| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L017961
BDB017961
|
US10544132, Example 125
CC[C@](C)(O)c1cc(F)c2c(c1)C(=O)N([C@@H](CC(=O)O)c1ccc(Cl)cc1)[C@@]2(OCC1(F)COC1)c1ccc(Cl)cc1
|
C31H29Cl2F2NO6 620.476000 |
NAMQEWAUDBCILZ-ZITMISKDSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427184; PubChem:CID154733014
|
Local ready
Direct docking supported
|
|
E3L017962
BDB017962
|
US10544132, Example 126
CC[C@@](C)(O)c1cc(F)c2c(c1)C(=O)N([C@@H](CC(=O)O)c1ccc(Cl)cc1)[C@@]2(OCC1(F)COC1)c1ccc(Cl)cc1
|
C31H29Cl2F2NO6 620.476000 |
NAMQEWAUDBCILZ-FPHQXIGGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427185; PubChem:CID154733015
|
Local ready
Direct docking supported
|
|
E3L017963
BDB017963
|
US10544132, Example 127
CC[C@@](O)(c1cc(F)c2c(c1)C(=O)N([C@@H](CC(=O)O)c1ccc(Cl)cc1)[C@@]2(OC)c1ccc(Cl)cc1)c1ccccn1
|
C32H27Cl2FN2O5 609.481000 |
KHSRSNYUTBONQS-OODHRNECSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427186; PubChem:CID154733016
|
Local ready
Direct docking supported
|
|
E3L017964
BDB017964
|
US10544132, Example 128
CC[C@](O)(c1cc(F)c2c(c1)C(=O)N([C@@H](CC(=O)O)c1ccc(Cl)cc1)[C@@]2(OC)c1ccc(Cl)cc1)c1ccccn1
|
C32H27Cl2FN2O5 609.481000 |
KHSRSNYUTBONQS-XBZWSRNISA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427187; PubChem:CID154733017
|
Local ready
Direct docking supported
|
|
E3L017965
BDB017965
|
US10544132, Example 129
CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cc1S(C)(=O)=O)[C@@]2(OC)c1ccc(Cl)cc1)C1(F)CCNCC1
|
C31H32Cl2F2N2O5S 653.575000 |
YMXGZYIWCPLVGI-NLIBRCFJSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427188; PubChem:CID135281595
|
Local ready
Direct docking supported
|
|
E3L017966
BDB017966
|
BDBM427189
CC[C@@](O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cc1)C2(O[C@H]1C[C@@H](O)C1)c1ccc(Cl)cc1)C1CCN(C)CC1
|
C35H37ClFN3O4 618.149000 |
RVEVEKZOUQPWSR-JOEBACTPSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM427189
|
Local ready
Direct docking supported
|
|
E3L017967
BDB017967
|
US10544132, Example 131
CCC(O)(c1cc(F)c2c(c1)C(=O)N([C@@H](CC(=O)O)c1ccc(Cl)cc1)[C@@]2(OC)c1ccc(Cl)cc1)C1(F)CCN(C)CC1
|
C33H34Cl2F2N2O5 647.546000 |
UASWWYBCWGDNKX-ATPTUWPCSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427190; PubChem:CID135281617
|
Local ready
Direct docking supported
|
|
E3L017968
BDB017968
|
US10544132, Example 132
CC[C@@](O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cc1)[C@@]2(OC)c1ccc(Cl)cc1)C1CCN(CC(=O)OC(C)(C)C)CC1
|
C36H41Cl2FN2O5 671.637000 |
RGCRBSVSBVXCDO-MPQUPPDSSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427191; PubChem:CID135281894
|
Local ready
Direct docking supported
|
|
E3L017969
BDB017969
|
US10544132, Example 133
CC[C@](O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cc1)[C@@]2(OC)c1ccc(Cl)cc1)C1CCN(CC(=O)OC(C)(C)C)CC1
|
C36H41Cl2FN2O5 671.637000 |
RGCRBSVSBVXCDO-LQFQNGICSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427192; PubChem:CID135281629
|
Local ready
Direct docking supported
|
|
E3L017970
BDB017970
|
US10544132, Example 134
CC[C@](O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cc1)[C@@]2(OC)c1ccc(Cl)cc1)C1CCN(CC(=O)O)CC1
|
C32H33Cl2FN2O5 615.529000 |
MFPOPVHVIGVWNK-ROJLCIKYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427193; PubChem:CID135281491
|
Local ready
Direct docking supported
|
|
E3L017971
BDB017971
|
US10544132, Example 135
CC[C@@](O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cc1)[C@@]2(OC)c1ccc(Cl)cc1)C1CCN(CC(=O)O)CC1
|
C32H33Cl2FN2O5 615.529000 |
MFPOPVHVIGVWNK-AJQTZOPKSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427194; PubChem:CID135281570
|
Local ready
Direct docking supported
|
|
E3L017972
BDB017972
|
US10544132, Example 136
CC[C@@](O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cc1)[C@@]2(OC)c1ccc(Cl)cc1)C1CCN(CCC(=O)OC)CC1
|
C34H37Cl2FN2O5 643.583000 |
ATEBGPCVCPBSLM-SZAHLOSFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427195; PubChem:CID135281761
|
Local ready
Direct docking supported
|
|
E3L017973
BDB017973
|
US10544132, Example 137
CC[C@@](O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(Cl)cc1)C2(OC)c1ccc(Cl)cc1)C1CCN(CCC(=O)O)CC1
|
C33H35Cl2FN2O5 629.556000 |
ZKUGFHUACFYRES-JEFWXSHNSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM427196; PubChem:CID154733018
|
Local ready
Direct docking supported
|
|
E3L017974
BDB017974
|
Atamparib
C[C@@H](COCCC(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1)Nc1cn[nH]c(=O)c1C(F)(F)F
|
C20H23F6N7O3 523.438000 |
UQZCQKXJAXKZQH-LBPRGKRZSA-N | P09874 | Poly [ADP-ribose] polymerase 1 |
BindingDB, PubChem
BindingDB:BDBM431646; PubChem:CID146047148
|
Local ready
Direct docking supported
|
|
E3L017975
BDB017975
|
US10576064, Example I-1
O=C1NCC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C24H22Cl2FN3O2 474.363000 |
SRPIXZGCAVXKGO-CMCWBKRRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431935; PubChem:CID118639881
|
Local ready
Direct docking supported
|
|
E3L017976
BDB017976
|
US10576064, Example I-3
O=C1NCC[C@H]2[C@@H]1[C@H](c1cccc(Cl)c1)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C24H23Cl2N3O2 456.373000 |
DYCATYMTBZSSMF-SEDAZVQISA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431937; PubChem:CID118641396
|
Local ready
Direct docking supported
|
|
E3L017977
BDB017977
|
US10576064, Example I-5
CCOc1cccc(CN2[C@H]3CCNC(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C29H26Cl2FN3O3 554.449000 |
BJHMTGTXPKRGKQ-APSVEGKFSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431939; PubChem:CID118641398
|
Local ready
Direct docking supported
|
|
E3L017978
BDB017978
|
US10576064, Example I-7
CCOc1cccc(CN2[C@H]3CCNC(=O)[C@H]3[C@H](c3cccc(Cl)c3)[C@]23C(=O)Nc2cc(Cl)ccc23)c1
|
C29H27Cl2N3O3 536.459000 |
CBQPGXSMFYHCRJ-XWDJFTLGSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431940; PubChem:CID118641810
|
Local ready
Direct docking supported
|
|
E3L017979
BDB017979
|
US10576064, Example I-9
CCOc1cccc(CN2[C@H]3CCNC(=O)[C@H]3[C@H](c3cccc(Cl)c3F)[C@]23C(=O)Nc2nc(Cl)ccc23)c1
|
C28H25Cl2FN4O3 555.437000 |
KVWHDOKKXPSVDI-CRQKQFHESA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431941; PubChem:CID118641394
|
Local ready
Direct docking supported
|
|
E3L017980
BDB017980
|
US10576064, Example I-11
O=C1NCC[C@H]2[C@@H]1[C@H](c1cc(Br)cc(Cl)c1F)[C@]1(C(=O)Nc3cc(Cl)ccc31)N2CC1CC1
|
C24H21BrCl2FN3O2 553.259000 |
TYUIYSAYGSXJLP-CMCWBKRRSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM431942; PubChem:CID118639847
|
Local ready
Direct docking supported
|