| Compound ID | Name | Formula / MW | InChIKey | E3 | Target | Source | Docking structure |
|---|---|---|---|---|---|---|---|
|
E3L005321
BDB005321
|
BDBM129813
COc1ncc(-c2nc3c(n2C(C)C)C(c2ccc(Cl)cc2)N(c2cc(C)nn2C)C3=O)c(OC)n1
|
C25H26ClN7O3 507.982000 |
YQDCYUMBOQNRAN-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129813; PubChem:CID71679111
|
Local ready
Direct docking supported
|
|
E3L005322
BDB005322
|
BDBM129814
COc1cnc(CC#N)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cccc(Cl)c1F)C2=O
|
C29H24Cl2FN5O2 564.448000 |
WKQVUFZCWPVAIV-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129814; PubChem:CID86766915
|
Local ready
Direct docking supported
|
|
E3L005323
BDB005323
|
BDBM129815
COc1nc(N(C)C)ncc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1)N(c1ccc(C(N)=O)cc1C)C2=O
|
C29H30ClN7O3 560.058000 |
KDUYBJFMZZLHIB-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129815; PubChem:CID86766916
|
Local ready
Direct docking supported
|
|
E3L005324
BDB005324
|
BDBM129816
COc1ncc(-c2nc3c(n2C(C)C)C(c2ccc(Cl)cc2)N(c2ccc(C(N)=O)cc2C)C3=O)c(OC)n1
|
C28H27ClN6O4 547.015000 |
KGXIGECSLXWHMJ-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129816; PubChem:CID86766917
|
Local ready
Direct docking supported
|
|
E3L005325
BDB005325
|
BDBM129817
COc1c[nH]c(=O)nc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1)N(c1cccc(Cl)c1F)C2=O
|
C25H20Cl2FN5O3 528.371000 |
DFCWPSYEMDMWTP-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129817; PubChem:CID89714786
|
Local ready
Direct docking supported
|
|
E3L005326
BDB005326
|
BDBM129819
COc1ncc(-c2nc3c(n2C(C)C)C(c2ccc(Cl)cc2)N([C@H]2CC[C@H](C(=O)O)CC2)C3=O)c(OC)n1
|
C27H30ClN5O5 540.020000 |
OGQNROWARMVZRY-NEDBQFRUSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM129819
|
Local ready
Direct docking supported
|
|
E3L005327
BDB005327
|
BDBM129820
COc1ncc(-c2nc3c(n2C(C)C)C(c2ccc(Cl)cc2)N([C@H]2CC[C@H](NC(C)=O)CC2)C3=O)c(OC)n1
|
C28H33ClN6O4 553.063000 |
UUVPTAYZKNPPLL-PBVHZTIHSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM129820
|
Local ready
Direct docking supported
|
|
E3L005328
BDB005328
|
BDBM129821
COc1nc(N(C)C)ncc1-c1nc2c(n1C(C)C)C(c1ccc(C#N)cc1)N(c1cc(Cl)cn(C)c1=O)C2=O
|
C28H27ClN8O3 559.030000 |
YNFVSWHRMQTJHZ-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129821; PubChem:CID86766920
|
Local ready
Direct docking supported
|
|
E3L005329
BDB005329
|
Siremadlin
COc1ncc(-c2nc3c(n2C(C)C)[C@H](c2ccc(Cl)cc2)N(c2cc(Cl)cn(C)c2=O)C3=O)c(OC)n1
|
C26H24Cl2N6O4 555.422000 |
AGBSXNCBIWWLHD-FQEVSTJZSA-N | O15151, Q00987 | Protein Mdm4, E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129823; PubChem:CID71678098
|
Local ready
Direct docking supported
|
|
E3L005330
BDB005330
|
Siremadlin (R Enantiomer)
COc1ncc(-c2nc3c(n2C(C)C)[C@@H](c2ccc(Cl)cc2)N(c2cc(Cl)cn(C)c2=O)C3=O)c(OC)n1
|
C26H24Cl2N6O4 555.422000 |
AGBSXNCBIWWLHD-HXUWFJFHSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129824; PubChem:CID71679278
|
Local ready
Direct docking supported
|
|
E3L005331
BDB005331
|
BDBM129825
CNC(=O)[C@H]1CC[C@H](N2C(=O)c3nc(-c4cnc(OC)nc4OC)n(C(C)C)c3C2c2ccc(Cl)cc2)CC1
|
C28H33ClN6O4 553.063000 |
DDIQYBKLJFOZCN-NRCGHCQOSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB
BindingDB:BDBM129825
|
Local ready
Direct docking supported
|
|
E3L005332
BDB005332
|
BDBM129826
COc1cn(C)c(=O)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1)N(c1ccc(F)c(Cl)c1)C2=O
|
C27H23Cl2FN4O3 541.410000 |
FBIRRCPVUJUTLH-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129826; PubChem:CID86766921
|
Local ready
Direct docking supported
|
|
E3L005333
BDB005333
|
BDBM129827
COc1cnc(CC#N)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1C)N(c1cc(Cl)ccc1C)C2=O
|
C30H27Cl2N5O2 560.485000 |
NNDLFSFQMZALLB-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129827; PubChem:CID86766922
|
Local ready
Direct docking supported
|
|
E3L005334
BDB005334
|
BDBM129828
COc1cnc(CC#N)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1)N(c1cc(Cl)ccc1C)C2=O
|
C29H25Cl2N5O2 546.458000 |
DMPHYLLCQIYWRV-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129828; PubChem:CID86766923
|
Local ready
Direct docking supported
|
|
E3L005335
BDB005335
|
BDBM129829
COc1cnc(CC#N)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1)N(c1cc(Cl)cn(C)c1=O)C2=O
|
C28H24Cl2N6O3 563.445000 |
AISRPLVGFXVXMM-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129829; PubChem:CID86766924
|
Local ready
Direct docking supported
|
|
E3L005336
BDB005336
|
BDBM129830
COc1cn(C)c(=O)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1)N(c1cccc(Cl)c1F)C2=O
|
C27H23Cl2FN4O3 541.410000 |
JGHQGBNEVDBWHA-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129830; PubChem:CID86766925
|
Local ready
Direct docking supported
|
|
E3L005337
BDB005337
|
BDBM129831
COc1cn(C)c(=O)cc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1)N(c1cc(Cl)ccc1C)C2=O
|
C28H26Cl2N4O3 537.447000 |
YKSXNRAQUQNKTG-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129831; PubChem:CID86766926
|
Local ready
Direct docking supported
|
|
E3L005338
BDB005338
|
BDBM129832
COC[C@@H](C)n1c(-c2cnc(OC)nc2OC)nc2c1C(c1ccc(Cl)cc1)N(c1cc(Cl)ccc1C)C2=O
|
C28H27Cl2N5O4 568.461000 |
TWAINRRINSLNFG-ADRQNKRLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129832; PubChem:CID86766927
|
Local ready
Direct docking supported
|
|
E3L005339
BDB005339
|
BDBM129833
COc1cnc(N(C)CCO)nc1-c1nc2c(n1C(C)C)C(c1ccc(Cl)cc1)N(c1ccc(F)c(Cl)c1)C2=O
|
C28H27Cl2FN6O3 585.467000 |
DJZRWGHYIQRXJX-UHFFFAOYSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129833; PubChem:CID86766928
|
Local ready
Direct docking supported
|
|
E3L005340
BDB005340
|
BDBM129834
COc1nc(N(C)C)ncc1-c1nc2c(n1[C@H](C)CO)C(c1ccc(Cl)cc1)N(c1cc(Cl)ccc1C)C2=O
|
C28H28Cl2N6O3 567.477000 |
CUYNDKOCJHCFNP-ADRQNKRLSA-N | Q00987 | E3 ubiquitin-protein ligase Mdm2 |
BindingDB, PubChem
BindingDB:BDBM129834; PubChem:CID71679280
|
Local ready
Direct docking supported
|