O[C@H]1CCOC1)c1ccc(Cl)cc1)c1cn(C)cn1
|
C31H28ClFN6O4 603.054000 |
XUQLKCXDANADHI-GMMQIRHLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535751; PubChem:CID135282956
|
Local ready
Direct docking supported
|
|
E3L023618
BDB023618
|
BDBM535752
CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(O[C@H]1C[C@@H](O)C1)c1ccc(Cl)cc1)c1cnn(C)c1
|
C32H29ClFN5O4 602.066000 |
RFTMWICFZAQJMI-UGDYSZKESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM535752
|
Local ready
Direct docking supported
|
|
E3L023619
BDB023619
|
US11236047, Example 433
Cn1cnc(C(O)(c2cc(F)c3c(c2)C(=O)N(Cc2ccc(C#N)cn2)[C@@]3(O[C@H]2CCOC2)c2ccc(Cl)cc2)C2CC2)c1
|
C33H29ClFN5O4 614.077000 |
DQSUJJZOQXTIMY-UBORAUAPSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM535753; PubChem:CID135282888
|
Local ready
Direct docking supported
|
|
E3L023620
BDB023620
|
US11236092, Example 131
Cc1cc(-c2ccc3c(c2)CC2(CCN(C#N)C2)C(=O)N3)ccn1
|
C19H18N4O 318.380000 |
XRVQQNQHGBMAJC-UHFFFAOYSA-N | Q6GQQ9 | OTU domain-containing protein 7B |
BindingDB, PubChem
BindingDB:BDBM535754; PubChem:CID137378571
|
Local ready
Direct docking supported
|